Limits...
A case of Hodgkin's lymphoma associated with sensory neuropathy.

Oh BC, Lim YM, Kwon YM, Khang SK, Kim KK - J. Korean Med. Sci. (2004)

Bottom Line: We report a patient with lymphoma whose chief complaint was a sensory loss in the hands and feet.Electrophysiologic studies and sural nerve biopsy showed sensory polyneuropathies.We hypothesize that this neuropathy is associated with lymphoma-related ganglionopathy, and among the possible causes, we suspect that a systemic cause such as a paraneoplastic syndrome is the most likely pathogenic etiology.

View Article: PubMed Central - PubMed

Affiliation: Department of Neurology, University of Ulsan College of Medicine, Asan Medical Center, 388-1 Pungnap-dong, Songpa-gu, Seoul 138-736, Korea.

ABSTRACT
Peripheral neuropathies occur in lymphoma patients. Causes of neuropathy include chemotherapy, opportunistic infections, and the lymphoma itself. We report a patient with lymphoma whose chief complaint was a sensory loss in the hands and feet. Electrophysiologic studies and sural nerve biopsy showed sensory polyneuropathies. We hypothesize that this neuropathy is associated with lymphoma-related ganglionopathy, and among the possible causes, we suspect that a systemic cause such as a paraneoplastic syndrome is the most likely pathogenic etiology. However, further follow-up will be necessary to see whether sensory symptoms change with lymphoma treatment.

Show MeSH

Related in: MedlinePlus

Lymph node biopsy (H&E stain, ×20). Microscopically, the mass exhibits diffuse effacement of lymph node architecture and granulomas. Inset is the enlarged picture (×200) of the area indicated by arrow.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC2822249&req=5

Figure 1: Lymph node biopsy (H&E stain, ×20). Microscopically, the mass exhibits diffuse effacement of lymph node architecture and granulomas. Inset is the enlarged picture (×200) of the area indicated by arrow.

Mentions: After the admission, biopsies of the left inguinal mass and the left sural nerve were performed. Grossly, the inguinal mass measured 8.5 cm in its greatest dimension, and it was well-encapsulated, grayish tan, and solid with fresh fish appearance. Microscopically, the mass exhibited diffuse effacement of lymph node architecture and multiple granulomas (Fig. 1). Many large atypical mononuclear or binuclear cells, including Reed-Sternberg cells, were scattered among many mature lymphocytes rare eosinophils, and plasma cells (Fig. 2). By immunohistochemical staining, the large atypical cells were tested positive for CD15 and CD30, and the diagnosis of Hodgkin's disease lymphocyte rich (classical) type, was made from the inguinal mass (5).


A case of Hodgkin's lymphoma associated with sensory neuropathy.

Oh BC, Lim YM, Kwon YM, Khang SK, Kim KK - J. Korean Med. Sci. (2004)

Lymph node biopsy (H&E stain, ×20). Microscopically, the mass exhibits diffuse effacement of lymph node architecture and granulomas. Inset is the enlarged picture (×200) of the area indicated by arrow.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC2822249&req=5

Figure 1: Lymph node biopsy (H&E stain, ×20). Microscopically, the mass exhibits diffuse effacement of lymph node architecture and granulomas. Inset is the enlarged picture (×200) of the area indicated by arrow.
Mentions: After the admission, biopsies of the left inguinal mass and the left sural nerve were performed. Grossly, the inguinal mass measured 8.5 cm in its greatest dimension, and it was well-encapsulated, grayish tan, and solid with fresh fish appearance. Microscopically, the mass exhibited diffuse effacement of lymph node architecture and multiple granulomas (Fig. 1). Many large atypical mononuclear or binuclear cells, including Reed-Sternberg cells, were scattered among many mature lymphocytes rare eosinophils, and plasma cells (Fig. 2). By immunohistochemical staining, the large atypical cells were tested positive for CD15 and CD30, and the diagnosis of Hodgkin's disease lymphocyte rich (classical) type, was made from the inguinal mass (5).

Bottom Line: We report a patient with lymphoma whose chief complaint was a sensory loss in the hands and feet.Electrophysiologic studies and sural nerve biopsy showed sensory polyneuropathies.We hypothesize that this neuropathy is associated with lymphoma-related ganglionopathy, and among the possible causes, we suspect that a systemic cause such as a paraneoplastic syndrome is the most likely pathogenic etiology.

View Article: PubMed Central - PubMed

Affiliation: Department of Neurology, University of Ulsan College of Medicine, Asan Medical Center, 388-1 Pungnap-dong, Songpa-gu, Seoul 138-736, Korea.

ABSTRACT
Peripheral neuropathies occur in lymphoma patients. Causes of neuropathy include chemotherapy, opportunistic infections, and the lymphoma itself. We report a patient with lymphoma whose chief complaint was a sensory loss in the hands and feet. Electrophysiologic studies and sural nerve biopsy showed sensory polyneuropathies. We hypothesize that this neuropathy is associated with lymphoma-related ganglionopathy, and among the possible causes, we suspect that a systemic cause such as a paraneoplastic syndrome is the most likely pathogenic etiology. However, further follow-up will be necessary to see whether sensory symptoms change with lymphoma treatment.

Show MeSH
Related in: MedlinePlus