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The relationship between disc degeneration and morphologic changes in the intervertebral foramen of the cervical spine: a cadaveric MRI and CT study.

Sohn HM, You JW, Lee JY - J. Korean Med. Sci. (2004)

Bottom Line: The segmental angles were decreased more in advanced degenerated discs.There was a correlation between nerve root compression and decreased foraminal width and area (p<0.005).This information and critical dimensions of the intervertebral foramen for nerve root compression should help in the diagnosis of foraminal stenosis of the cervical spine in patients presenting with cervical spondylosis and radiculopathy.

View Article: PubMed Central - PubMed

Affiliation: Department of Orthopaedic Surgery, Chosun University Hospital, Gwangju, Korea. jwyou@chosun.ac.kr

ABSTRACT
A cadaveric study was performed to investigate the relationship between disc degeneration and morphological changes in the intervertebral foramen of cervical spine, including the effect on the nerve root. Seven fresh frozen human cadavers were dissected from C1 to T1, preserving the ligaments, capsules, intervertebral disc and the neural structures. The specimens were scanned with MRI and then scanned through CT scan in the upright position. Direct mid-sagittal and 45 degree oblique images were obtained to measure the dimension of the intervertebral disc height, foraminal height, width, area and segmental angles. Disc degeneration was inversely correlated with disc height. There was a significant correlation between disc degeneration and foraminal width (p<0.005) and foraminal area (p< 0.05), but not with foraminal height. Disc height was correlated with foraminal width but not with height. The segmental angles were decreased more in advanced degenerated discs. There was a correlation between nerve root compression and decreased foraminal width and area (p<0.005). This information and critical dimensions of the intervertebral foramen for nerve root compression should help in the diagnosis of foraminal stenosis of the cervical spine in patients presenting with cervical spondylosis and radiculopathy.

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(A) T1-weighted (500/16), 45 degree oblique projections of magnetic resonance imaging of the cervical spine, 1.0 mm slice thickness. (B) MRI shows decreased width and area at C5-6 intervertebral foramen (arrow), but relative conservation of foraminal height.
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Figure 1: (A) T1-weighted (500/16), 45 degree oblique projections of magnetic resonance imaging of the cervical spine, 1.0 mm slice thickness. (B) MRI shows decreased width and area at C5-6 intervertebral foramen (arrow), but relative conservation of foraminal height.

Mentions: Total 35 motion segments from C2 to C7 were studied. Using a 1.5 T Signa scanner (GE Medical Systems, Milwaukee, WI, U.S.A.), sagittal images on T1 (TR: 500 ms, TE: 40 ms, FOV: 16×16 cm) and T2 (TR: 4,000 ms, TE: 90 ms, FOV: 16×16 cm) image condition were acquired to allow for measurement of disc degeneration. Criteria by Frymoyer and Gordon (8) were used in this study to clarify the degeneration of disc. The specimens were scanned in an erect position to make a lordotic curve of cervical spine, even though the head was absent. The medial edge of the foramen was identified and several images were taken progressing laterally through the foramen in 45 degree oblique projections (TR: 500 ms, TE: 16 ms, FOV: 16×16 cm, 1.0 mm slice thickness) (Fig. 1). The image included the medial margin of each pedicle, the isthmus of the foramen, and the lateral edge of the foramen and vertebral artery.


The relationship between disc degeneration and morphologic changes in the intervertebral foramen of the cervical spine: a cadaveric MRI and CT study.

Sohn HM, You JW, Lee JY - J. Korean Med. Sci. (2004)

(A) T1-weighted (500/16), 45 degree oblique projections of magnetic resonance imaging of the cervical spine, 1.0 mm slice thickness. (B) MRI shows decreased width and area at C5-6 intervertebral foramen (arrow), but relative conservation of foraminal height.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC2822244&req=5

Figure 1: (A) T1-weighted (500/16), 45 degree oblique projections of magnetic resonance imaging of the cervical spine, 1.0 mm slice thickness. (B) MRI shows decreased width and area at C5-6 intervertebral foramen (arrow), but relative conservation of foraminal height.
Mentions: Total 35 motion segments from C2 to C7 were studied. Using a 1.5 T Signa scanner (GE Medical Systems, Milwaukee, WI, U.S.A.), sagittal images on T1 (TR: 500 ms, TE: 40 ms, FOV: 16×16 cm) and T2 (TR: 4,000 ms, TE: 90 ms, FOV: 16×16 cm) image condition were acquired to allow for measurement of disc degeneration. Criteria by Frymoyer and Gordon (8) were used in this study to clarify the degeneration of disc. The specimens were scanned in an erect position to make a lordotic curve of cervical spine, even though the head was absent. The medial edge of the foramen was identified and several images were taken progressing laterally through the foramen in 45 degree oblique projections (TR: 500 ms, TE: 16 ms, FOV: 16×16 cm, 1.0 mm slice thickness) (Fig. 1). The image included the medial margin of each pedicle, the isthmus of the foramen, and the lateral edge of the foramen and vertebral artery.

Bottom Line: The segmental angles were decreased more in advanced degenerated discs.There was a correlation between nerve root compression and decreased foraminal width and area (p<0.005).This information and critical dimensions of the intervertebral foramen for nerve root compression should help in the diagnosis of foraminal stenosis of the cervical spine in patients presenting with cervical spondylosis and radiculopathy.

View Article: PubMed Central - PubMed

Affiliation: Department of Orthopaedic Surgery, Chosun University Hospital, Gwangju, Korea. jwyou@chosun.ac.kr

ABSTRACT
A cadaveric study was performed to investigate the relationship between disc degeneration and morphological changes in the intervertebral foramen of cervical spine, including the effect on the nerve root. Seven fresh frozen human cadavers were dissected from C1 to T1, preserving the ligaments, capsules, intervertebral disc and the neural structures. The specimens were scanned with MRI and then scanned through CT scan in the upright position. Direct mid-sagittal and 45 degree oblique images were obtained to measure the dimension of the intervertebral disc height, foraminal height, width, area and segmental angles. Disc degeneration was inversely correlated with disc height. There was a significant correlation between disc degeneration and foraminal width (p<0.005) and foraminal area (p< 0.05), but not with foraminal height. Disc height was correlated with foraminal width but not with height. The segmental angles were decreased more in advanced degenerated discs. There was a correlation between nerve root compression and decreased foraminal width and area (p<0.005). This information and critical dimensions of the intervertebral foramen for nerve root compression should help in the diagnosis of foraminal stenosis of the cervical spine in patients presenting with cervical spondylosis and radiculopathy.

Show MeSH
Related in: MedlinePlus