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Influence of Salvia miltiorrhizae on the mesenteric lymph node of rats with severe acute pancreatitis or obstructive jaundice.

Xiping Z, Jie Z, Shuyun Y, Qili W, Guanghua F, Yan P - Mediators Inflamm. (2010)

Bottom Line: At various time points after operation, the pathological changes in mesenteric lymph nodes of rats in each group were observed, respectively.The pathological severity scores in lymph nodes of SAP rats in treated group were significantly lower than those in model control group (P < .05) while the pathological changes in lymph nodes of OJ rats in treated group also showed varying degrees of mitigation.Salvia miltiorrhizae can exert protective effects on the lymph nodes of SAP or OJ rats via a mechanism that is associated with reducing the contents of inflammatory mediators in blood.

View Article: PubMed Central - PubMed

Affiliation: Department of General Surgery, Hangzhou First People's Hospital, Zhejiang Province, Hangzhou 310006, China.

ABSTRACT

Objective: To observe the effect of salvia miltiorrhizae injection on inflammatory mediator levels and mesenteric lymph nodes in severe acute pancreatitis (SAP) and obstructive jaundice (OJ) rats and explore the protective mechanism of salvia miltiorrhizae on the lymph nodes of these rats.

Methods: A total of 288 rats were used in SAP-associated and OJ-associated experiments. The rats were randomly divided into sham-operated group, model control group, and treated group. At various time points after operation, the pathological changes in mesenteric lymph nodes of rats in each group were observed, respectively.

Results: The pathological severity scores in lymph nodes of SAP rats in treated group were significantly lower than those in model control group (P < .05) while the pathological changes in lymph nodes of OJ rats in treated group also showed varying degrees of mitigation.

Conclusion: Salvia miltiorrhizae can exert protective effects on the lymph nodes of SAP or OJ rats via a mechanism that is associated with reducing the contents of inflammatory mediators in blood.

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Related in: MedlinePlus

Treated group: 28 days in OJ rat expansion of lymph sinuses, hyperplasia of sinus cells, and infiltration of inflammatory cells, HE × 200.
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fig5: Treated group: 28 days in OJ rat expansion of lymph sinuses, hyperplasia of sinus cells, and infiltration of inflammatory cells, HE × 200.

Mentions: Grossly, the pathological changes showed no marked difference on 7 days after operation when compared with those in model control group; on 14 days after operation, lymph nodes became yellow but showed no marked difference compared with those in model control group; on 21 and 28 days after operation, the pathological changes showed no marked difference compared with those in model control group. Under light microscopy, no marked difference in pathological changes was observed among each time points after operation; at all time points after operation, the boundary of the follicular germinal centers in lymph nodes was clear; the enlargement of the follicular germinal centers and the hyperplasia of sinus cells were seen in the majority of rats; and few rats showed no obvious pathological changes in lymph nodes; see Figure 5.


Influence of Salvia miltiorrhizae on the mesenteric lymph node of rats with severe acute pancreatitis or obstructive jaundice.

Xiping Z, Jie Z, Shuyun Y, Qili W, Guanghua F, Yan P - Mediators Inflamm. (2010)

Treated group: 28 days in OJ rat expansion of lymph sinuses, hyperplasia of sinus cells, and infiltration of inflammatory cells, HE × 200.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC2822241&req=5

fig5: Treated group: 28 days in OJ rat expansion of lymph sinuses, hyperplasia of sinus cells, and infiltration of inflammatory cells, HE × 200.
Mentions: Grossly, the pathological changes showed no marked difference on 7 days after operation when compared with those in model control group; on 14 days after operation, lymph nodes became yellow but showed no marked difference compared with those in model control group; on 21 and 28 days after operation, the pathological changes showed no marked difference compared with those in model control group. Under light microscopy, no marked difference in pathological changes was observed among each time points after operation; at all time points after operation, the boundary of the follicular germinal centers in lymph nodes was clear; the enlargement of the follicular germinal centers and the hyperplasia of sinus cells were seen in the majority of rats; and few rats showed no obvious pathological changes in lymph nodes; see Figure 5.

Bottom Line: At various time points after operation, the pathological changes in mesenteric lymph nodes of rats in each group were observed, respectively.The pathological severity scores in lymph nodes of SAP rats in treated group were significantly lower than those in model control group (P < .05) while the pathological changes in lymph nodes of OJ rats in treated group also showed varying degrees of mitigation.Salvia miltiorrhizae can exert protective effects on the lymph nodes of SAP or OJ rats via a mechanism that is associated with reducing the contents of inflammatory mediators in blood.

View Article: PubMed Central - PubMed

Affiliation: Department of General Surgery, Hangzhou First People's Hospital, Zhejiang Province, Hangzhou 310006, China.

ABSTRACT

Objective: To observe the effect of salvia miltiorrhizae injection on inflammatory mediator levels and mesenteric lymph nodes in severe acute pancreatitis (SAP) and obstructive jaundice (OJ) rats and explore the protective mechanism of salvia miltiorrhizae on the lymph nodes of these rats.

Methods: A total of 288 rats were used in SAP-associated and OJ-associated experiments. The rats were randomly divided into sham-operated group, model control group, and treated group. At various time points after operation, the pathological changes in mesenteric lymph nodes of rats in each group were observed, respectively.

Results: The pathological severity scores in lymph nodes of SAP rats in treated group were significantly lower than those in model control group (P < .05) while the pathological changes in lymph nodes of OJ rats in treated group also showed varying degrees of mitigation.

Conclusion: Salvia miltiorrhizae can exert protective effects on the lymph nodes of SAP or OJ rats via a mechanism that is associated with reducing the contents of inflammatory mediators in blood.

Show MeSH
Related in: MedlinePlus