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Influence of Salvia miltiorrhizae on the mesenteric lymph node of rats with severe acute pancreatitis or obstructive jaundice.

Xiping Z, Jie Z, Shuyun Y, Qili W, Guanghua F, Yan P - Mediators Inflamm. (2010)

Bottom Line: At various time points after operation, the pathological changes in mesenteric lymph nodes of rats in each group were observed, respectively.The pathological severity scores in lymph nodes of SAP rats in treated group were significantly lower than those in model control group (P < .05) while the pathological changes in lymph nodes of OJ rats in treated group also showed varying degrees of mitigation.Salvia miltiorrhizae can exert protective effects on the lymph nodes of SAP or OJ rats via a mechanism that is associated with reducing the contents of inflammatory mediators in blood.

View Article: PubMed Central - PubMed

Affiliation: Department of General Surgery, Hangzhou First People's Hospital, Zhejiang Province, Hangzhou 310006, China.

ABSTRACT

Objective: To observe the effect of salvia miltiorrhizae injection on inflammatory mediator levels and mesenteric lymph nodes in severe acute pancreatitis (SAP) and obstructive jaundice (OJ) rats and explore the protective mechanism of salvia miltiorrhizae on the lymph nodes of these rats.

Methods: A total of 288 rats were used in SAP-associated and OJ-associated experiments. The rats were randomly divided into sham-operated group, model control group, and treated group. At various time points after operation, the pathological changes in mesenteric lymph nodes of rats in each group were observed, respectively.

Results: The pathological severity scores in lymph nodes of SAP rats in treated group were significantly lower than those in model control group (P < .05) while the pathological changes in lymph nodes of OJ rats in treated group also showed varying degrees of mitigation.

Conclusion: Salvia miltiorrhizae can exert protective effects on the lymph nodes of SAP or OJ rats via a mechanism that is associated with reducing the contents of inflammatory mediators in blood.

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Related in: MedlinePlus

Treated group: 12 hours in SAP rat expansion of lymph sinuses, hyperplasia of sinus cells, and infiltration of small part of some lymphocytes, HE × 200.
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fig3: Treated group: 12 hours in SAP rat expansion of lymph sinuses, hyperplasia of sinus cells, and infiltration of small part of some lymphocytes, HE × 200.

Mentions: Grossly, the morphology of lymph nodes was roughly normal. Under light microscopy, the pathological changes were slightly mitigated when compared with those in model control group. Under electron microscopy, the swelling, disappearance, and vacuolation of few mitochondria were seen; see Figure 3.


Influence of Salvia miltiorrhizae on the mesenteric lymph node of rats with severe acute pancreatitis or obstructive jaundice.

Xiping Z, Jie Z, Shuyun Y, Qili W, Guanghua F, Yan P - Mediators Inflamm. (2010)

Treated group: 12 hours in SAP rat expansion of lymph sinuses, hyperplasia of sinus cells, and infiltration of small part of some lymphocytes, HE × 200.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC2822241&req=5

fig3: Treated group: 12 hours in SAP rat expansion of lymph sinuses, hyperplasia of sinus cells, and infiltration of small part of some lymphocytes, HE × 200.
Mentions: Grossly, the morphology of lymph nodes was roughly normal. Under light microscopy, the pathological changes were slightly mitigated when compared with those in model control group. Under electron microscopy, the swelling, disappearance, and vacuolation of few mitochondria were seen; see Figure 3.

Bottom Line: At various time points after operation, the pathological changes in mesenteric lymph nodes of rats in each group were observed, respectively.The pathological severity scores in lymph nodes of SAP rats in treated group were significantly lower than those in model control group (P < .05) while the pathological changes in lymph nodes of OJ rats in treated group also showed varying degrees of mitigation.Salvia miltiorrhizae can exert protective effects on the lymph nodes of SAP or OJ rats via a mechanism that is associated with reducing the contents of inflammatory mediators in blood.

View Article: PubMed Central - PubMed

Affiliation: Department of General Surgery, Hangzhou First People's Hospital, Zhejiang Province, Hangzhou 310006, China.

ABSTRACT

Objective: To observe the effect of salvia miltiorrhizae injection on inflammatory mediator levels and mesenteric lymph nodes in severe acute pancreatitis (SAP) and obstructive jaundice (OJ) rats and explore the protective mechanism of salvia miltiorrhizae on the lymph nodes of these rats.

Methods: A total of 288 rats were used in SAP-associated and OJ-associated experiments. The rats were randomly divided into sham-operated group, model control group, and treated group. At various time points after operation, the pathological changes in mesenteric lymph nodes of rats in each group were observed, respectively.

Results: The pathological severity scores in lymph nodes of SAP rats in treated group were significantly lower than those in model control group (P < .05) while the pathological changes in lymph nodes of OJ rats in treated group also showed varying degrees of mitigation.

Conclusion: Salvia miltiorrhizae can exert protective effects on the lymph nodes of SAP or OJ rats via a mechanism that is associated with reducing the contents of inflammatory mediators in blood.

Show MeSH
Related in: MedlinePlus