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64-Slice CT angiography of the abdominal aorta and abdominal arteries: comparison of the diagnostic efficacy of iobitridol 350 mgI/ml versus iomeprol 400 mgI/ml in a prospective, randomised, double-blind multi-centre trial.

Loewe C, Becker CR, Berletti R, Cametti CA, Caudron J, Coudyzer W, De Mey J, Favat M, Heautot JF, Heye S, Hittinger M, Larralde A, Lestrat JP, Marangoni R, Nieboer K, Reimer P, Schwarz M, Schernthaner M, Lammer J - Eur Radiol (2009)

Bottom Line: Similar results were observed for image quality of arterial walls (84.3 vs. 83.2%).The mean relative changes in arterial enhancement between baseline and arterial phase images showed no statistically significant differences.It also confirmed the high robustness and reliability of this technique across multi-national practices.

View Article: PubMed Central - PubMed

Affiliation: Section of Cardiovascular and Interventional Radiology, Department of Radiology, Medical University Vienna, Waehringer Guertel 18-20, 1090 Vienna, Austria. christian.loewe@meduniwien.ac.at

ABSTRACT

Purpose: The purpose of this study was to assess the influence of iodine concentration on diagnostic efficacy in multi-detector-row computed tomography (MDCT) angiography of the abdominal aorta and abdominal arteries.

Methods: IRB approval and informed consent were obtained. In this double-blind trial, patients were randomised to undergo MDCT angiography of the abdominal arteries during administration of iobitridol (350 mgI/ml) or iomeprol (400 mgI/ml). Each centre applied its own technique for delivery of contrast medium, regardless of iodine concentration. Diagnostic efficacy, image quality, visualisation of the arterial wall and arterial enhancement were evaluated. A total of 153 patients received iobitridol and 154 received iomeprol.

Results: The ability to reach a diagnosis was "satisfactory" to "totally satisfactory" in 152 (99.3%) and 153 (99.4%) patients respectively. Image quality was rated as being "good" to "excellent" in 94.7 and 94.8% segments respectively. Similar results were observed for image quality of arterial walls (84.3 vs. 83.2%). The mean relative changes in arterial enhancement between baseline and arterial phase images showed no statistically significant differences.

Conclusion: This study demonstrated the non-inferiority of the 350 versus 400 mgI/ml iodine concentration, in terms of diagnostic efficacy, in abdominal MDCT angiography. It also confirmed the high robustness and reliability of this technique across multi-national practices.

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Related in: MedlinePlus

Two examples of abdominal aortic angiograms (maximum intensity projections, MIP) obtained during the administration of two contrast agents. The patient in a was examined during administration of 100 ml iobitridol 350 mgI/ml, and the patient in b received 100 ml iomeprol 400 mgI/ml. Regardless of the different total amounts of iodine, both MIPs show excellent and homogeneous arterial enhancement without visualised differences
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Fig2: Two examples of abdominal aortic angiograms (maximum intensity projections, MIP) obtained during the administration of two contrast agents. The patient in a was examined during administration of 100 ml iobitridol 350 mgI/ml, and the patient in b received 100 ml iomeprol 400 mgI/ml. Regardless of the different total amounts of iodine, both MIPs show excellent and homogeneous arterial enhancement without visualised differences

Mentions: Of the 2,448 vascular segments assessed in the iobitridol group and 2,464 in the iomeprol group, 2,319 (94.7%) and 2,336 (94.8%) were rated as being of “good” to “excellent” image quality respectively. Differences between the two groups were statistically not significant (P = 0.5769), and 95% confidence intervals were small enough to conclude the equivalence of both contrast agents (Table 4; Fig. 2).Fig. 2


64-Slice CT angiography of the abdominal aorta and abdominal arteries: comparison of the diagnostic efficacy of iobitridol 350 mgI/ml versus iomeprol 400 mgI/ml in a prospective, randomised, double-blind multi-centre trial.

Loewe C, Becker CR, Berletti R, Cametti CA, Caudron J, Coudyzer W, De Mey J, Favat M, Heautot JF, Heye S, Hittinger M, Larralde A, Lestrat JP, Marangoni R, Nieboer K, Reimer P, Schwarz M, Schernthaner M, Lammer J - Eur Radiol (2009)

Two examples of abdominal aortic angiograms (maximum intensity projections, MIP) obtained during the administration of two contrast agents. The patient in a was examined during administration of 100 ml iobitridol 350 mgI/ml, and the patient in b received 100 ml iomeprol 400 mgI/ml. Regardless of the different total amounts of iodine, both MIPs show excellent and homogeneous arterial enhancement without visualised differences
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC2822224&req=5

Fig2: Two examples of abdominal aortic angiograms (maximum intensity projections, MIP) obtained during the administration of two contrast agents. The patient in a was examined during administration of 100 ml iobitridol 350 mgI/ml, and the patient in b received 100 ml iomeprol 400 mgI/ml. Regardless of the different total amounts of iodine, both MIPs show excellent and homogeneous arterial enhancement without visualised differences
Mentions: Of the 2,448 vascular segments assessed in the iobitridol group and 2,464 in the iomeprol group, 2,319 (94.7%) and 2,336 (94.8%) were rated as being of “good” to “excellent” image quality respectively. Differences between the two groups were statistically not significant (P = 0.5769), and 95% confidence intervals were small enough to conclude the equivalence of both contrast agents (Table 4; Fig. 2).Fig. 2

Bottom Line: Similar results were observed for image quality of arterial walls (84.3 vs. 83.2%).The mean relative changes in arterial enhancement between baseline and arterial phase images showed no statistically significant differences.It also confirmed the high robustness and reliability of this technique across multi-national practices.

View Article: PubMed Central - PubMed

Affiliation: Section of Cardiovascular and Interventional Radiology, Department of Radiology, Medical University Vienna, Waehringer Guertel 18-20, 1090 Vienna, Austria. christian.loewe@meduniwien.ac.at

ABSTRACT

Purpose: The purpose of this study was to assess the influence of iodine concentration on diagnostic efficacy in multi-detector-row computed tomography (MDCT) angiography of the abdominal aorta and abdominal arteries.

Methods: IRB approval and informed consent were obtained. In this double-blind trial, patients were randomised to undergo MDCT angiography of the abdominal arteries during administration of iobitridol (350 mgI/ml) or iomeprol (400 mgI/ml). Each centre applied its own technique for delivery of contrast medium, regardless of iodine concentration. Diagnostic efficacy, image quality, visualisation of the arterial wall and arterial enhancement were evaluated. A total of 153 patients received iobitridol and 154 received iomeprol.

Results: The ability to reach a diagnosis was "satisfactory" to "totally satisfactory" in 152 (99.3%) and 153 (99.4%) patients respectively. Image quality was rated as being "good" to "excellent" in 94.7 and 94.8% segments respectively. Similar results were observed for image quality of arterial walls (84.3 vs. 83.2%). The mean relative changes in arterial enhancement between baseline and arterial phase images showed no statistically significant differences.

Conclusion: This study demonstrated the non-inferiority of the 350 versus 400 mgI/ml iodine concentration, in terms of diagnostic efficacy, in abdominal MDCT angiography. It also confirmed the high robustness and reliability of this technique across multi-national practices.

Show MeSH
Related in: MedlinePlus