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64-Slice CT angiography of the abdominal aorta and abdominal arteries: comparison of the diagnostic efficacy of iobitridol 350 mgI/ml versus iomeprol 400 mgI/ml in a prospective, randomised, double-blind multi-centre trial.

Loewe C, Becker CR, Berletti R, Cametti CA, Caudron J, Coudyzer W, De Mey J, Favat M, Heautot JF, Heye S, Hittinger M, Larralde A, Lestrat JP, Marangoni R, Nieboer K, Reimer P, Schwarz M, Schernthaner M, Lammer J - Eur Radiol (2009)

Bottom Line: Similar results were observed for image quality of arterial walls (84.3 vs. 83.2%).The mean relative changes in arterial enhancement between baseline and arterial phase images showed no statistically significant differences.It also confirmed the high robustness and reliability of this technique across multi-national practices.

View Article: PubMed Central - PubMed

Affiliation: Section of Cardiovascular and Interventional Radiology, Department of Radiology, Medical University Vienna, Waehringer Guertel 18-20, 1090 Vienna, Austria. christian.loewe@meduniwien.ac.at

ABSTRACT

Purpose: The purpose of this study was to assess the influence of iodine concentration on diagnostic efficacy in multi-detector-row computed tomography (MDCT) angiography of the abdominal aorta and abdominal arteries.

Methods: IRB approval and informed consent were obtained. In this double-blind trial, patients were randomised to undergo MDCT angiography of the abdominal arteries during administration of iobitridol (350 mgI/ml) or iomeprol (400 mgI/ml). Each centre applied its own technique for delivery of contrast medium, regardless of iodine concentration. Diagnostic efficacy, image quality, visualisation of the arterial wall and arterial enhancement were evaluated. A total of 153 patients received iobitridol and 154 received iomeprol.

Results: The ability to reach a diagnosis was "satisfactory" to "totally satisfactory" in 152 (99.3%) and 153 (99.4%) patients respectively. Image quality was rated as being "good" to "excellent" in 94.7 and 94.8% segments respectively. Similar results were observed for image quality of arterial walls (84.3 vs. 83.2%). The mean relative changes in arterial enhancement between baseline and arterial phase images showed no statistically significant differences.

Conclusion: This study demonstrated the non-inferiority of the 350 versus 400 mgI/ml iodine concentration, in terms of diagnostic efficacy, in abdominal MDCT angiography. It also confirmed the high robustness and reliability of this technique across multi-national practices.

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Related in: MedlinePlus

Principle of the measurement of arterial enhancement in the region of the suprarenal aorta, demonstrated in a patient examined with administration of 100 ml iobitridol because of infrarenal aortic aneurysm. Region of interest (ROI) is defined at the same table position in the baseline examination (a) as well as in the arterial phase images (b), as round surfaces in the lumen of the vessel, the circumference of which should not extend beyond the internal limit of the arterial wall
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Fig1: Principle of the measurement of arterial enhancement in the region of the suprarenal aorta, demonstrated in a patient examined with administration of 100 ml iobitridol because of infrarenal aortic aneurysm. Region of interest (ROI) is defined at the same table position in the baseline examination (a) as well as in the arterial phase images (b), as round surfaces in the lumen of the vessel, the circumference of which should not extend beyond the internal limit of the arterial wall

Mentions: As an additional endpoint, arterial enhancement was measured in eight predefined areas, including the suprarenal and the infrarenal aorta, the right and left renal artery, the right and left common iliac artery, and the right and left common femoral artery, and compared between the two groups. For measurement purposes, regions of interest (ROIs) were defined on unenhanced as well as enhanced images in the same table position (Fig. 1). According to the study protocol, the circumference of the ROI should not extend beyond the internal limit of the arterial wall. For the aorta, the ROI was to be located in the middle of the vessel and for its branches in the first 2 cm (Fig. 1). The two groups’ average absolute and relative enhancements were compared.Fig. 1a, b


64-Slice CT angiography of the abdominal aorta and abdominal arteries: comparison of the diagnostic efficacy of iobitridol 350 mgI/ml versus iomeprol 400 mgI/ml in a prospective, randomised, double-blind multi-centre trial.

Loewe C, Becker CR, Berletti R, Cametti CA, Caudron J, Coudyzer W, De Mey J, Favat M, Heautot JF, Heye S, Hittinger M, Larralde A, Lestrat JP, Marangoni R, Nieboer K, Reimer P, Schwarz M, Schernthaner M, Lammer J - Eur Radiol (2009)

Principle of the measurement of arterial enhancement in the region of the suprarenal aorta, demonstrated in a patient examined with administration of 100 ml iobitridol because of infrarenal aortic aneurysm. Region of interest (ROI) is defined at the same table position in the baseline examination (a) as well as in the arterial phase images (b), as round surfaces in the lumen of the vessel, the circumference of which should not extend beyond the internal limit of the arterial wall
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC2822224&req=5

Fig1: Principle of the measurement of arterial enhancement in the region of the suprarenal aorta, demonstrated in a patient examined with administration of 100 ml iobitridol because of infrarenal aortic aneurysm. Region of interest (ROI) is defined at the same table position in the baseline examination (a) as well as in the arterial phase images (b), as round surfaces in the lumen of the vessel, the circumference of which should not extend beyond the internal limit of the arterial wall
Mentions: As an additional endpoint, arterial enhancement was measured in eight predefined areas, including the suprarenal and the infrarenal aorta, the right and left renal artery, the right and left common iliac artery, and the right and left common femoral artery, and compared between the two groups. For measurement purposes, regions of interest (ROIs) were defined on unenhanced as well as enhanced images in the same table position (Fig. 1). According to the study protocol, the circumference of the ROI should not extend beyond the internal limit of the arterial wall. For the aorta, the ROI was to be located in the middle of the vessel and for its branches in the first 2 cm (Fig. 1). The two groups’ average absolute and relative enhancements were compared.Fig. 1a, b

Bottom Line: Similar results were observed for image quality of arterial walls (84.3 vs. 83.2%).The mean relative changes in arterial enhancement between baseline and arterial phase images showed no statistically significant differences.It also confirmed the high robustness and reliability of this technique across multi-national practices.

View Article: PubMed Central - PubMed

Affiliation: Section of Cardiovascular and Interventional Radiology, Department of Radiology, Medical University Vienna, Waehringer Guertel 18-20, 1090 Vienna, Austria. christian.loewe@meduniwien.ac.at

ABSTRACT

Purpose: The purpose of this study was to assess the influence of iodine concentration on diagnostic efficacy in multi-detector-row computed tomography (MDCT) angiography of the abdominal aorta and abdominal arteries.

Methods: IRB approval and informed consent were obtained. In this double-blind trial, patients were randomised to undergo MDCT angiography of the abdominal arteries during administration of iobitridol (350 mgI/ml) or iomeprol (400 mgI/ml). Each centre applied its own technique for delivery of contrast medium, regardless of iodine concentration. Diagnostic efficacy, image quality, visualisation of the arterial wall and arterial enhancement were evaluated. A total of 153 patients received iobitridol and 154 received iomeprol.

Results: The ability to reach a diagnosis was "satisfactory" to "totally satisfactory" in 152 (99.3%) and 153 (99.4%) patients respectively. Image quality was rated as being "good" to "excellent" in 94.7 and 94.8% segments respectively. Similar results were observed for image quality of arterial walls (84.3 vs. 83.2%). The mean relative changes in arterial enhancement between baseline and arterial phase images showed no statistically significant differences.

Conclusion: This study demonstrated the non-inferiority of the 350 versus 400 mgI/ml iodine concentration, in terms of diagnostic efficacy, in abdominal MDCT angiography. It also confirmed the high robustness and reliability of this technique across multi-national practices.

Show MeSH
Related in: MedlinePlus