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Evaluation of methylene diphenyl diisocyanate as an indoor air pollutant and biological assessment of methylene dianiline in the polyurethane factories.

Mirmohammadi M, Ibrahim MH, Ahmad A, Kadir MO, Mohammadyan M, Mirashrafi SB - Indian J Occup Environ Med (2009)

Bottom Line: Today many raw materials used in factories may have a dangerous effect on the physiological system of workers.The concentration of MDI in all air samples was more than 88 mug/m(3), showing a high concentration of the pollutant in the workplaces in comparison with the NIOSH standard, and all the worker's urine was contaminated by MDA.The correlation and regression tests were used to obtain statistical model for MDI and MDA that is useful for prediction of diisocyanates pollution situation in the polyurethane factories.

View Article: PubMed Central - PubMed

Affiliation: School of Industrial Technology, University Science Malaysia, 11800, Pulau Pinang, Malaysia.

ABSTRACT
Today many raw materials used in factories may have a dangerous effect on the physiological system of workers. One of them, which is widely used in the polyurethane factories, is diisocyanates. These compounds are widely used in surface coatings, polyurethane foams, adhesives, resins, elastomers, binders, and sealants. Exposure to diisocyanates causes irritation to the skin, mucous membranes, eyes, and respiratory tract. Methylene dianiline (MDA) is a metabolite of methylene diphenyle diisocyanate (MDI), an excretory material of worker's urine who are exposed to MDI. Around 100 air samples were collected among five factories by the Midget Impinger, which contained DMSO absorbent as a solvent and Tryptamine as a reagent. Samples were analyzed by high-performance liquid chromatography with an EC\UV detector using the NIOSH 5522 method of sampling and analysis. Also, fifty urine samples were collected from workers by using William's biological analysis method. The concentration of MDI in all air samples was more than 88 mug/m(3), showing a high concentration of the pollutant in the workplaces in comparison with the NIOSH standard, and all the worker's urine was contaminated by MDA. The correlation and regression tests were used to obtain statistical model for MDI and MDA that is useful for prediction of diisocyanates pollution situation in the polyurethane factories.

No MeSH data available.


Related in: MedlinePlus

MDI chromatogram by HPLC
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Figure 0001: MDI chromatogram by HPLC

Mentions: A total of five factories of Iran were selected, which have about 500 workers, the factories produce foaming or polyurethane foams and the workers are exposed to MDI through indoor air pollution. There were some workers who do not work fulltime in the workplace. They work as an officer and sometimes people coming and going into the workplace as unexposed workers were also included. The air sampling and analysis of isocyanates from indoor air are divided into four steps: collection, derivatization, sample preparation, and identification.[5] Samplers have been calibrated by a flam flow meter. The Midget Impinger SKC glass personal inhalable sampler (SKC, Houston, TX 77095-5027 USA), with a mini personal sampler pump SIBATA was used. All the samplers with the midget impinger connected to the mini personal sampler pump were fixed to work stations near the source of pollution. The air sample was collected in three working shifts for 2 h at a flow rate 2 L/min in an impinger containing a solution of reagent in DMSO in addition with tryptamine.[5] The air samples were collected at the every 2 h of the work shift. After passing 120 L of air, the entire sample medium was transferred to the laboratory for analysis. Sample handling and preparation were carried out to make it compatible with the analytical procedure as per standard methods. The first step in the analysis of a solution is derivatization of isocyanates for the separation through high-performance liquid chromatography (HPLC) for their qualitative as well as quantitative analysis [Figure 1].


Evaluation of methylene diphenyl diisocyanate as an indoor air pollutant and biological assessment of methylene dianiline in the polyurethane factories.

Mirmohammadi M, Ibrahim MH, Ahmad A, Kadir MO, Mohammadyan M, Mirashrafi SB - Indian J Occup Environ Med (2009)

MDI chromatogram by HPLC
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC2822168&req=5

Figure 0001: MDI chromatogram by HPLC
Mentions: A total of five factories of Iran were selected, which have about 500 workers, the factories produce foaming or polyurethane foams and the workers are exposed to MDI through indoor air pollution. There were some workers who do not work fulltime in the workplace. They work as an officer and sometimes people coming and going into the workplace as unexposed workers were also included. The air sampling and analysis of isocyanates from indoor air are divided into four steps: collection, derivatization, sample preparation, and identification.[5] Samplers have been calibrated by a flam flow meter. The Midget Impinger SKC glass personal inhalable sampler (SKC, Houston, TX 77095-5027 USA), with a mini personal sampler pump SIBATA was used. All the samplers with the midget impinger connected to the mini personal sampler pump were fixed to work stations near the source of pollution. The air sample was collected in three working shifts for 2 h at a flow rate 2 L/min in an impinger containing a solution of reagent in DMSO in addition with tryptamine.[5] The air samples were collected at the every 2 h of the work shift. After passing 120 L of air, the entire sample medium was transferred to the laboratory for analysis. Sample handling and preparation were carried out to make it compatible with the analytical procedure as per standard methods. The first step in the analysis of a solution is derivatization of isocyanates for the separation through high-performance liquid chromatography (HPLC) for their qualitative as well as quantitative analysis [Figure 1].

Bottom Line: Today many raw materials used in factories may have a dangerous effect on the physiological system of workers.The concentration of MDI in all air samples was more than 88 mug/m(3), showing a high concentration of the pollutant in the workplaces in comparison with the NIOSH standard, and all the worker's urine was contaminated by MDA.The correlation and regression tests were used to obtain statistical model for MDI and MDA that is useful for prediction of diisocyanates pollution situation in the polyurethane factories.

View Article: PubMed Central - PubMed

Affiliation: School of Industrial Technology, University Science Malaysia, 11800, Pulau Pinang, Malaysia.

ABSTRACT
Today many raw materials used in factories may have a dangerous effect on the physiological system of workers. One of them, which is widely used in the polyurethane factories, is diisocyanates. These compounds are widely used in surface coatings, polyurethane foams, adhesives, resins, elastomers, binders, and sealants. Exposure to diisocyanates causes irritation to the skin, mucous membranes, eyes, and respiratory tract. Methylene dianiline (MDA) is a metabolite of methylene diphenyle diisocyanate (MDI), an excretory material of worker's urine who are exposed to MDI. Around 100 air samples were collected among five factories by the Midget Impinger, which contained DMSO absorbent as a solvent and Tryptamine as a reagent. Samples were analyzed by high-performance liquid chromatography with an EC\UV detector using the NIOSH 5522 method of sampling and analysis. Also, fifty urine samples were collected from workers by using William's biological analysis method. The concentration of MDI in all air samples was more than 88 mug/m(3), showing a high concentration of the pollutant in the workplaces in comparison with the NIOSH standard, and all the worker's urine was contaminated by MDA. The correlation and regression tests were used to obtain statistical model for MDI and MDA that is useful for prediction of diisocyanates pollution situation in the polyurethane factories.

No MeSH data available.


Related in: MedlinePlus