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ATP-Binding Cassette Systems of Brucella.

Jenner DC, Dassa E, Whatmore AM, Atkins HS - Comp. Funct. Genomics (2010)

Bottom Line: In this study, complete inventories of putative functional ABC systems of five Brucella species have been compiled and compared.High numbers of ABC systems, particularly nutrient importers, were found in all Brucella species.However, differences in the total numbers of ABC systems were identified (B. melitensis, 79; B. suis, 72; B. abortus 64; B. canis, 74; B. ovis, 59) as well as specific differences in the functional ABC systems of the Brucella species.

View Article: PubMed Central - PubMed

Affiliation: Department of Biomedical Sciences, Defence Science and Technology Laboratory, Porton Down, Salisbury, Wiltshire SP4 0JQ, UK.

ABSTRACT
Brucellosis is a prevalent zoonotic disease and is endemic in the Middle East, South America, and other areas of the world. In this study, complete inventories of putative functional ABC systems of five Brucella species have been compiled and compared. ABC systems of Brucella melitensis 16M, Brucella abortus 9-941, Brucella canis RM6/66, Brucella suis 1330, and Brucella ovis 63/290 were identified and aligned. High numbers of ABC systems, particularly nutrient importers, were found in all Brucella species. However, differences in the total numbers of ABC systems were identified (B. melitensis, 79; B. suis, 72; B. abortus 64; B. canis, 74; B. ovis, 59) as well as specific differences in the functional ABC systems of the Brucella species. Since B. ovis is not known to cause human brucellosis, functional ABC systems absent in the B. ovis genome may represent virulence factors in human brucellosis.

No MeSH data available.


Related in: MedlinePlus

ABC system class/family-subfamily.
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Related In: Results  -  Collection


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fig1: ABC system class/family-subfamily.

Mentions: The predicted functionality of the ABC systems within the Brucella genomes is dominated by ABC systems involved in the import of nutrients (Figure 1), and although this is not uncommon amongst bacteria, it is probable that Brucella species utilise ABC transporters to provide most of the nutrients they require [8, 39]. In support of the findings of Paulsen et al. [9], the 2.1 Mb chromosome encodes a large proportion of the ABC systems involved in molecular export and cellular process whereas the ABC systems located on the smaller chromosome are largely biased toward nutrient acquisition, leading to the idea that this second chromosome is important in the acquisition and processing of nutrients in Brucella.


ATP-Binding Cassette Systems of Brucella.

Jenner DC, Dassa E, Whatmore AM, Atkins HS - Comp. Funct. Genomics (2010)

ABC system class/family-subfamily.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC2821768&req=5

fig1: ABC system class/family-subfamily.
Mentions: The predicted functionality of the ABC systems within the Brucella genomes is dominated by ABC systems involved in the import of nutrients (Figure 1), and although this is not uncommon amongst bacteria, it is probable that Brucella species utilise ABC transporters to provide most of the nutrients they require [8, 39]. In support of the findings of Paulsen et al. [9], the 2.1 Mb chromosome encodes a large proportion of the ABC systems involved in molecular export and cellular process whereas the ABC systems located on the smaller chromosome are largely biased toward nutrient acquisition, leading to the idea that this second chromosome is important in the acquisition and processing of nutrients in Brucella.

Bottom Line: In this study, complete inventories of putative functional ABC systems of five Brucella species have been compiled and compared.High numbers of ABC systems, particularly nutrient importers, were found in all Brucella species.However, differences in the total numbers of ABC systems were identified (B. melitensis, 79; B. suis, 72; B. abortus 64; B. canis, 74; B. ovis, 59) as well as specific differences in the functional ABC systems of the Brucella species.

View Article: PubMed Central - PubMed

Affiliation: Department of Biomedical Sciences, Defence Science and Technology Laboratory, Porton Down, Salisbury, Wiltshire SP4 0JQ, UK.

ABSTRACT
Brucellosis is a prevalent zoonotic disease and is endemic in the Middle East, South America, and other areas of the world. In this study, complete inventories of putative functional ABC systems of five Brucella species have been compiled and compared. ABC systems of Brucella melitensis 16M, Brucella abortus 9-941, Brucella canis RM6/66, Brucella suis 1330, and Brucella ovis 63/290 were identified and aligned. High numbers of ABC systems, particularly nutrient importers, were found in all Brucella species. However, differences in the total numbers of ABC systems were identified (B. melitensis, 79; B. suis, 72; B. abortus 64; B. canis, 74; B. ovis, 59) as well as specific differences in the functional ABC systems of the Brucella species. Since B. ovis is not known to cause human brucellosis, functional ABC systems absent in the B. ovis genome may represent virulence factors in human brucellosis.

No MeSH data available.


Related in: MedlinePlus