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Blood Pressure and Left Ventricular Characteristics in Young Patients with Classical Congenital Adrenal Hyperplasia due to 21-Hydroxylase Deficiency.

Ubertini G, Bizzarri C, Grossi A, Gimigliano F, Ravà L, Fintini D, Cappa M - Int J Pediatr Endocrinol (2010)

Bottom Line: Left ventricular mass (LVM ) was affected by height SDS (P: .007, 95% CI: 2.67 to 14.17, beta = 8.42), age (P: < .0001, 95% CI: 2.12 to 5.82, beta = 3.97), and testosterone (P: .008, 95% CI: 0.01 to 0.09, beta = 0.053).Left ventricular mass index (LVMI) correlated with BMI SDS (P: .044, 95% CI: 0.09 to 6.17, beta = 3.13) and testosterone (P: .031, 95% CI: 0.002 to 0.035, beta = 0.018).Hydrocortisone dose did not influence ambBP, excBP, or myocardial hypertrophy.

View Article: PubMed Central - PubMed

Affiliation: Department of Pediatrics, Unit of Endocrinology and Diabetes, Bambino Gesù Children's Hospital, School of Medicine, University of Rome Tor Vergata, P.zza S. Onofrio 4, 00165 Rome, Italy.

ABSTRACT
High steroid doses are often necessary in congenital adrenal hyperplasia (CAH) to suppress androgens and may increase blood pressure (BP). We evaluated 24-hour BP profile (ambBP), BP during exercise (excBP), and echocardiography in 20 young CAH patients. Systolic and diastolic BP during ambBP and excBP was normal in all patients. None presented myocardial hypertrophy. Nocturnal diastolic BP was affected by testosterone (P: .016, 95% CI: 0.002 to 0.021, beta = 0.01). Left ventricular mass (LVM ) was affected by height SDS (P: .007, 95% CI: 2.67 to 14.17, beta = 8.42), age (P: < .0001, 95% CI: 2.12 to 5.82, beta = 3.97), and testosterone (P: .008, 95% CI: 0.01 to 0.09, beta = 0.053). Left ventricular mass index (LVMI) correlated with BMI SDS (P: .044, 95% CI: 0.09 to 6.17, beta = 3.13) and testosterone (P: .031, 95% CI: 0.002 to 0.035, beta = 0.018). Hydrocortisone dose did not influence ambBP, excBP, or myocardial hypertrophy.

No MeSH data available.


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Correlation between BMI SDS and LVMI (P: 0.044).
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fig1: Correlation between BMI SDS and LVMI (P: 0.044).

Mentions: Multivariable linear regression showed that mean diurnal SBP, from the 24-hour ambBP profile, was negatively related to 17-OH-progesterone levels (P: .026, 95% CI: −0.34 to −0.02, β = −0.18), while mean diurnal DBP was positively related to age (P: .003, 95% CI: 0.29 to 1.28, β = 0.79) and to height SDS (P: .029, 95% CI: 0.22 to 3.52, β = 1.87). Mean nocturnal DBP was affected by testosterone levels (P: .016, 95% CI: 0.002 to 0.021, β = 0.01). SBP at maximal heart rate during exercise was influenced by age (P < .0001, 95% CI: 1.79 to 4.67, β = 3.23), whereas DBP showed a correlation both with age (P: < .0001, 95% CI: 1.30 to 3.03, β = 2.20) and with BMI SDS (P: .033, 95% CI: 0.40 to 8.76, β = 4.58). No CAH patient presented left ventricular hypertrophy, defined by the published paediatric criteria (LVMI >38.6 g/m2.7). Multivariable linear regression showed that LVM was affected by height SDS (P: .007, 95% CI: 2.67 to 14.17, β = 8.42), by age (P:<.0001, 95% CI: 2.12 to 5.82, β = 3.87) and by testosterone levels (P: .008, 95% CI: 0.01 to 0.09, β = 0.053). LVMI was positively related to BMI SDS (P: .044, 95% CI: 0.09 to 6.17, β = 3.13—Figure 1), and to testosterone levels (P: .031, 95% CI: 0.002 to 0.035, β = 0.018). LVPW was affected only by age (P: .008, 95% CI: 0.03 to 0.19, β = 0.11).


Blood Pressure and Left Ventricular Characteristics in Young Patients with Classical Congenital Adrenal Hyperplasia due to 21-Hydroxylase Deficiency.

Ubertini G, Bizzarri C, Grossi A, Gimigliano F, Ravà L, Fintini D, Cappa M - Int J Pediatr Endocrinol (2010)

Correlation between BMI SDS and LVMI (P: 0.044).
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC2821643&req=5

fig1: Correlation between BMI SDS and LVMI (P: 0.044).
Mentions: Multivariable linear regression showed that mean diurnal SBP, from the 24-hour ambBP profile, was negatively related to 17-OH-progesterone levels (P: .026, 95% CI: −0.34 to −0.02, β = −0.18), while mean diurnal DBP was positively related to age (P: .003, 95% CI: 0.29 to 1.28, β = 0.79) and to height SDS (P: .029, 95% CI: 0.22 to 3.52, β = 1.87). Mean nocturnal DBP was affected by testosterone levels (P: .016, 95% CI: 0.002 to 0.021, β = 0.01). SBP at maximal heart rate during exercise was influenced by age (P < .0001, 95% CI: 1.79 to 4.67, β = 3.23), whereas DBP showed a correlation both with age (P: < .0001, 95% CI: 1.30 to 3.03, β = 2.20) and with BMI SDS (P: .033, 95% CI: 0.40 to 8.76, β = 4.58). No CAH patient presented left ventricular hypertrophy, defined by the published paediatric criteria (LVMI >38.6 g/m2.7). Multivariable linear regression showed that LVM was affected by height SDS (P: .007, 95% CI: 2.67 to 14.17, β = 8.42), by age (P:<.0001, 95% CI: 2.12 to 5.82, β = 3.87) and by testosterone levels (P: .008, 95% CI: 0.01 to 0.09, β = 0.053). LVMI was positively related to BMI SDS (P: .044, 95% CI: 0.09 to 6.17, β = 3.13—Figure 1), and to testosterone levels (P: .031, 95% CI: 0.002 to 0.035, β = 0.018). LVPW was affected only by age (P: .008, 95% CI: 0.03 to 0.19, β = 0.11).

Bottom Line: Left ventricular mass (LVM ) was affected by height SDS (P: .007, 95% CI: 2.67 to 14.17, beta = 8.42), age (P: < .0001, 95% CI: 2.12 to 5.82, beta = 3.97), and testosterone (P: .008, 95% CI: 0.01 to 0.09, beta = 0.053).Left ventricular mass index (LVMI) correlated with BMI SDS (P: .044, 95% CI: 0.09 to 6.17, beta = 3.13) and testosterone (P: .031, 95% CI: 0.002 to 0.035, beta = 0.018).Hydrocortisone dose did not influence ambBP, excBP, or myocardial hypertrophy.

View Article: PubMed Central - PubMed

Affiliation: Department of Pediatrics, Unit of Endocrinology and Diabetes, Bambino Gesù Children's Hospital, School of Medicine, University of Rome Tor Vergata, P.zza S. Onofrio 4, 00165 Rome, Italy.

ABSTRACT
High steroid doses are often necessary in congenital adrenal hyperplasia (CAH) to suppress androgens and may increase blood pressure (BP). We evaluated 24-hour BP profile (ambBP), BP during exercise (excBP), and echocardiography in 20 young CAH patients. Systolic and diastolic BP during ambBP and excBP was normal in all patients. None presented myocardial hypertrophy. Nocturnal diastolic BP was affected by testosterone (P: .016, 95% CI: 0.002 to 0.021, beta = 0.01). Left ventricular mass (LVM ) was affected by height SDS (P: .007, 95% CI: 2.67 to 14.17, beta = 8.42), age (P: < .0001, 95% CI: 2.12 to 5.82, beta = 3.97), and testosterone (P: .008, 95% CI: 0.01 to 0.09, beta = 0.053). Left ventricular mass index (LVMI) correlated with BMI SDS (P: .044, 95% CI: 0.09 to 6.17, beta = 3.13) and testosterone (P: .031, 95% CI: 0.002 to 0.035, beta = 0.018). Hydrocortisone dose did not influence ambBP, excBP, or myocardial hypertrophy.

No MeSH data available.


Related in: MedlinePlus