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Melanotic neuroectodermal tumor of infancy: discussion of a case and a review of the imaging findings.

Nazira B, Gupta H, Chaturvedi AK, Rao SA, Jena A - Cancer Imaging (2009)

Bottom Line: Melanotic neuroectodermal tumor of infancy (MNTI) is an uncommon melanin-containing mesenchymal tumor of neural crest origin.What make this tumor unique and interesting is its characteristic predilection for anterior maxilla (premaxilla) and the presence of pigment melanin which gives the tumor distinct clinicopathological, immunohistochemical, ultrastructural and imaging features.The pool of documented radiological findings is even more sparse as not more than a dozen cases could be abstracted from an Internet search of the radiology literature.

View Article: PubMed Central - PubMed

Affiliation: Departments of Radiology, Rajiv Gandhi Cancer Institute and Research Center, New Delhi, India. bab_nazir@hotmail.com

ABSTRACT
Melanotic neuroectodermal tumor of infancy (MNTI) is an uncommon melanin-containing mesenchymal tumor of neural crest origin. What make this tumor unique and interesting is its characteristic predilection for anterior maxilla (premaxilla) and the presence of pigment melanin which gives the tumor distinct clinicopathological, immunohistochemical, ultrastructural and imaging features. Although first described almost a century ago, to the authors' knowledge, only a few hundred cases of MNTI have been reported worldwide in the English medical literature. The pool of documented radiological findings is even more sparse as not more than a dozen cases could be abstracted from an Internet search of the radiology literature. We document a case of MNTI and describe the imaging findings with intent to contribute to its small but accruing radiological data.

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Related in: MedlinePlus

Histopathological image (magnification 300×; hematoxylin and eosin stain) of the excised mass showing a nest of small cells (small arrow) and larger melanin-containing cells (large arrow) in a fibrous stroma (open arrow).
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Figure 4: Histopathological image (magnification 300×; hematoxylin and eosin stain) of the excised mass showing a nest of small cells (small arrow) and larger melanin-containing cells (large arrow) in a fibrous stroma (open arrow).

Mentions: A core needle biopsy revealed small round cells with peripherally arranged larger pigment-containing cells in alveolar distribution lying in fibrous stroma (Fig. 4). A full panel of immunohistochemistry markers were run on the biopsy tissue, which was strongly reactive for cytokeratin (CK), HMB45 and neuron-specific enolase (NSE) and negative for S-100, CD99 and leukocyte common antigen (LCA), confirming the diagnosis of melanotic neuroectodermal tumor of infancy (MNTI) (Fig. 5).Figure 4


Melanotic neuroectodermal tumor of infancy: discussion of a case and a review of the imaging findings.

Nazira B, Gupta H, Chaturvedi AK, Rao SA, Jena A - Cancer Imaging (2009)

Histopathological image (magnification 300×; hematoxylin and eosin stain) of the excised mass showing a nest of small cells (small arrow) and larger melanin-containing cells (large arrow) in a fibrous stroma (open arrow).
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC2821590&req=5

Figure 4: Histopathological image (magnification 300×; hematoxylin and eosin stain) of the excised mass showing a nest of small cells (small arrow) and larger melanin-containing cells (large arrow) in a fibrous stroma (open arrow).
Mentions: A core needle biopsy revealed small round cells with peripherally arranged larger pigment-containing cells in alveolar distribution lying in fibrous stroma (Fig. 4). A full panel of immunohistochemistry markers were run on the biopsy tissue, which was strongly reactive for cytokeratin (CK), HMB45 and neuron-specific enolase (NSE) and negative for S-100, CD99 and leukocyte common antigen (LCA), confirming the diagnosis of melanotic neuroectodermal tumor of infancy (MNTI) (Fig. 5).Figure 4

Bottom Line: Melanotic neuroectodermal tumor of infancy (MNTI) is an uncommon melanin-containing mesenchymal tumor of neural crest origin.What make this tumor unique and interesting is its characteristic predilection for anterior maxilla (premaxilla) and the presence of pigment melanin which gives the tumor distinct clinicopathological, immunohistochemical, ultrastructural and imaging features.The pool of documented radiological findings is even more sparse as not more than a dozen cases could be abstracted from an Internet search of the radiology literature.

View Article: PubMed Central - PubMed

Affiliation: Departments of Radiology, Rajiv Gandhi Cancer Institute and Research Center, New Delhi, India. bab_nazir@hotmail.com

ABSTRACT
Melanotic neuroectodermal tumor of infancy (MNTI) is an uncommon melanin-containing mesenchymal tumor of neural crest origin. What make this tumor unique and interesting is its characteristic predilection for anterior maxilla (premaxilla) and the presence of pigment melanin which gives the tumor distinct clinicopathological, immunohistochemical, ultrastructural and imaging features. Although first described almost a century ago, to the authors' knowledge, only a few hundred cases of MNTI have been reported worldwide in the English medical literature. The pool of documented radiological findings is even more sparse as not more than a dozen cases could be abstracted from an Internet search of the radiology literature. We document a case of MNTI and describe the imaging findings with intent to contribute to its small but accruing radiological data.

Show MeSH
Related in: MedlinePlus