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Melanotic neuroectodermal tumor of infancy: discussion of a case and a review of the imaging findings.

Nazira B, Gupta H, Chaturvedi AK, Rao SA, Jena A - Cancer Imaging (2009)

Bottom Line: Melanotic neuroectodermal tumor of infancy (MNTI) is an uncommon melanin-containing mesenchymal tumor of neural crest origin.What make this tumor unique and interesting is its characteristic predilection for anterior maxilla (premaxilla) and the presence of pigment melanin which gives the tumor distinct clinicopathological, immunohistochemical, ultrastructural and imaging features.The pool of documented radiological findings is even more sparse as not more than a dozen cases could be abstracted from an Internet search of the radiology literature.

View Article: PubMed Central - PubMed

Affiliation: Departments of Radiology, Rajiv Gandhi Cancer Institute and Research Center, New Delhi, India. bab_nazir@hotmail.com

ABSTRACT
Melanotic neuroectodermal tumor of infancy (MNTI) is an uncommon melanin-containing mesenchymal tumor of neural crest origin. What make this tumor unique and interesting is its characteristic predilection for anterior maxilla (premaxilla) and the presence of pigment melanin which gives the tumor distinct clinicopathological, immunohistochemical, ultrastructural and imaging features. Although first described almost a century ago, to the authors' knowledge, only a few hundred cases of MNTI have been reported worldwide in the English medical literature. The pool of documented radiological findings is even more sparse as not more than a dozen cases could be abstracted from an Internet search of the radiology literature. We document a case of MNTI and describe the imaging findings with intent to contribute to its small but accruing radiological data.

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Axial contrast-enhanced CT scan images in (A) soft-tissue window and (B) bone window settings show an expansile, bilobed, well-circumscribed, solid lesion with epicenter in the anterior maxillary alveolar ridge. Bone margins are continuous, thin, lobulated with areas of sclerosis and hyperostosis. Moderate soft-tissue enhancement is present. Note the displaced developing teeth.
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Figure 2: Axial contrast-enhanced CT scan images in (A) soft-tissue window and (B) bone window settings show an expansile, bilobed, well-circumscribed, solid lesion with epicenter in the anterior maxillary alveolar ridge. Bone margins are continuous, thin, lobulated with areas of sclerosis and hyperostosis. Moderate soft-tissue enhancement is present. Note the displaced developing teeth.

Mentions: Plain digital radiograph showed an expansile lytic bony lesion in the anterior maxilla region. Computed tomography (CT) and magnetic resonance (MR) scans were done to evaluate the lesion. A CT examination of the face was done on a multi-detector computed tomography (MDCT) scanner (Emotion Duo; Siemens Medical Systems, Erlangen, Germany). Contiguous axial 5-mm thick sections were taken. Contrast-enhanced scans were obtained after manual intravenous injection of 20 ml of nonionic Iomeprol (Iomeron-300, Bracco, Ferentino, Italy) containing 300 mg/ml iodine. The CT scan revealed a bilobular, expansile bone lesion with homogenous soft-tissue density content, involving the anterior maxilla and adjacent hard palate, and displacing the developing dentition (Fig. 2). The bone margins were thin, lobulated and continuous with areas of hyperostosis. No calcification was noted. Moderate homogenous enhancement was seen on contrast study.Figure 2


Melanotic neuroectodermal tumor of infancy: discussion of a case and a review of the imaging findings.

Nazira B, Gupta H, Chaturvedi AK, Rao SA, Jena A - Cancer Imaging (2009)

Axial contrast-enhanced CT scan images in (A) soft-tissue window and (B) bone window settings show an expansile, bilobed, well-circumscribed, solid lesion with epicenter in the anterior maxillary alveolar ridge. Bone margins are continuous, thin, lobulated with areas of sclerosis and hyperostosis. Moderate soft-tissue enhancement is present. Note the displaced developing teeth.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC2821590&req=5

Figure 2: Axial contrast-enhanced CT scan images in (A) soft-tissue window and (B) bone window settings show an expansile, bilobed, well-circumscribed, solid lesion with epicenter in the anterior maxillary alveolar ridge. Bone margins are continuous, thin, lobulated with areas of sclerosis and hyperostosis. Moderate soft-tissue enhancement is present. Note the displaced developing teeth.
Mentions: Plain digital radiograph showed an expansile lytic bony lesion in the anterior maxilla region. Computed tomography (CT) and magnetic resonance (MR) scans were done to evaluate the lesion. A CT examination of the face was done on a multi-detector computed tomography (MDCT) scanner (Emotion Duo; Siemens Medical Systems, Erlangen, Germany). Contiguous axial 5-mm thick sections were taken. Contrast-enhanced scans were obtained after manual intravenous injection of 20 ml of nonionic Iomeprol (Iomeron-300, Bracco, Ferentino, Italy) containing 300 mg/ml iodine. The CT scan revealed a bilobular, expansile bone lesion with homogenous soft-tissue density content, involving the anterior maxilla and adjacent hard palate, and displacing the developing dentition (Fig. 2). The bone margins were thin, lobulated and continuous with areas of hyperostosis. No calcification was noted. Moderate homogenous enhancement was seen on contrast study.Figure 2

Bottom Line: Melanotic neuroectodermal tumor of infancy (MNTI) is an uncommon melanin-containing mesenchymal tumor of neural crest origin.What make this tumor unique and interesting is its characteristic predilection for anterior maxilla (premaxilla) and the presence of pigment melanin which gives the tumor distinct clinicopathological, immunohistochemical, ultrastructural and imaging features.The pool of documented radiological findings is even more sparse as not more than a dozen cases could be abstracted from an Internet search of the radiology literature.

View Article: PubMed Central - PubMed

Affiliation: Departments of Radiology, Rajiv Gandhi Cancer Institute and Research Center, New Delhi, India. bab_nazir@hotmail.com

ABSTRACT
Melanotic neuroectodermal tumor of infancy (MNTI) is an uncommon melanin-containing mesenchymal tumor of neural crest origin. What make this tumor unique and interesting is its characteristic predilection for anterior maxilla (premaxilla) and the presence of pigment melanin which gives the tumor distinct clinicopathological, immunohistochemical, ultrastructural and imaging features. Although first described almost a century ago, to the authors' knowledge, only a few hundred cases of MNTI have been reported worldwide in the English medical literature. The pool of documented radiological findings is even more sparse as not more than a dozen cases could be abstracted from an Internet search of the radiology literature. We document a case of MNTI and describe the imaging findings with intent to contribute to its small but accruing radiological data.

Show MeSH
Related in: MedlinePlus