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Pleomorphic adenoma of minor salivary gland with therapeutic misadventure: a rare case report.

Thakur JS, Mohindroo NK, Mohindroo S, Sharma DR, Thakur A - BMC Ear Nose Throat Disord (2010)

Bottom Line: The examination found big mass extending from nasopharynx to oropharynx.The FNAB found it a carcinoma but it did not respond to radiotherapy.A possibility of benign tumor should always be kept in nasopharyngeal growth with no evidence of metastasis, and histopathological diagnosis of growth should be available before any definitive treatment.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Otolaryngology - Head & Neck Surgery, I. G. Medical College, Shimla, HP, 171001, India.

ABSTRACT

Background: The benign tumors of nasopharynx are least encountered tumors in otolaryngology, as nasopharynx is considered one of notorious anatomical site for the malignant tumors. Pleomorphic adenoma of the minor salivary gland of nasopharynx and parapharyngeal space is rare. We present a pleomorphic adenoma of minor salivary gland which was mismanaged.

Case presentation: An adult male presented with left nostril obstruction for five months. The examination found big mass extending from nasopharynx to oropharynx. On CT scan, this tumor was quite big and extending to the parapharyngeal space. The FNAB found it a carcinoma but it did not respond to radiotherapy. The excision biopsy of tumor revealed it as pleomorphic adenoma. We found only five published reports on this tumor arising from nasopharynx.

Discussion and conclusion: Although, in this case report exact origin of the tumor could not be ascertained as it also appeared to be a parapharyngeal tumor but we kept the possibility of a nasopharyngeal tumor on the basis of clinical features. The pleomorphic adenoma of nasopharynx is rare. It can be misdiagnosed as malignant epithelial tumor on histopathology. The differentiation from its malignant variant is also difficult. A possibility of benign tumor should always be kept in nasopharyngeal growth with no evidence of metastasis, and histopathological diagnosis of growth should be available before any definitive treatment.

No MeSH data available.


Related in: MedlinePlus

On 19th Sep 2007, pre-radiotherapy contrast CT scan found heterogeneous enhanced tumor in the nasopharynx with extension up to parapharyngeal area. The tumor had multiple necrotic areas with largest area in its lower part.
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Figure 1: On 19th Sep 2007, pre-radiotherapy contrast CT scan found heterogeneous enhanced tumor in the nasopharynx with extension up to parapharyngeal area. The tumor had multiple necrotic areas with largest area in its lower part.

Mentions: A fine needle aspiration biopsy (FNAB) of the mass was done intra-orally and microscopic examination revealed a poor smear with scanty cells. The pathologist suggested the possibility of a squamous cell carcinoma and advised a direct biopsy for definitive diagnosis. On 19th Sep 2007, computed tomographic (CT) scan of the neck revealed a large mass of heterogeneous density involving the fossa of Rosenmuller, and extending to the valleculla through parapharyngeal space. The mass had heterogeneous contrast enhancement with central necrosis (Fig 1). Based on these features, radiologist suggested a malignant tumor of the nasopharynx.


Pleomorphic adenoma of minor salivary gland with therapeutic misadventure: a rare case report.

Thakur JS, Mohindroo NK, Mohindroo S, Sharma DR, Thakur A - BMC Ear Nose Throat Disord (2010)

On 19th Sep 2007, pre-radiotherapy contrast CT scan found heterogeneous enhanced tumor in the nasopharynx with extension up to parapharyngeal area. The tumor had multiple necrotic areas with largest area in its lower part.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC2821363&req=5

Figure 1: On 19th Sep 2007, pre-radiotherapy contrast CT scan found heterogeneous enhanced tumor in the nasopharynx with extension up to parapharyngeal area. The tumor had multiple necrotic areas with largest area in its lower part.
Mentions: A fine needle aspiration biopsy (FNAB) of the mass was done intra-orally and microscopic examination revealed a poor smear with scanty cells. The pathologist suggested the possibility of a squamous cell carcinoma and advised a direct biopsy for definitive diagnosis. On 19th Sep 2007, computed tomographic (CT) scan of the neck revealed a large mass of heterogeneous density involving the fossa of Rosenmuller, and extending to the valleculla through parapharyngeal space. The mass had heterogeneous contrast enhancement with central necrosis (Fig 1). Based on these features, radiologist suggested a malignant tumor of the nasopharynx.

Bottom Line: The examination found big mass extending from nasopharynx to oropharynx.The FNAB found it a carcinoma but it did not respond to radiotherapy.A possibility of benign tumor should always be kept in nasopharyngeal growth with no evidence of metastasis, and histopathological diagnosis of growth should be available before any definitive treatment.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Otolaryngology - Head & Neck Surgery, I. G. Medical College, Shimla, HP, 171001, India.

ABSTRACT

Background: The benign tumors of nasopharynx are least encountered tumors in otolaryngology, as nasopharynx is considered one of notorious anatomical site for the malignant tumors. Pleomorphic adenoma of the minor salivary gland of nasopharynx and parapharyngeal space is rare. We present a pleomorphic adenoma of minor salivary gland which was mismanaged.

Case presentation: An adult male presented with left nostril obstruction for five months. The examination found big mass extending from nasopharynx to oropharynx. On CT scan, this tumor was quite big and extending to the parapharyngeal space. The FNAB found it a carcinoma but it did not respond to radiotherapy. The excision biopsy of tumor revealed it as pleomorphic adenoma. We found only five published reports on this tumor arising from nasopharynx.

Discussion and conclusion: Although, in this case report exact origin of the tumor could not be ascertained as it also appeared to be a parapharyngeal tumor but we kept the possibility of a nasopharyngeal tumor on the basis of clinical features. The pleomorphic adenoma of nasopharynx is rare. It can be misdiagnosed as malignant epithelial tumor on histopathology. The differentiation from its malignant variant is also difficult. A possibility of benign tumor should always be kept in nasopharyngeal growth with no evidence of metastasis, and histopathological diagnosis of growth should be available before any definitive treatment.

No MeSH data available.


Related in: MedlinePlus