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Inverse relation between FASN expression in human adipose tissue and the insulin resistance level.

Mayas MD, Ortega FJ, Macías-González M, Bernal R, Gómez-Huelgas R, Fernández-Real JM, Tinahones FJ - Nutr Metab (Lond) (2010)

Bottom Line: The study included eighty-seven patients which were classified according to their BMI and to their glycaemia levels in order to study FASN and PPARgamma gene expression levels, anthropometric and biochemical variables.The correlation of the enzyme with these parameters is inversely proportional.On the other hand, PPARgamma is not related to carbohydrate metabolism.

View Article: PubMed Central - HTML - PubMed

Affiliation: Servicio de Endocrinología y Nutrición, Hospital Clínico Universitario Virgen de Victoria de Málaga, España.

ABSTRACT

Background: Adipose tissue is a key regulator of energy balance playing an active role in lipid storage and may be a dynamic buffer to control fatty acid flux. Just like PPARgamma, fatty acid synthesis enzymes such as FASN have been implicated in almost all aspects of human metabolic alterations such as obesity, insulin resistance or dyslipemia. The aim of this work is to investigate how FASN and PPARgamma expression in human adipose tissue is related to carbohydrate metabolism dysfunction and obesity.

Methods: The study included eighty-seven patients which were classified according to their BMI and to their glycaemia levels in order to study FASN and PPARgamma gene expression levels, anthropometric and biochemical variables.

Results: The main result of this work is the close relation between FASN expression level and the factors that lead to hyperglycemic state (increased values of glucose levels, HOMA-IR, HbA1c, BMI and triglycerides). The correlation of the enzyme with these parameters is inversely proportional. On the other hand, PPARgamma is not related to carbohydrate metabolism.

Conclusions: We can demonstrate that FASN expression is a good candidate to study the pathophysiology of type II diabetes and obesity in humans.

No MeSH data available.


Related in: MedlinePlus

Linear relationship between FASN expression and adiponectin (a), BMI (b), HOMA-IR (c) and HbA1c (d). Linear relationship was determined by Pearson's correlation coefficient test. 95% confidence interval.
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Figure 1: Linear relationship between FASN expression and adiponectin (a), BMI (b), HOMA-IR (c) and HbA1c (d). Linear relationship was determined by Pearson's correlation coefficient test. 95% confidence interval.

Mentions: The correlation between FASN expression and the different parameters that are associated with diabetes and obesity have shown the following results: there is a positive correlation of FASN expression with levels of adiponectin (P < 0.05; r = 0.265; Figure 1a) and HDL-c (P < 0.05; r = 0.276). BMI (P < 0.01; r = 0.383; Figure 1b), W-H (P < 0.05; r = 0.274), glucose (P < 0.01; r = 0.373), HOMA-IR (P < 0.01; r = 0.306; Figure 1c), HbA1c (P < 0.01; r = 0.415; Figure 1d) and TG (P < 0.01; r = 0.339) correlates inversely with FASN expression.


Inverse relation between FASN expression in human adipose tissue and the insulin resistance level.

Mayas MD, Ortega FJ, Macías-González M, Bernal R, Gómez-Huelgas R, Fernández-Real JM, Tinahones FJ - Nutr Metab (Lond) (2010)

Linear relationship between FASN expression and adiponectin (a), BMI (b), HOMA-IR (c) and HbA1c (d). Linear relationship was determined by Pearson's correlation coefficient test. 95% confidence interval.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC2820025&req=5

Figure 1: Linear relationship between FASN expression and adiponectin (a), BMI (b), HOMA-IR (c) and HbA1c (d). Linear relationship was determined by Pearson's correlation coefficient test. 95% confidence interval.
Mentions: The correlation between FASN expression and the different parameters that are associated with diabetes and obesity have shown the following results: there is a positive correlation of FASN expression with levels of adiponectin (P < 0.05; r = 0.265; Figure 1a) and HDL-c (P < 0.05; r = 0.276). BMI (P < 0.01; r = 0.383; Figure 1b), W-H (P < 0.05; r = 0.274), glucose (P < 0.01; r = 0.373), HOMA-IR (P < 0.01; r = 0.306; Figure 1c), HbA1c (P < 0.01; r = 0.415; Figure 1d) and TG (P < 0.01; r = 0.339) correlates inversely with FASN expression.

Bottom Line: The study included eighty-seven patients which were classified according to their BMI and to their glycaemia levels in order to study FASN and PPARgamma gene expression levels, anthropometric and biochemical variables.The correlation of the enzyme with these parameters is inversely proportional.On the other hand, PPARgamma is not related to carbohydrate metabolism.

View Article: PubMed Central - HTML - PubMed

Affiliation: Servicio de Endocrinología y Nutrición, Hospital Clínico Universitario Virgen de Victoria de Málaga, España.

ABSTRACT

Background: Adipose tissue is a key regulator of energy balance playing an active role in lipid storage and may be a dynamic buffer to control fatty acid flux. Just like PPARgamma, fatty acid synthesis enzymes such as FASN have been implicated in almost all aspects of human metabolic alterations such as obesity, insulin resistance or dyslipemia. The aim of this work is to investigate how FASN and PPARgamma expression in human adipose tissue is related to carbohydrate metabolism dysfunction and obesity.

Methods: The study included eighty-seven patients which were classified according to their BMI and to their glycaemia levels in order to study FASN and PPARgamma gene expression levels, anthropometric and biochemical variables.

Results: The main result of this work is the close relation between FASN expression level and the factors that lead to hyperglycemic state (increased values of glucose levels, HOMA-IR, HbA1c, BMI and triglycerides). The correlation of the enzyme with these parameters is inversely proportional. On the other hand, PPARgamma is not related to carbohydrate metabolism.

Conclusions: We can demonstrate that FASN expression is a good candidate to study the pathophysiology of type II diabetes and obesity in humans.

No MeSH data available.


Related in: MedlinePlus