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Relationship between morphological features and kinetic patterns of enhancement of the dynamic breast magnetic resonance imaging and clinico-pathological and biological factors in invasive breast cancer.

Fernández-Guinea O, Andicoechea A, González LO, González-Reyes S, Merino AM, Hernández LC, López-Muñiz A, García-Pravia P, Vizoso FJ - BMC Cancer (2010)

Bottom Line: However, there was a significant and positive association between the mitotic index and the peak of maximum intensity (p = 0.036).Peritumor inflammation was significantly associated with washout curve type III (p = 0.042).Variations in the early phase of dynamic MRI seem to be associated with parameters indicatives of tumor aggressiveness in breast cancer.

View Article: PubMed Central - HTML - PubMed

Affiliation: Unidad de Investigación, Hospital de Jove, Gijón-Spain.

ABSTRACT

Background: To investigate the relationship between the magnetic resonance imaging (MRI) features of breast cancer and its clinicopathological and biological factors.

Methods: Dynamic MRI parameters of 68 invasive breast carcinomas were investigated. We also analyzed microvessel density (MVD), estrogen and progesterone receptor status, and expression of p53, HER2, ki67, VEGFR-1 and 2.

Results: Homogeneous enhancement was significantly associated with smaller tumor size (T1: < 2 cm) (p = 0.015). Tumors with irregular or spiculated margins had a significantly higher MVD than tumors with smooth margins (p = 0.038). Tumors showing a maximum enhancement peak at two minutes, or longer, after injecting the contrast, had a significantly higher MVD count than those which reached this point sooner (p = 0.012). The percentage of tumors with vascular invasion or high mitotic index was significantly higher among those showing a low percentage (150%) of enhancement rate (p = 0.016 and p = 0.03, respectively). However, there was a significant and positive association between the mitotic index and the peak of maximum intensity (p = 0.036). Peritumor inflammation was significantly associated with washout curve type III (p = 0.042).

Conclusions: Variations in the early phase of dynamic MRI seem to be associated with parameters indicatives of tumor aggressiveness in breast cancer.

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Breast MR image acquired in a 50-years-old patient with a palpable mass in the right inferior outer quadrant. The axial postcontrast subtracted image (9.9/4.2; flip angle, 10°) depicts a lesion with spiculated margin of mass (arrow). The time-signal intensity curve of this shows a type III time course with a peak of maximal enhancement after two min. (A). Immunohistochemical staining of CD34 in the same tumor showing a high microvessel density. 100×. (B). Breast MR image acquired in a 63-years-old patient with a palpable mass in the left upper inner quadrant. The axial postcontrast subtracted image (9.9/4.2; flip angle, 10°) depicts a lesion with smooth margin of mass (arrow). The time-signal intensity curve of this shows a type III time course with a peak of maximal enhance before 2 min (C). Immunohistochemical staining of CD34 in the same tumor showing a low microvessel density. 100×. (D).
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Figure 1: Breast MR image acquired in a 50-years-old patient with a palpable mass in the right inferior outer quadrant. The axial postcontrast subtracted image (9.9/4.2; flip angle, 10°) depicts a lesion with spiculated margin of mass (arrow). The time-signal intensity curve of this shows a type III time course with a peak of maximal enhancement after two min. (A). Immunohistochemical staining of CD34 in the same tumor showing a high microvessel density. 100×. (B). Breast MR image acquired in a 63-years-old patient with a palpable mass in the left upper inner quadrant. The axial postcontrast subtracted image (9.9/4.2; flip angle, 10°) depicts a lesion with smooth margin of mass (arrow). The time-signal intensity curve of this shows a type III time course with a peak of maximal enhance before 2 min (C). Immunohistochemical staining of CD34 in the same tumor showing a low microvessel density. 100×. (D).

Mentions: Table 2 shows the relationship between morphological features, kinetic patterns of enhancement and the count of intratumoral microvessel density (MVD), by using immunostaining with anti-CD34. Tumors with irregular of spiculated mass margin had a significant higher MVD than tumors with smooth margin (p = 0.038). Likewise, we found that tumors showing a maximum enhancement peak at two minutes or longer, had a significant higher MVD count than those ones that reached this maximum point before two minutes (p = 0.012). Figure 1 shows representative examples of these associations.


Relationship between morphological features and kinetic patterns of enhancement of the dynamic breast magnetic resonance imaging and clinico-pathological and biological factors in invasive breast cancer.

Fernández-Guinea O, Andicoechea A, González LO, González-Reyes S, Merino AM, Hernández LC, López-Muñiz A, García-Pravia P, Vizoso FJ - BMC Cancer (2010)

Breast MR image acquired in a 50-years-old patient with a palpable mass in the right inferior outer quadrant. The axial postcontrast subtracted image (9.9/4.2; flip angle, 10°) depicts a lesion with spiculated margin of mass (arrow). The time-signal intensity curve of this shows a type III time course with a peak of maximal enhancement after two min. (A). Immunohistochemical staining of CD34 in the same tumor showing a high microvessel density. 100×. (B). Breast MR image acquired in a 63-years-old patient with a palpable mass in the left upper inner quadrant. The axial postcontrast subtracted image (9.9/4.2; flip angle, 10°) depicts a lesion with smooth margin of mass (arrow). The time-signal intensity curve of this shows a type III time course with a peak of maximal enhance before 2 min (C). Immunohistochemical staining of CD34 in the same tumor showing a low microvessel density. 100×. (D).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC2819997&req=5

Figure 1: Breast MR image acquired in a 50-years-old patient with a palpable mass in the right inferior outer quadrant. The axial postcontrast subtracted image (9.9/4.2; flip angle, 10°) depicts a lesion with spiculated margin of mass (arrow). The time-signal intensity curve of this shows a type III time course with a peak of maximal enhancement after two min. (A). Immunohistochemical staining of CD34 in the same tumor showing a high microvessel density. 100×. (B). Breast MR image acquired in a 63-years-old patient with a palpable mass in the left upper inner quadrant. The axial postcontrast subtracted image (9.9/4.2; flip angle, 10°) depicts a lesion with smooth margin of mass (arrow). The time-signal intensity curve of this shows a type III time course with a peak of maximal enhance before 2 min (C). Immunohistochemical staining of CD34 in the same tumor showing a low microvessel density. 100×. (D).
Mentions: Table 2 shows the relationship between morphological features, kinetic patterns of enhancement and the count of intratumoral microvessel density (MVD), by using immunostaining with anti-CD34. Tumors with irregular of spiculated mass margin had a significant higher MVD than tumors with smooth margin (p = 0.038). Likewise, we found that tumors showing a maximum enhancement peak at two minutes or longer, had a significant higher MVD count than those ones that reached this maximum point before two minutes (p = 0.012). Figure 1 shows representative examples of these associations.

Bottom Line: However, there was a significant and positive association between the mitotic index and the peak of maximum intensity (p = 0.036).Peritumor inflammation was significantly associated with washout curve type III (p = 0.042).Variations in the early phase of dynamic MRI seem to be associated with parameters indicatives of tumor aggressiveness in breast cancer.

View Article: PubMed Central - HTML - PubMed

Affiliation: Unidad de Investigación, Hospital de Jove, Gijón-Spain.

ABSTRACT

Background: To investigate the relationship between the magnetic resonance imaging (MRI) features of breast cancer and its clinicopathological and biological factors.

Methods: Dynamic MRI parameters of 68 invasive breast carcinomas were investigated. We also analyzed microvessel density (MVD), estrogen and progesterone receptor status, and expression of p53, HER2, ki67, VEGFR-1 and 2.

Results: Homogeneous enhancement was significantly associated with smaller tumor size (T1: < 2 cm) (p = 0.015). Tumors with irregular or spiculated margins had a significantly higher MVD than tumors with smooth margins (p = 0.038). Tumors showing a maximum enhancement peak at two minutes, or longer, after injecting the contrast, had a significantly higher MVD count than those which reached this point sooner (p = 0.012). The percentage of tumors with vascular invasion or high mitotic index was significantly higher among those showing a low percentage (150%) of enhancement rate (p = 0.016 and p = 0.03, respectively). However, there was a significant and positive association between the mitotic index and the peak of maximum intensity (p = 0.036). Peritumor inflammation was significantly associated with washout curve type III (p = 0.042).

Conclusions: Variations in the early phase of dynamic MRI seem to be associated with parameters indicatives of tumor aggressiveness in breast cancer.

Show MeSH
Related in: MedlinePlus