Limits...
Nanofunctionalized zirconia and barium sulfate particles as bone cement additives.

Gillani R, Ercan B, Qiao A, Webster TJ - Int J Nanomedicine (2010)

Bottom Line: Results demonstrated that in vitro osteoblast (bone-forming cell) densities were greater on bone cements containing BaSO(4) ceramic particles after four hours compared to control unmodified bone cements.Osteoblast densities were also greater on bone cements containing all of the ceramic particles after 24 hours compared to unmodified bone cements, particularly those bone cements containing nanofunctionalized ceramic particles.Bone cements containing ceramic particles demonstrated significantly altered mechanical properties; specifically, under tensile loading, plain bone cements and bone cements containing unfunctionalized ceramic particles exhibited brittle failure modes whereas bone cements containing nanofunctionalized ceramic particles exhibited plastic failure modes.

View Article: PubMed Central - PubMed

Affiliation: Division of Engineering and Department of Orthopaedics, Brown University, 184 Hope Street, Providence, RI 02912, USA.

ABSTRACT
Zirconia (ZrO(2)) and barium sulfate (BaSO(4)) particles were introduced into a methyl methacrylate monomer (MMA) solution with polymethyl methacrylate (PMMA) beads during polymerization to develop the following novel bone cements: bone cements with unfunctionalized ZrO(2) micron particles, bone cements with unfunctionalized ZrO(2) nanoparticles, bone cements with ZrO(2) nanoparticles functionalized with 3-(trimethoxysilyl)propyl methacrylate (TMS), bone cements with unfunctionalized BaSO(4) micron particles, bone cements with unfunctionalized BaSO(4) nanoparticles, and bone cements with BaSO(4) nanoparticles functionalized with TMS. Results demonstrated that in vitro osteoblast (bone-forming cell) densities were greater on bone cements containing BaSO(4) ceramic particles after four hours compared to control unmodified bone cements. Osteoblast densities were also greater on bone cements containing all of the ceramic particles after 24 hours compared to unmodified bone cements, particularly those bone cements containing nanofunctionalized ceramic particles. Bone cements containing ceramic particles demonstrated significantly altered mechanical properties; specifically, under tensile loading, plain bone cements and bone cements containing unfunctionalized ceramic particles exhibited brittle failure modes whereas bone cements containing nanofunctionalized ceramic particles exhibited plastic failure modes. Finally, all bone cements containing ceramic particles possessed greater radio-opacity than unmodified bone cements. In summary, the results of this study demonstrated a positive impact on the properties of traditional bone cements for orthopedic applications with the addition of unfunctionalized and TMS functionalized ceramic nanoparticles.

Show MeSH

Related in: MedlinePlus

Representative tensile stress-strain curves for various bone cements. One representative of three trials is shown for each bone cement. Bone cements tested included: Plain, ZM (containing micron particulate ZrO2), ZN (containing unfunctionalized ZrO2 nano-particles), ZNFT (containing functionalized ZrO2 nano-particles), BM (containing micron particulate BaSO4), BN (containing unfunctionalized BaSO4 nano-particles), and BNFT (containing functionalized BaSO4 nano-particles). A) All bone cements, B) Bone cements containing ZrO2 particles, and C) Bone cements containing BaSO4 particles.
© Copyright Policy
Related In: Results  -  Collection


getmorefigures.php?uid=PMC2819907&req=5

f6-ijn-5-001: Representative tensile stress-strain curves for various bone cements. One representative of three trials is shown for each bone cement. Bone cements tested included: Plain, ZM (containing micron particulate ZrO2), ZN (containing unfunctionalized ZrO2 nano-particles), ZNFT (containing functionalized ZrO2 nano-particles), BM (containing micron particulate BaSO4), BN (containing unfunctionalized BaSO4 nano-particles), and BNFT (containing functionalized BaSO4 nano-particles). A) All bone cements, B) Bone cements containing ZrO2 particles, and C) Bone cements containing BaSO4 particles.

Mentions: Most importantly, the results of this study showed a clear difference between the failure modes for the various bone cements fabricated in this study (Figures 6 and 7). Plain bone cements as well as bone cements containing unfunctionalized ceramic micron and nanoparticles had failure modes characteristic of brittle fracture, while bone cements containing functionalized ceramic nanoparticles had failure modes that were less brittle and had a clear plastic deformation region.


Nanofunctionalized zirconia and barium sulfate particles as bone cement additives.

Gillani R, Ercan B, Qiao A, Webster TJ - Int J Nanomedicine (2010)

Representative tensile stress-strain curves for various bone cements. One representative of three trials is shown for each bone cement. Bone cements tested included: Plain, ZM (containing micron particulate ZrO2), ZN (containing unfunctionalized ZrO2 nano-particles), ZNFT (containing functionalized ZrO2 nano-particles), BM (containing micron particulate BaSO4), BN (containing unfunctionalized BaSO4 nano-particles), and BNFT (containing functionalized BaSO4 nano-particles). A) All bone cements, B) Bone cements containing ZrO2 particles, and C) Bone cements containing BaSO4 particles.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC2819907&req=5

f6-ijn-5-001: Representative tensile stress-strain curves for various bone cements. One representative of three trials is shown for each bone cement. Bone cements tested included: Plain, ZM (containing micron particulate ZrO2), ZN (containing unfunctionalized ZrO2 nano-particles), ZNFT (containing functionalized ZrO2 nano-particles), BM (containing micron particulate BaSO4), BN (containing unfunctionalized BaSO4 nano-particles), and BNFT (containing functionalized BaSO4 nano-particles). A) All bone cements, B) Bone cements containing ZrO2 particles, and C) Bone cements containing BaSO4 particles.
Mentions: Most importantly, the results of this study showed a clear difference between the failure modes for the various bone cements fabricated in this study (Figures 6 and 7). Plain bone cements as well as bone cements containing unfunctionalized ceramic micron and nanoparticles had failure modes characteristic of brittle fracture, while bone cements containing functionalized ceramic nanoparticles had failure modes that were less brittle and had a clear plastic deformation region.

Bottom Line: Results demonstrated that in vitro osteoblast (bone-forming cell) densities were greater on bone cements containing BaSO(4) ceramic particles after four hours compared to control unmodified bone cements.Osteoblast densities were also greater on bone cements containing all of the ceramic particles after 24 hours compared to unmodified bone cements, particularly those bone cements containing nanofunctionalized ceramic particles.Bone cements containing ceramic particles demonstrated significantly altered mechanical properties; specifically, under tensile loading, plain bone cements and bone cements containing unfunctionalized ceramic particles exhibited brittle failure modes whereas bone cements containing nanofunctionalized ceramic particles exhibited plastic failure modes.

View Article: PubMed Central - PubMed

Affiliation: Division of Engineering and Department of Orthopaedics, Brown University, 184 Hope Street, Providence, RI 02912, USA.

ABSTRACT
Zirconia (ZrO(2)) and barium sulfate (BaSO(4)) particles were introduced into a methyl methacrylate monomer (MMA) solution with polymethyl methacrylate (PMMA) beads during polymerization to develop the following novel bone cements: bone cements with unfunctionalized ZrO(2) micron particles, bone cements with unfunctionalized ZrO(2) nanoparticles, bone cements with ZrO(2) nanoparticles functionalized with 3-(trimethoxysilyl)propyl methacrylate (TMS), bone cements with unfunctionalized BaSO(4) micron particles, bone cements with unfunctionalized BaSO(4) nanoparticles, and bone cements with BaSO(4) nanoparticles functionalized with TMS. Results demonstrated that in vitro osteoblast (bone-forming cell) densities were greater on bone cements containing BaSO(4) ceramic particles after four hours compared to control unmodified bone cements. Osteoblast densities were also greater on bone cements containing all of the ceramic particles after 24 hours compared to unmodified bone cements, particularly those bone cements containing nanofunctionalized ceramic particles. Bone cements containing ceramic particles demonstrated significantly altered mechanical properties; specifically, under tensile loading, plain bone cements and bone cements containing unfunctionalized ceramic particles exhibited brittle failure modes whereas bone cements containing nanofunctionalized ceramic particles exhibited plastic failure modes. Finally, all bone cements containing ceramic particles possessed greater radio-opacity than unmodified bone cements. In summary, the results of this study demonstrated a positive impact on the properties of traditional bone cements for orthopedic applications with the addition of unfunctionalized and TMS functionalized ceramic nanoparticles.

Show MeSH
Related in: MedlinePlus