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Nanofunctionalized zirconia and barium sulfate particles as bone cement additives.

Gillani R, Ercan B, Qiao A, Webster TJ - Int J Nanomedicine (2010)

Bottom Line: Results demonstrated that in vitro osteoblast (bone-forming cell) densities were greater on bone cements containing BaSO(4) ceramic particles after four hours compared to control unmodified bone cements.Osteoblast densities were also greater on bone cements containing all of the ceramic particles after 24 hours compared to unmodified bone cements, particularly those bone cements containing nanofunctionalized ceramic particles.Bone cements containing ceramic particles demonstrated significantly altered mechanical properties; specifically, under tensile loading, plain bone cements and bone cements containing unfunctionalized ceramic particles exhibited brittle failure modes whereas bone cements containing nanofunctionalized ceramic particles exhibited plastic failure modes.

View Article: PubMed Central - PubMed

Affiliation: Division of Engineering and Department of Orthopaedics, Brown University, 184 Hope Street, Providence, RI 02912, USA.

ABSTRACT
Zirconia (ZrO(2)) and barium sulfate (BaSO(4)) particles were introduced into a methyl methacrylate monomer (MMA) solution with polymethyl methacrylate (PMMA) beads during polymerization to develop the following novel bone cements: bone cements with unfunctionalized ZrO(2) micron particles, bone cements with unfunctionalized ZrO(2) nanoparticles, bone cements with ZrO(2) nanoparticles functionalized with 3-(trimethoxysilyl)propyl methacrylate (TMS), bone cements with unfunctionalized BaSO(4) micron particles, bone cements with unfunctionalized BaSO(4) nanoparticles, and bone cements with BaSO(4) nanoparticles functionalized with TMS. Results demonstrated that in vitro osteoblast (bone-forming cell) densities were greater on bone cements containing BaSO(4) ceramic particles after four hours compared to control unmodified bone cements. Osteoblast densities were also greater on bone cements containing all of the ceramic particles after 24 hours compared to unmodified bone cements, particularly those bone cements containing nanofunctionalized ceramic particles. Bone cements containing ceramic particles demonstrated significantly altered mechanical properties; specifically, under tensile loading, plain bone cements and bone cements containing unfunctionalized ceramic particles exhibited brittle failure modes whereas bone cements containing nanofunctionalized ceramic particles exhibited plastic failure modes. Finally, all bone cements containing ceramic particles possessed greater radio-opacity than unmodified bone cements. In summary, the results of this study demonstrated a positive impact on the properties of traditional bone cements for orthopedic applications with the addition of unfunctionalized and TMS functionalized ceramic nanoparticles.

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Fluorescence microscopy images (magnification = 10X) of osteoblasts after 24 hours of proliferation on different bone cements: A) Plain, B) ZM (containing micron particulate ZrO2), C) ZN (containing unfunctionalized ZrO2 nano-particles), D) ZNFT (containing ZrO2 nano-particles functionalized with TMS, E) BM (containing micron particulate BaSO4), F) BN (containing unfunctionalized BaSO4 nano-additives), and G) BNFT (containing BaSO4 nano-additives functionalized with TMS).
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f5-ijn-5-001: Fluorescence microscopy images (magnification = 10X) of osteoblasts after 24 hours of proliferation on different bone cements: A) Plain, B) ZM (containing micron particulate ZrO2), C) ZN (containing unfunctionalized ZrO2 nano-particles), D) ZNFT (containing ZrO2 nano-particles functionalized with TMS, E) BM (containing micron particulate BaSO4), F) BN (containing unfunctionalized BaSO4 nano-additives), and G) BNFT (containing BaSO4 nano-additives functionalized with TMS).

Mentions: Fluorescence microscopy images of osteoblasts after the four- and 24-hour incubation periods, respectively, further demonstrated such trends (Figures 4 and 5). Lastly, the addition of ceramic particles and their subsequent nanoscaling and chemical functionalization with the silane-coupling agent TMS, was shown to have a positive impact on osteoblast densities.


Nanofunctionalized zirconia and barium sulfate particles as bone cement additives.

Gillani R, Ercan B, Qiao A, Webster TJ - Int J Nanomedicine (2010)

Fluorescence microscopy images (magnification = 10X) of osteoblasts after 24 hours of proliferation on different bone cements: A) Plain, B) ZM (containing micron particulate ZrO2), C) ZN (containing unfunctionalized ZrO2 nano-particles), D) ZNFT (containing ZrO2 nano-particles functionalized with TMS, E) BM (containing micron particulate BaSO4), F) BN (containing unfunctionalized BaSO4 nano-additives), and G) BNFT (containing BaSO4 nano-additives functionalized with TMS).
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC2819907&req=5

f5-ijn-5-001: Fluorescence microscopy images (magnification = 10X) of osteoblasts after 24 hours of proliferation on different bone cements: A) Plain, B) ZM (containing micron particulate ZrO2), C) ZN (containing unfunctionalized ZrO2 nano-particles), D) ZNFT (containing ZrO2 nano-particles functionalized with TMS, E) BM (containing micron particulate BaSO4), F) BN (containing unfunctionalized BaSO4 nano-additives), and G) BNFT (containing BaSO4 nano-additives functionalized with TMS).
Mentions: Fluorescence microscopy images of osteoblasts after the four- and 24-hour incubation periods, respectively, further demonstrated such trends (Figures 4 and 5). Lastly, the addition of ceramic particles and their subsequent nanoscaling and chemical functionalization with the silane-coupling agent TMS, was shown to have a positive impact on osteoblast densities.

Bottom Line: Results demonstrated that in vitro osteoblast (bone-forming cell) densities were greater on bone cements containing BaSO(4) ceramic particles after four hours compared to control unmodified bone cements.Osteoblast densities were also greater on bone cements containing all of the ceramic particles after 24 hours compared to unmodified bone cements, particularly those bone cements containing nanofunctionalized ceramic particles.Bone cements containing ceramic particles demonstrated significantly altered mechanical properties; specifically, under tensile loading, plain bone cements and bone cements containing unfunctionalized ceramic particles exhibited brittle failure modes whereas bone cements containing nanofunctionalized ceramic particles exhibited plastic failure modes.

View Article: PubMed Central - PubMed

Affiliation: Division of Engineering and Department of Orthopaedics, Brown University, 184 Hope Street, Providence, RI 02912, USA.

ABSTRACT
Zirconia (ZrO(2)) and barium sulfate (BaSO(4)) particles were introduced into a methyl methacrylate monomer (MMA) solution with polymethyl methacrylate (PMMA) beads during polymerization to develop the following novel bone cements: bone cements with unfunctionalized ZrO(2) micron particles, bone cements with unfunctionalized ZrO(2) nanoparticles, bone cements with ZrO(2) nanoparticles functionalized with 3-(trimethoxysilyl)propyl methacrylate (TMS), bone cements with unfunctionalized BaSO(4) micron particles, bone cements with unfunctionalized BaSO(4) nanoparticles, and bone cements with BaSO(4) nanoparticles functionalized with TMS. Results demonstrated that in vitro osteoblast (bone-forming cell) densities were greater on bone cements containing BaSO(4) ceramic particles after four hours compared to control unmodified bone cements. Osteoblast densities were also greater on bone cements containing all of the ceramic particles after 24 hours compared to unmodified bone cements, particularly those bone cements containing nanofunctionalized ceramic particles. Bone cements containing ceramic particles demonstrated significantly altered mechanical properties; specifically, under tensile loading, plain bone cements and bone cements containing unfunctionalized ceramic particles exhibited brittle failure modes whereas bone cements containing nanofunctionalized ceramic particles exhibited plastic failure modes. Finally, all bone cements containing ceramic particles possessed greater radio-opacity than unmodified bone cements. In summary, the results of this study demonstrated a positive impact on the properties of traditional bone cements for orthopedic applications with the addition of unfunctionalized and TMS functionalized ceramic nanoparticles.

Show MeSH
Related in: MedlinePlus