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Hantavirus infection in the Republic of Georgia.

Kuchuloria T, Clark DV, Hepburn MJ, Tsertsvadze T, Pimentel G, Imnadze P - Emerging Infect. Dis. (2009)

Bottom Line: We describe a laboratory-confirmed case of hantavirus infection in the Republic of Georgia.Limited information is available about hantavirus infections in the Caucasus, although the infection has been reported throughout Europe and Russia.Increasing awareness and active disease surveillance contribute to our improved understanding of the geographic range of this pathogen.

View Article: PubMed Central - PubMed

Affiliation: Technology Management Company, Tbilisi, Georgia. drkuchuloria@yahoo.com

ABSTRACT
We describe a laboratory-confirmed case of hantavirus infection in the Republic of Georgia. Limited information is available about hantavirus infections in the Caucasus, although the infection has been reported throughout Europe and Russia. Increasing awareness and active disease surveillance contribute to our improved understanding of the geographic range of this pathogen.

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Related in: MedlinePlus

Acute tubular necrosis in a renal biopsy specimen of the patient. Magnification ×40.
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Figure 1: Acute tubular necrosis in a renal biopsy specimen of the patient. Magnification ×40.

Mentions: Serum samples were tested for antibodies against a panel of pathogens, including Salmonella enterica serovar Typhi, S. paratyphi A and B, Epstein-Barr virus, Brucella spp., Coxiella burnetti, hantavirus, Rickettsia (spotted fever and scrub typhus groups), West Nile virus, tick-borne encephalitis virus, and Leptospira spp. All serologic test results were negative except for the test result for hantavirus. To corroborate hospital laboratory diagnostics, serum samples were also tested in a private laboratory in Germany by using Western blot assay (recomBlot Bunyavirus immunoglobulin [Ig]G/IgM; Mikrogen, Neuried, Germany) and immunofluorescence antibody (IFA) assay (Progen, Heidelberg, Germany). Results from the Western blot assay were negative for Puumala IgG and positive for Hantaan IgG and Dobrava IgM. The IFA result for Hantaan antibodies was positive at a reciprocal titer >2,048. The Naval Medical Research Unit No. 3 in Egypt conducted a hantavirus IgM ELISA (Focus Diagnostics, Cypress, CA, USA) on paired serum samples (acute-phase sample positive:negative ratio = 8.42; convalescent phase = 7.815, cut-off 1.10). Results of blood and Leptospira spp. cultures were negative. A renal biospy specimen obtained 10 days after disease onset showed acute tubular necrosis with mild-grade arteriolosclerosis (Figure).


Hantavirus infection in the Republic of Georgia.

Kuchuloria T, Clark DV, Hepburn MJ, Tsertsvadze T, Pimentel G, Imnadze P - Emerging Infect. Dis. (2009)

Acute tubular necrosis in a renal biopsy specimen of the patient. Magnification ×40.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC2819886&req=5

Figure 1: Acute tubular necrosis in a renal biopsy specimen of the patient. Magnification ×40.
Mentions: Serum samples were tested for antibodies against a panel of pathogens, including Salmonella enterica serovar Typhi, S. paratyphi A and B, Epstein-Barr virus, Brucella spp., Coxiella burnetti, hantavirus, Rickettsia (spotted fever and scrub typhus groups), West Nile virus, tick-borne encephalitis virus, and Leptospira spp. All serologic test results were negative except for the test result for hantavirus. To corroborate hospital laboratory diagnostics, serum samples were also tested in a private laboratory in Germany by using Western blot assay (recomBlot Bunyavirus immunoglobulin [Ig]G/IgM; Mikrogen, Neuried, Germany) and immunofluorescence antibody (IFA) assay (Progen, Heidelberg, Germany). Results from the Western blot assay were negative for Puumala IgG and positive for Hantaan IgG and Dobrava IgM. The IFA result for Hantaan antibodies was positive at a reciprocal titer >2,048. The Naval Medical Research Unit No. 3 in Egypt conducted a hantavirus IgM ELISA (Focus Diagnostics, Cypress, CA, USA) on paired serum samples (acute-phase sample positive:negative ratio = 8.42; convalescent phase = 7.815, cut-off 1.10). Results of blood and Leptospira spp. cultures were negative. A renal biospy specimen obtained 10 days after disease onset showed acute tubular necrosis with mild-grade arteriolosclerosis (Figure).

Bottom Line: We describe a laboratory-confirmed case of hantavirus infection in the Republic of Georgia.Limited information is available about hantavirus infections in the Caucasus, although the infection has been reported throughout Europe and Russia.Increasing awareness and active disease surveillance contribute to our improved understanding of the geographic range of this pathogen.

View Article: PubMed Central - PubMed

Affiliation: Technology Management Company, Tbilisi, Georgia. drkuchuloria@yahoo.com

ABSTRACT
We describe a laboratory-confirmed case of hantavirus infection in the Republic of Georgia. Limited information is available about hantavirus infections in the Caucasus, although the infection has been reported throughout Europe and Russia. Increasing awareness and active disease surveillance contribute to our improved understanding of the geographic range of this pathogen.

Show MeSH
Related in: MedlinePlus