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Genetic characterization of foot-and-mouth disease viruses, Ethiopia, 1981-2007.

Ayelet G, Mahapatra M, Gelaye E, Egziabher BG, Rufeal T, Sahle M, Ferris NP, Wadsworth J, Hutchings GH, Knowles NJ - Emerging Infect. Dis. (2009)

Bottom Line: We detected 5 of the 7 FMDV serotypes (O, A, C, Southern African Territories [SAT] 1, and SAT 2).Serotype O predominated, followed by serotype A; type C was not recognized after 1983.In 2007, serotype SAT 1 was detected in Ethiopia and formed a new distinct topotype (IX), and serotype SAT 2 reappeared after an apparent gap of 16 years.

View Article: PubMed Central - PubMed

Affiliation: National Veterinary Institute, Debre Zeit, Ethiopia.

ABSTRACT
Foot-and-mouth disease (FMD) is endemic to sub-Saharan Africa. To further understand its complex epidemiology, which involves multiple virus serotypes and host species, we characterized the viruses recovered from FMD outbreaks in Ethiopia during 1981-2007. We detected 5 of the 7 FMDV serotypes (O, A, C, Southern African Territories [SAT] 1, and SAT 2). Serotype O predominated, followed by serotype A; type C was not recognized after 1983. Phylogenetic analysis of virus protein 1 sequences indicated emergence of a new topotype within serotype O, East Africa 4. In 2007, serotype SAT 1 was detected in Ethiopia and formed a new distinct topotype (IX), and serotype SAT 2 reappeared after an apparent gap of 16 years. The diversity of viruses highlights the role of this region as a reservoir for FMD virus, and their continuing emergence in Ethiopia will greatly affect spread and consequent control strategy of the disease on this continent.

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Related in: MedlinePlus

Midpoint-rooted neighbor-joining tree (based on the complete virus protein 1 coding sequence) showing the relationships between the foot-and-mouth disease virus serotype Southern African Territories (SAT) 1 isolates from Ethiopia and other contemporary and reference viruses. The 4 isolates from Ethiopia in 2007 are boxed. The year in parenthesis indicates the year of sample collection. Scale bar indicates substitutions per site. *Not a reference number assigned by the World Reference Laboratory for Foot-and-Mouth Disease, Pirbright, UK.
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Figure 4: Midpoint-rooted neighbor-joining tree (based on the complete virus protein 1 coding sequence) showing the relationships between the foot-and-mouth disease virus serotype Southern African Territories (SAT) 1 isolates from Ethiopia and other contemporary and reference viruses. The 4 isolates from Ethiopia in 2007 are boxed. The year in parenthesis indicates the year of sample collection. Scale bar indicates substitutions per site. *Not a reference number assigned by the World Reference Laboratory for Foot-and-Mouth Disease, Pirbright, UK.

Mentions: Genetic characterization of the newly identified SAT 1 isolates from Ethiopia indicates that they are all closely related but distinct from all other SAT 1 viruses from East Africa examined in this study (Figure 4). They were most closely related to viruses from Niger and Nigeria during 1975–1976 (topotype V) (24) but were different enough (SAT1/ETH/4/2007 vs. SAT1/NIG/11/75, 23% nt difference) to be classified as a new topotype, which we named topotype IX.


Genetic characterization of foot-and-mouth disease viruses, Ethiopia, 1981-2007.

Ayelet G, Mahapatra M, Gelaye E, Egziabher BG, Rufeal T, Sahle M, Ferris NP, Wadsworth J, Hutchings GH, Knowles NJ - Emerging Infect. Dis. (2009)

Midpoint-rooted neighbor-joining tree (based on the complete virus protein 1 coding sequence) showing the relationships between the foot-and-mouth disease virus serotype Southern African Territories (SAT) 1 isolates from Ethiopia and other contemporary and reference viruses. The 4 isolates from Ethiopia in 2007 are boxed. The year in parenthesis indicates the year of sample collection. Scale bar indicates substitutions per site. *Not a reference number assigned by the World Reference Laboratory for Foot-and-Mouth Disease, Pirbright, UK.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC2819860&req=5

Figure 4: Midpoint-rooted neighbor-joining tree (based on the complete virus protein 1 coding sequence) showing the relationships between the foot-and-mouth disease virus serotype Southern African Territories (SAT) 1 isolates from Ethiopia and other contemporary and reference viruses. The 4 isolates from Ethiopia in 2007 are boxed. The year in parenthesis indicates the year of sample collection. Scale bar indicates substitutions per site. *Not a reference number assigned by the World Reference Laboratory for Foot-and-Mouth Disease, Pirbright, UK.
Mentions: Genetic characterization of the newly identified SAT 1 isolates from Ethiopia indicates that they are all closely related but distinct from all other SAT 1 viruses from East Africa examined in this study (Figure 4). They were most closely related to viruses from Niger and Nigeria during 1975–1976 (topotype V) (24) but were different enough (SAT1/ETH/4/2007 vs. SAT1/NIG/11/75, 23% nt difference) to be classified as a new topotype, which we named topotype IX.

Bottom Line: We detected 5 of the 7 FMDV serotypes (O, A, C, Southern African Territories [SAT] 1, and SAT 2).Serotype O predominated, followed by serotype A; type C was not recognized after 1983.In 2007, serotype SAT 1 was detected in Ethiopia and formed a new distinct topotype (IX), and serotype SAT 2 reappeared after an apparent gap of 16 years.

View Article: PubMed Central - PubMed

Affiliation: National Veterinary Institute, Debre Zeit, Ethiopia.

ABSTRACT
Foot-and-mouth disease (FMD) is endemic to sub-Saharan Africa. To further understand its complex epidemiology, which involves multiple virus serotypes and host species, we characterized the viruses recovered from FMD outbreaks in Ethiopia during 1981-2007. We detected 5 of the 7 FMDV serotypes (O, A, C, Southern African Territories [SAT] 1, and SAT 2). Serotype O predominated, followed by serotype A; type C was not recognized after 1983. Phylogenetic analysis of virus protein 1 sequences indicated emergence of a new topotype within serotype O, East Africa 4. In 2007, serotype SAT 1 was detected in Ethiopia and formed a new distinct topotype (IX), and serotype SAT 2 reappeared after an apparent gap of 16 years. The diversity of viruses highlights the role of this region as a reservoir for FMD virus, and their continuing emergence in Ethiopia will greatly affect spread and consequent control strategy of the disease on this continent.

Show MeSH
Related in: MedlinePlus