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Advances in identifying beryllium sensitization and disease.

Middleton D, Kowalski P - Int J Environ Res Public Health (2010)

Bottom Line: Beryllium is a lightweight metal with unique qualities related to stiffness, corrosion resistance, and conductivity.Acute beryllium disease is a pulmonary irritant response to high exposure levels, whereas chronic beryllium disease (CBD) typically results from a hypersensitivity response to lower exposure levels.While there is no true "gold standard" for BeS, basic epidemiologic concepts have been used to advance our understanding of the different screening algorithms.

View Article: PubMed Central - PubMed

Affiliation: Division of Health Studies, Agency for Toxic Substances and Disease Registry, Atlanta, GA 30341, USA. dcm2@cdc.gov

ABSTRACT
Beryllium is a lightweight metal with unique qualities related to stiffness, corrosion resistance, and conductivity. While there are many useful applications, researchers in the 1930s and 1940s linked beryllium exposure to a progressive occupational lung disease. Acute beryllium disease is a pulmonary irritant response to high exposure levels, whereas chronic beryllium disease (CBD) typically results from a hypersensitivity response to lower exposure levels. A blood test, the beryllium lymphocyte proliferation test (BeLPT), was an important advance in identifying individuals who are sensitized to beryllium (BeS) and thus at risk for developing CBD. While there is no true "gold standard" for BeS, basic epidemiologic concepts have been used to advance our understanding of the different screening algorithms.

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Related in: MedlinePlus

One abnormal and one borderline provide sufficient evidence for beryllium sensitization.
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Related In: Results  -  Collection

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f2-ijerph-07-00115: One abnormal and one borderline provide sufficient evidence for beryllium sensitization.

Mentions: The individual tables for Figures 2 and 3 are not presented in this review, but are published elsewhere [17]. The overall characteristics for each algorithm/criteria are shown in Table 2.


Advances in identifying beryllium sensitization and disease.

Middleton D, Kowalski P - Int J Environ Res Public Health (2010)

One abnormal and one borderline provide sufficient evidence for beryllium sensitization.
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC2819779&req=5

f2-ijerph-07-00115: One abnormal and one borderline provide sufficient evidence for beryllium sensitization.
Mentions: The individual tables for Figures 2 and 3 are not presented in this review, but are published elsewhere [17]. The overall characteristics for each algorithm/criteria are shown in Table 2.

Bottom Line: Beryllium is a lightweight metal with unique qualities related to stiffness, corrosion resistance, and conductivity.Acute beryllium disease is a pulmonary irritant response to high exposure levels, whereas chronic beryllium disease (CBD) typically results from a hypersensitivity response to lower exposure levels.While there is no true "gold standard" for BeS, basic epidemiologic concepts have been used to advance our understanding of the different screening algorithms.

View Article: PubMed Central - PubMed

Affiliation: Division of Health Studies, Agency for Toxic Substances and Disease Registry, Atlanta, GA 30341, USA. dcm2@cdc.gov

ABSTRACT
Beryllium is a lightweight metal with unique qualities related to stiffness, corrosion resistance, and conductivity. While there are many useful applications, researchers in the 1930s and 1940s linked beryllium exposure to a progressive occupational lung disease. Acute beryllium disease is a pulmonary irritant response to high exposure levels, whereas chronic beryllium disease (CBD) typically results from a hypersensitivity response to lower exposure levels. A blood test, the beryllium lymphocyte proliferation test (BeLPT), was an important advance in identifying individuals who are sensitized to beryllium (BeS) and thus at risk for developing CBD. While there is no true "gold standard" for BeS, basic epidemiologic concepts have been used to advance our understanding of the different screening algorithms.

Show MeSH
Related in: MedlinePlus