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Dose-related effects of MDMA on psychomotor function and mood before, during, and after a night of sleep loss.

Bosker WM, Kuypers KP, Conen S, Ramaekers JG - Psychopharmacology (Berl.) (2010)

Bottom Line: Results showed that sleep loss significantly impaired psychomotor function.MDMA generally did not affect performance but did improve rapid information processing at the highest dose in the morning after administration.It is concluded that sleep deprivation impairs psychomotor function and that stimulant effects of MDMA are not sufficient to compensate for this impairment.

View Article: PubMed Central - PubMed

Affiliation: Department of Neuropsychology and Psychopharmacology, Maastricht University, Maastricht, The Netherlands. Wendy.bosker@maastrichtuniversity.nl

ABSTRACT

Introduction: 3,4-methylenedioxymethamphetamine (MDMA) is known to improve psychomotor function and mood when measured during daytime. However, MDMA users tend to take this drug at dance parties while staying awake for prolonged periods of time.

Subjects and methods: This study was designed to assess dose-related residual effects of MDMA on psychomotor function and mood after a night without sleep. Sixteen recreational MDMA users received single doses of 25, 50, and 100 mg MDMA in a randomized, double-blind, placebo-controlled cross-over study.

Results: Results showed that sleep loss significantly impaired psychomotor function. MDMA generally did not affect performance but did improve rapid information processing at the highest dose in the morning after administration. In the evening, MDMA also increased subjective ratings of positive mood at every dose and subjective arousal at the highest dose. These subjective effects were no longer present after a night of sleep loss.

Discussion: It is concluded that sleep deprivation impairs psychomotor function and that stimulant effects of MDMA are not sufficient to compensate for this impairment.

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Related in: MedlinePlus

Mean (SE) score on profile of mood states positive mood scale in every treatment condition as a function of time after drug administration
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Fig4: Mean (SE) score on profile of mood states positive mood scale in every treatment condition as a function of time after drug administration

Mentions: ANOVA of the profile of mood states showed a significant interaction between MDMA and sleep loss on the arousal (F3,45 = 4.294, p = 0.010) and positive mood scale (F3,45 = 9.526, p = 0.000). Simple drug-placebo contrasts indicated that MDMA 100 mg increased arousal (p = 0.012) in the evening but not in the morning, as compared to placebo. Drug-placebo contrasts also showed that all MDMA doses (p < 0.046) increased positive mood in the evening after drug intake but not in the morning. Mean (SE) arousal and positive mood ratings during treatment are given in Figs. 3 and 4, respectively.Fig. 3


Dose-related effects of MDMA on psychomotor function and mood before, during, and after a night of sleep loss.

Bosker WM, Kuypers KP, Conen S, Ramaekers JG - Psychopharmacology (Berl.) (2010)

Mean (SE) score on profile of mood states positive mood scale in every treatment condition as a function of time after drug administration
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC2819659&req=5

Fig4: Mean (SE) score on profile of mood states positive mood scale in every treatment condition as a function of time after drug administration
Mentions: ANOVA of the profile of mood states showed a significant interaction between MDMA and sleep loss on the arousal (F3,45 = 4.294, p = 0.010) and positive mood scale (F3,45 = 9.526, p = 0.000). Simple drug-placebo contrasts indicated that MDMA 100 mg increased arousal (p = 0.012) in the evening but not in the morning, as compared to placebo. Drug-placebo contrasts also showed that all MDMA doses (p < 0.046) increased positive mood in the evening after drug intake but not in the morning. Mean (SE) arousal and positive mood ratings during treatment are given in Figs. 3 and 4, respectively.Fig. 3

Bottom Line: Results showed that sleep loss significantly impaired psychomotor function.MDMA generally did not affect performance but did improve rapid information processing at the highest dose in the morning after administration.It is concluded that sleep deprivation impairs psychomotor function and that stimulant effects of MDMA are not sufficient to compensate for this impairment.

View Article: PubMed Central - PubMed

Affiliation: Department of Neuropsychology and Psychopharmacology, Maastricht University, Maastricht, The Netherlands. Wendy.bosker@maastrichtuniversity.nl

ABSTRACT

Introduction: 3,4-methylenedioxymethamphetamine (MDMA) is known to improve psychomotor function and mood when measured during daytime. However, MDMA users tend to take this drug at dance parties while staying awake for prolonged periods of time.

Subjects and methods: This study was designed to assess dose-related residual effects of MDMA on psychomotor function and mood after a night without sleep. Sixteen recreational MDMA users received single doses of 25, 50, and 100 mg MDMA in a randomized, double-blind, placebo-controlled cross-over study.

Results: Results showed that sleep loss significantly impaired psychomotor function. MDMA generally did not affect performance but did improve rapid information processing at the highest dose in the morning after administration. In the evening, MDMA also increased subjective ratings of positive mood at every dose and subjective arousal at the highest dose. These subjective effects were no longer present after a night of sleep loss.

Discussion: It is concluded that sleep deprivation impairs psychomotor function and that stimulant effects of MDMA are not sufficient to compensate for this impairment.

Show MeSH
Related in: MedlinePlus