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Recurrent hemolytic uremic syndrome.

Lakshminarayana G, Rajesh R, Jojo A, Kurian G, Unni VN - Indian J Nephrol (2008)

Bottom Line: Diarrhea-associated (D+) HUS, usually seen in children, is a common variety of HUS.HUS that is not associated with diarrhea (D-) is caused by a heterogeneous group of disorders.We report here a case of recurrent HUS (D-) in an adult female with hypocomplementemia.

View Article: PubMed Central - PubMed

ABSTRACT
Hemolytic uremic syndrome (HUS) is an uncommon cause of acute renal failure. Diarrhea-associated (D+) HUS, usually seen in children, is a common variety of HUS. HUS that is not associated with diarrhea (D-) is caused by a heterogeneous group of disorders. We report here a case of recurrent HUS (D-) in an adult female with hypocomplementemia.

No MeSH data available.


Related in: MedlinePlus

Peripheral blood smear showing schistocytes, helmet cells and burr cells
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Figure 0001: Peripheral blood smear showing schistocytes, helmet cells and burr cells

Mentions: Investigations revealed Hb: 5.5 g/dL, platelets: 49,000/cu. mm, reticulocyte count: 10/dL, and a peripheral smear showed polychromasia, nucleated RBCs, helmet cells, schistocytes, and burr cells [Fig. 1] suggestive of microangiopathic hemolytic anemia. She had unconjugated hyperbilirubinemia with normal aspartate aminotransferase, alanine aminotransferase and alkaline phosphatase, and the lactate dehydrogenase (LDH) level was 7200 U/L. She was found to have severe renal failure (creatinine: 11.6 mg/dL) with 2+ proteinuria and microhematuria. PT/aPTT and fibrinogen were normal, blood and urine cultures were sterile; she had low serum C3 (Serum C3: 65 mg/dL, normal: 80–120 mg/dL) and normal C4 levels. Coomb's test was negative and antinuclear antibody as well as anti-ds DNA were negative. Bone marrow showed erythroid hyperplasia and; the ultrasound of the abdomen and pelvis was normal. The patient was diagnosed to have D – hemolytic uremic syndrome (D- HUS).


Recurrent hemolytic uremic syndrome.

Lakshminarayana G, Rajesh R, Jojo A, Kurian G, Unni VN - Indian J Nephrol (2008)

Peripheral blood smear showing schistocytes, helmet cells and burr cells
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC2813136&req=5

Figure 0001: Peripheral blood smear showing schistocytes, helmet cells and burr cells
Mentions: Investigations revealed Hb: 5.5 g/dL, platelets: 49,000/cu. mm, reticulocyte count: 10/dL, and a peripheral smear showed polychromasia, nucleated RBCs, helmet cells, schistocytes, and burr cells [Fig. 1] suggestive of microangiopathic hemolytic anemia. She had unconjugated hyperbilirubinemia with normal aspartate aminotransferase, alanine aminotransferase and alkaline phosphatase, and the lactate dehydrogenase (LDH) level was 7200 U/L. She was found to have severe renal failure (creatinine: 11.6 mg/dL) with 2+ proteinuria and microhematuria. PT/aPTT and fibrinogen were normal, blood and urine cultures were sterile; she had low serum C3 (Serum C3: 65 mg/dL, normal: 80–120 mg/dL) and normal C4 levels. Coomb's test was negative and antinuclear antibody as well as anti-ds DNA were negative. Bone marrow showed erythroid hyperplasia and; the ultrasound of the abdomen and pelvis was normal. The patient was diagnosed to have D – hemolytic uremic syndrome (D- HUS).

Bottom Line: Diarrhea-associated (D+) HUS, usually seen in children, is a common variety of HUS.HUS that is not associated with diarrhea (D-) is caused by a heterogeneous group of disorders.We report here a case of recurrent HUS (D-) in an adult female with hypocomplementemia.

View Article: PubMed Central - PubMed

ABSTRACT
Hemolytic uremic syndrome (HUS) is an uncommon cause of acute renal failure. Diarrhea-associated (D+) HUS, usually seen in children, is a common variety of HUS. HUS that is not associated with diarrhea (D-) is caused by a heterogeneous group of disorders. We report here a case of recurrent HUS (D-) in an adult female with hypocomplementemia.

No MeSH data available.


Related in: MedlinePlus