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Effect of the polysaccharide extract from the edible mushroom Pleurotus ostreatus against infectious bursal disease virus.

Selegean M, Putz MV, Rugea T - Int J Mol Sci (2009)

Bottom Line: The polysaccharide-containing extracellular fractions (EFs) of the edible mushroom Pleurotus ostreatus have immunomodulating effects.By adding 5% and 15% EF in the water intake, as compared to the reaction of the immune system in the previous experiment, the level of IBD antibodies was increased.This has led us to believe that by using this combination of BIAVAC and BIAROMVAC vaccine and EF from P. ostreatus we can obtain good results in stimulating the production of IBD antibodies in the period of the chicken first days of life, which are critical to broilers' survival.

View Article: PubMed Central - PubMed

Affiliation: Biology Department, West University of Timişoara, Romania. mirceaselegean@yahoo.com <mirceaselegean@yahoo.com>

ABSTRACT
The polysaccharide-containing extracellular fractions (EFs) of the edible mushroom Pleurotus ostreatus have immunomodulating effects. Being aware of these therapeutic effects of mushroom extracts, we have investigated the synergistic relations between these extracts and BIAVAC and BIAROMVAC vaccines. These vaccines target the stimulation of the immune system in commercial poultry, which are extremely vulnerable in the first days of their lives. By administrating EF with polysaccharides from P. ostreatus to unvaccinated broilers we have noticed slow stimulation of maternal antibodies against infectious bursal disease (IBD) starting from four weeks post hatching. For the broilers vaccinated with BIAVAC and BIAROMVAC vaccines a low to almost complete lack of IBD maternal antibodies has been recorded. By adding 5% and 15% EF in the water intake, as compared to the reaction of the immune system in the previous experiment, the level of IBD antibodies was increased. This has led us to believe that by using this combination of BIAVAC and BIAROMVAC vaccine and EF from P. ostreatus we can obtain good results in stimulating the production of IBD antibodies in the period of the chicken first days of life, which are critical to broilers' survival. This can be rationalized by the newly proposed reactivity biological activity (ReBiAc) principles by examining the parabolic relationship between EF administration and recorded biological activity.

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Related in: MedlinePlus

The effect of different concentrations of EF from P. ostreatus upon maternal IBD–AB titer in broilers vaccinated with BIAROMVAC vaccine. Thin trend line —: the titre of maternal IBD–AB (BIAROMVAC); Thick trend line : the titre of maternal IBD–AB in broiler BIAROMVAC + 5% (a) and BIAROMVAC + 15% EF (b). Weeks mean weeks post hatch, with the vaccination at the end of week 1.
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f3-ijms-10-03616: The effect of different concentrations of EF from P. ostreatus upon maternal IBD–AB titer in broilers vaccinated with BIAROMVAC vaccine. Thin trend line —: the titre of maternal IBD–AB (BIAROMVAC); Thick trend line : the titre of maternal IBD–AB in broiler BIAROMVAC + 5% (a) and BIAROMVAC + 15% EF (b). Weeks mean weeks post hatch, with the vaccination at the end of week 1.

Mentions: In this experiment, we have followed the production of IBD–AB antibodies in non-vaccinated chickens, vaccinated with BIAROMVAC, as compared to the ones under BIAROMVAC + 5% EF treatment and BIAROMVAC + 15% EF treatment, respectively. Thus, in chickens only vaccinated with BIAROMVAC vaccine, (like BIAVAC vaccine for the previous experiment), we can notice the temporary suppressive action of maternal IBD–AB antibodies production, in the first two weeks post-vaccinated inoculation (Figures 3a,b). All broilers had a maternal IBD–AB titer of 217 in the ELISA. These antibodies were below the estimated cut-off level in this ELISA. In the experimental groups, to which we have added 5% and 15% EF, respectively, all along the duration of the experiment, the antibodies level remained high, with a slow decrease at the beginning of the treatment (Figure 3, Table 5; p<0.0001).


Effect of the polysaccharide extract from the edible mushroom Pleurotus ostreatus against infectious bursal disease virus.

Selegean M, Putz MV, Rugea T - Int J Mol Sci (2009)

The effect of different concentrations of EF from P. ostreatus upon maternal IBD–AB titer in broilers vaccinated with BIAROMVAC vaccine. Thin trend line —: the titre of maternal IBD–AB (BIAROMVAC); Thick trend line : the titre of maternal IBD–AB in broiler BIAROMVAC + 5% (a) and BIAROMVAC + 15% EF (b). Weeks mean weeks post hatch, with the vaccination at the end of week 1.
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC2812818&req=5

f3-ijms-10-03616: The effect of different concentrations of EF from P. ostreatus upon maternal IBD–AB titer in broilers vaccinated with BIAROMVAC vaccine. Thin trend line —: the titre of maternal IBD–AB (BIAROMVAC); Thick trend line : the titre of maternal IBD–AB in broiler BIAROMVAC + 5% (a) and BIAROMVAC + 15% EF (b). Weeks mean weeks post hatch, with the vaccination at the end of week 1.
Mentions: In this experiment, we have followed the production of IBD–AB antibodies in non-vaccinated chickens, vaccinated with BIAROMVAC, as compared to the ones under BIAROMVAC + 5% EF treatment and BIAROMVAC + 15% EF treatment, respectively. Thus, in chickens only vaccinated with BIAROMVAC vaccine, (like BIAVAC vaccine for the previous experiment), we can notice the temporary suppressive action of maternal IBD–AB antibodies production, in the first two weeks post-vaccinated inoculation (Figures 3a,b). All broilers had a maternal IBD–AB titer of 217 in the ELISA. These antibodies were below the estimated cut-off level in this ELISA. In the experimental groups, to which we have added 5% and 15% EF, respectively, all along the duration of the experiment, the antibodies level remained high, with a slow decrease at the beginning of the treatment (Figure 3, Table 5; p<0.0001).

Bottom Line: The polysaccharide-containing extracellular fractions (EFs) of the edible mushroom Pleurotus ostreatus have immunomodulating effects.By adding 5% and 15% EF in the water intake, as compared to the reaction of the immune system in the previous experiment, the level of IBD antibodies was increased.This has led us to believe that by using this combination of BIAVAC and BIAROMVAC vaccine and EF from P. ostreatus we can obtain good results in stimulating the production of IBD antibodies in the period of the chicken first days of life, which are critical to broilers' survival.

View Article: PubMed Central - PubMed

Affiliation: Biology Department, West University of Timişoara, Romania. mirceaselegean@yahoo.com <mirceaselegean@yahoo.com>

ABSTRACT
The polysaccharide-containing extracellular fractions (EFs) of the edible mushroom Pleurotus ostreatus have immunomodulating effects. Being aware of these therapeutic effects of mushroom extracts, we have investigated the synergistic relations between these extracts and BIAVAC and BIAROMVAC vaccines. These vaccines target the stimulation of the immune system in commercial poultry, which are extremely vulnerable in the first days of their lives. By administrating EF with polysaccharides from P. ostreatus to unvaccinated broilers we have noticed slow stimulation of maternal antibodies against infectious bursal disease (IBD) starting from four weeks post hatching. For the broilers vaccinated with BIAVAC and BIAROMVAC vaccines a low to almost complete lack of IBD maternal antibodies has been recorded. By adding 5% and 15% EF in the water intake, as compared to the reaction of the immune system in the previous experiment, the level of IBD antibodies was increased. This has led us to believe that by using this combination of BIAVAC and BIAROMVAC vaccine and EF from P. ostreatus we can obtain good results in stimulating the production of IBD antibodies in the period of the chicken first days of life, which are critical to broilers' survival. This can be rationalized by the newly proposed reactivity biological activity (ReBiAc) principles by examining the parabolic relationship between EF administration and recorded biological activity.

Show MeSH
Related in: MedlinePlus