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Hydrodynamic properties of cyclodextrin molecules in dilute solutions.

Pavlov GM, Korneeva EV, Smolina NA, Schubert US - Eur. Biophys. J. (2009)

Bottom Line: Three well-known representatives of the cyclodextrin family were completely characterized by molecular hydrodynamics methods in three different solvents.For the first time the possibility of an estimation of velocity sedimentation coefficients s between 0.15 and 0.5 S by the numerical solution of the Lamm equation is shown.Comparison of the experimental hydrodynamic characteristics of the cyclodextrins with theoretical calculations for toroidal molecules allows an estimation of the thickness of the solvent layers on the surface of cyclodextrin molecules.

View Article: PubMed Central - PubMed

Affiliation: Laboratory of Macromolecular Chemistry and Nanoscience, Eindhoven University of Technology, P.O. Box 513, 5600 MB Eindhoven, The Netherlands. g.m.pavlov@tue.nl

ABSTRACT
Three well-known representatives of the cyclodextrin family were completely characterized by molecular hydrodynamics methods in three different solvents. For the first time the possibility of an estimation of velocity sedimentation coefficients s between 0.15 and 0.5 S by the numerical solution of the Lamm equation is shown. Comparison of the experimental hydrodynamic characteristics of the cyclodextrins with theoretical calculations for toroidal molecules allows an estimation of the thickness of the solvent layers on the surface of cyclodextrin molecules.

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Determination of the intrinsic viscosity values [η] (which are the intercepts, at c = 0, of the plots of ηsp/c (solid lines, Huggins plot) and ln ηr/c [dashed lines, Kramer plot] vs. c) for α-CD (1), β-CD (2), and γ-CD (3) in DMSO. The Huggins parameter kH are 0.39, 0.22, and 0, and the Kramer parameter kK are −0.11, −0.24, and −0.40 for α-, β-, and γ-CD, respectively
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Fig4: Determination of the intrinsic viscosity values [η] (which are the intercepts, at c = 0, of the plots of ηsp/c (solid lines, Huggins plot) and ln ηr/c [dashed lines, Kramer plot] vs. c) for α-CD (1), β-CD (2), and γ-CD (3) in DMSO. The Huggins parameter kH are 0.39, 0.22, and 0, and the Kramer parameter kK are −0.11, −0.24, and −0.40 for α-, β-, and γ-CD, respectively

Mentions: The values of both the sedimentation coefficient s and the diffusion coefficient D obtained at the concentrations given above were assumed to be equal to the values extrapolated to zero concentration. The solute concentrations practically correspond to the limiting dilution as the values of the Debye parameter (c[η]), describing dilution of a solution, is within the limits of 0.01 ≤ c[η] ≤ 0.03. The plots of ηsp/c and ln ηr/c as a function of c allowed us to determine the intrinsic viscosity, [η], of the cyclodextrins (Fig. 4). Table 2 represents the values of s, (f/fsph), D and [η] obtained.Fig. 4


Hydrodynamic properties of cyclodextrin molecules in dilute solutions.

Pavlov GM, Korneeva EV, Smolina NA, Schubert US - Eur. Biophys. J. (2009)

Determination of the intrinsic viscosity values [η] (which are the intercepts, at c = 0, of the plots of ηsp/c (solid lines, Huggins plot) and ln ηr/c [dashed lines, Kramer plot] vs. c) for α-CD (1), β-CD (2), and γ-CD (3) in DMSO. The Huggins parameter kH are 0.39, 0.22, and 0, and the Kramer parameter kK are −0.11, −0.24, and −0.40 for α-, β-, and γ-CD, respectively
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC2812710&req=5

Fig4: Determination of the intrinsic viscosity values [η] (which are the intercepts, at c = 0, of the plots of ηsp/c (solid lines, Huggins plot) and ln ηr/c [dashed lines, Kramer plot] vs. c) for α-CD (1), β-CD (2), and γ-CD (3) in DMSO. The Huggins parameter kH are 0.39, 0.22, and 0, and the Kramer parameter kK are −0.11, −0.24, and −0.40 for α-, β-, and γ-CD, respectively
Mentions: The values of both the sedimentation coefficient s and the diffusion coefficient D obtained at the concentrations given above were assumed to be equal to the values extrapolated to zero concentration. The solute concentrations practically correspond to the limiting dilution as the values of the Debye parameter (c[η]), describing dilution of a solution, is within the limits of 0.01 ≤ c[η] ≤ 0.03. The plots of ηsp/c and ln ηr/c as a function of c allowed us to determine the intrinsic viscosity, [η], of the cyclodextrins (Fig. 4). Table 2 represents the values of s, (f/fsph), D and [η] obtained.Fig. 4

Bottom Line: Three well-known representatives of the cyclodextrin family were completely characterized by molecular hydrodynamics methods in three different solvents.For the first time the possibility of an estimation of velocity sedimentation coefficients s between 0.15 and 0.5 S by the numerical solution of the Lamm equation is shown.Comparison of the experimental hydrodynamic characteristics of the cyclodextrins with theoretical calculations for toroidal molecules allows an estimation of the thickness of the solvent layers on the surface of cyclodextrin molecules.

View Article: PubMed Central - PubMed

Affiliation: Laboratory of Macromolecular Chemistry and Nanoscience, Eindhoven University of Technology, P.O. Box 513, 5600 MB Eindhoven, The Netherlands. g.m.pavlov@tue.nl

ABSTRACT
Three well-known representatives of the cyclodextrin family were completely characterized by molecular hydrodynamics methods in three different solvents. For the first time the possibility of an estimation of velocity sedimentation coefficients s between 0.15 and 0.5 S by the numerical solution of the Lamm equation is shown. Comparison of the experimental hydrodynamic characteristics of the cyclodextrins with theoretical calculations for toroidal molecules allows an estimation of the thickness of the solvent layers on the surface of cyclodextrin molecules.

Show MeSH
Related in: MedlinePlus