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The average body surface area of adult cancer patients in the UK: a multicentre retrospective study.

Sacco JJ, Botten J, Macbeth F, Bagust A, Clark P - PLoS ONE (2010)

Bottom Line: No standard BSA values for patients being treated in the United Kingdom are available on which to base dose and cost calculations.The overall mean BSA was 1.79 m(2) (95% CI 1.78-1.80) with a mean BSA for men of 1.91 m(2) (1.90-1.92) and 1.71 m(2) (1.70-1.72) for women.Results were consistent across the three centres.

View Article: PubMed Central - PubMed

Affiliation: Department of Medical Oncology, Clatterbridge Centre for Oncology, Merseyside, United Kingdom.

ABSTRACT
The majority of chemotherapy drugs are dosed based on body surface area (BSA). No standard BSA values for patients being treated in the United Kingdom are available on which to base dose and cost calculations. We therefore retrospectively assessed the BSA of patients receiving chemotherapy treatment at three oncology centres in the UK between 1(st) January 2005 and 31(st) December 2005.A total of 3613 patients receiving chemotherapy for head and neck, ovarian, lung, upper GI/pancreas, breast or colorectal cancers were included. The overall mean BSA was 1.79 m(2) (95% CI 1.78-1.80) with a mean BSA for men of 1.91 m(2) (1.90-1.92) and 1.71 m(2) (1.70-1.72) for women. Results were consistent across the three centres. No significant differences were noted between treatment in the adjuvant or palliative setting in patients with breast or colorectal cancer. However, statistically significant, albeit small, differences were detected between some tumour groups.In view of the consistency of results between three geographically distinct UK cancer centres, we believe the results of this study may be generalised and used in future costings and budgeting for new chemotherapy agents in the UK.

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Related in: MedlinePlus

Histograms depicting the distribution of body surface area in men and women undergoing chemotherapy.As illustrated, the distribution approximates normal in both sexes.
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pone-0008933-g002: Histograms depicting the distribution of body surface area in men and women undergoing chemotherapy.As illustrated, the distribution approximates normal in both sexes.

Mentions: The overall mean BSA for the patient population was 1.79 m2 (95% CI 1.78, 1.80). For both sexes, the BSA distribution was approximately normal as shown in figure 2. The mean BSA for men was 1.91 m2 (1.90, 1.91) compared to1.71 m2 (1.70, 1.72) for women, with a median of 1.90 and 1.70 respectively. Previous studies have employed the mean in preference to the median, a convention we have continued as the distribution approximated normal, and the mean better incorporates outliers which may have significant effects on costing.


The average body surface area of adult cancer patients in the UK: a multicentre retrospective study.

Sacco JJ, Botten J, Macbeth F, Bagust A, Clark P - PLoS ONE (2010)

Histograms depicting the distribution of body surface area in men and women undergoing chemotherapy.As illustrated, the distribution approximates normal in both sexes.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC2812484&req=5

pone-0008933-g002: Histograms depicting the distribution of body surface area in men and women undergoing chemotherapy.As illustrated, the distribution approximates normal in both sexes.
Mentions: The overall mean BSA for the patient population was 1.79 m2 (95% CI 1.78, 1.80). For both sexes, the BSA distribution was approximately normal as shown in figure 2. The mean BSA for men was 1.91 m2 (1.90, 1.91) compared to1.71 m2 (1.70, 1.72) for women, with a median of 1.90 and 1.70 respectively. Previous studies have employed the mean in preference to the median, a convention we have continued as the distribution approximated normal, and the mean better incorporates outliers which may have significant effects on costing.

Bottom Line: No standard BSA values for patients being treated in the United Kingdom are available on which to base dose and cost calculations.The overall mean BSA was 1.79 m(2) (95% CI 1.78-1.80) with a mean BSA for men of 1.91 m(2) (1.90-1.92) and 1.71 m(2) (1.70-1.72) for women.Results were consistent across the three centres.

View Article: PubMed Central - PubMed

Affiliation: Department of Medical Oncology, Clatterbridge Centre for Oncology, Merseyside, United Kingdom.

ABSTRACT
The majority of chemotherapy drugs are dosed based on body surface area (BSA). No standard BSA values for patients being treated in the United Kingdom are available on which to base dose and cost calculations. We therefore retrospectively assessed the BSA of patients receiving chemotherapy treatment at three oncology centres in the UK between 1(st) January 2005 and 31(st) December 2005.A total of 3613 patients receiving chemotherapy for head and neck, ovarian, lung, upper GI/pancreas, breast or colorectal cancers were included. The overall mean BSA was 1.79 m(2) (95% CI 1.78-1.80) with a mean BSA for men of 1.91 m(2) (1.90-1.92) and 1.71 m(2) (1.70-1.72) for women. Results were consistent across the three centres. No significant differences were noted between treatment in the adjuvant or palliative setting in patients with breast or colorectal cancer. However, statistically significant, albeit small, differences were detected between some tumour groups.In view of the consistency of results between three geographically distinct UK cancer centres, we believe the results of this study may be generalised and used in future costings and budgeting for new chemotherapy agents in the UK.

Show MeSH
Related in: MedlinePlus