Limits...
Recurrence pattern in squamous cell carcinoma of skin of lower extremities and abdominal wall (Kangri cancer) in Kashmir valley of Indian subcontinent: impact of various treatment modalities.

Teli MA, Khan NA, Darzi MA, Gupta M, Tufail A - Indian J Dermatol (2009)

Bottom Line: Two hundred and forty-four cases with a follow-up of 2-7 years were included for final analysis with stress on loco-regional relapse pattern and methods of treatment evolved and used at our institute from time to time.Statistical analysis was done using yates corrected Chi-square test and odds ratio analysis.Our results favor the use of post operative radiotherapy to primary and prophylactic treatment of regional nodes on the lines of head and neck tumors in these cases.

View Article: PubMed Central - PubMed

Affiliation: Department of Radiation Oncology, SKIMS, Soura, Srinagar - 190 011, Kashmir, India. ashrafteli2004@yahoo.com

ABSTRACT

Background: The spectrum of skin cancer in Kashmir valley is drastically different from the rest of the country. Maxwell was the first to report skin cancer of lower extremities in Kashmiri population, developing on/over erythema ab igne, and attributed it to the use/or exposure of Kangri. These tumors have an aggressive biological behavior with a substantial risk of loco-regional metastasis in 30-50% cases. Because of unique geographical distribution of Kangri cancer, there is dearth of literature regarding the natural history, loco-regional and distant metastatic pattern and treatment recommendations in these tumors.

Aims: To study the metastatic pattern of these skin tumors and to assess the impact of various treatment modalities and use of prophylactic nodal treatment in this clinical entity.

Methods: The retrospective study (study period 1993-2005) included 266 patients of squamous cell carcinoma of skin of lower extremities and abdominal wall. Two hundred and forty-four cases with a follow-up of 2-7 years were included for final analysis with stress on loco-regional relapse pattern and methods of treatment evolved and used at our institute from time to time. Statistical analysis was done using yates corrected Chi-square test and odds ratio analysis.

Results: Our results favor the use of post operative radiotherapy to primary and prophylactic treatment of regional nodes on the lines of head and neck tumors in these cases.

Conclusion: Post operative radiotherapy significantly decreases the loco-regional recurrences and a trial of prophylactic nodal irradiation is justified in a selected group of such patients.

No MeSH data available.


Related in: MedlinePlus

A T3 Kangri cancer
© Copyright Policy - open-access
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC2807710&req=5

Figure 0003: A T3 Kangri cancer

Mentions: Non-melanoma skin cancer is the most common form of skin cancer with basal cell carcinoma outnumbering the squamous cell carcinoma in majority of the geographical regions of world.[12] The most obvious and significant cause is exposure to sunlight (ultraviolet radiation) and as such, it usually occurs in sun exposed anatomical sites[3] However, various studies from India consistently report squamous cell carcinoma as the most prevalent skin malignancy.[45] Clinical spectrum of skin cancer in Kashmir valley is different from the rest of the country. Maxwell, in 1879, was the first to report skin cancer of the lower extremities from Kashmir valley and attributed it to the use/exposure of Kangri [Figure 1] – an indigenous fire pot used and tucked in between the thighs to generate warmth during the winter months.[6] Kangri cancer usually starts as a papular growth on/over pre existing thermal keratotic lesions called erythema ab igne [Figure 2]. With time these lesions usually ulcerate and grow exponentially [Figure 3]. These tumors have an aggressive biological behavior with a substantial risk of loco-regional metastasis in 20-50% cases.[7–9] [Figures 4 and 5] Because of its unique geographical distribution, there is dearth of literature regarding the natural history and the spectrum of loco-regional and distant metastatic pattern in these tumors. The present study was undertaken to study the metastatic pattern in these tumors and to assess the impact of various treatment modalities used in this clinical entity.


Recurrence pattern in squamous cell carcinoma of skin of lower extremities and abdominal wall (Kangri cancer) in Kashmir valley of Indian subcontinent: impact of various treatment modalities.

Teli MA, Khan NA, Darzi MA, Gupta M, Tufail A - Indian J Dermatol (2009)

A T3 Kangri cancer
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC2807710&req=5

Figure 0003: A T3 Kangri cancer
Mentions: Non-melanoma skin cancer is the most common form of skin cancer with basal cell carcinoma outnumbering the squamous cell carcinoma in majority of the geographical regions of world.[12] The most obvious and significant cause is exposure to sunlight (ultraviolet radiation) and as such, it usually occurs in sun exposed anatomical sites[3] However, various studies from India consistently report squamous cell carcinoma as the most prevalent skin malignancy.[45] Clinical spectrum of skin cancer in Kashmir valley is different from the rest of the country. Maxwell, in 1879, was the first to report skin cancer of the lower extremities from Kashmir valley and attributed it to the use/exposure of Kangri [Figure 1] – an indigenous fire pot used and tucked in between the thighs to generate warmth during the winter months.[6] Kangri cancer usually starts as a papular growth on/over pre existing thermal keratotic lesions called erythema ab igne [Figure 2]. With time these lesions usually ulcerate and grow exponentially [Figure 3]. These tumors have an aggressive biological behavior with a substantial risk of loco-regional metastasis in 20-50% cases.[7–9] [Figures 4 and 5] Because of its unique geographical distribution, there is dearth of literature regarding the natural history and the spectrum of loco-regional and distant metastatic pattern in these tumors. The present study was undertaken to study the metastatic pattern in these tumors and to assess the impact of various treatment modalities used in this clinical entity.

Bottom Line: Two hundred and forty-four cases with a follow-up of 2-7 years were included for final analysis with stress on loco-regional relapse pattern and methods of treatment evolved and used at our institute from time to time.Statistical analysis was done using yates corrected Chi-square test and odds ratio analysis.Our results favor the use of post operative radiotherapy to primary and prophylactic treatment of regional nodes on the lines of head and neck tumors in these cases.

View Article: PubMed Central - PubMed

Affiliation: Department of Radiation Oncology, SKIMS, Soura, Srinagar - 190 011, Kashmir, India. ashrafteli2004@yahoo.com

ABSTRACT

Background: The spectrum of skin cancer in Kashmir valley is drastically different from the rest of the country. Maxwell was the first to report skin cancer of lower extremities in Kashmiri population, developing on/over erythema ab igne, and attributed it to the use/or exposure of Kangri. These tumors have an aggressive biological behavior with a substantial risk of loco-regional metastasis in 30-50% cases. Because of unique geographical distribution of Kangri cancer, there is dearth of literature regarding the natural history, loco-regional and distant metastatic pattern and treatment recommendations in these tumors.

Aims: To study the metastatic pattern of these skin tumors and to assess the impact of various treatment modalities and use of prophylactic nodal treatment in this clinical entity.

Methods: The retrospective study (study period 1993-2005) included 266 patients of squamous cell carcinoma of skin of lower extremities and abdominal wall. Two hundred and forty-four cases with a follow-up of 2-7 years were included for final analysis with stress on loco-regional relapse pattern and methods of treatment evolved and used at our institute from time to time. Statistical analysis was done using yates corrected Chi-square test and odds ratio analysis.

Results: Our results favor the use of post operative radiotherapy to primary and prophylactic treatment of regional nodes on the lines of head and neck tumors in these cases.

Conclusion: Post operative radiotherapy significantly decreases the loco-regional recurrences and a trial of prophylactic nodal irradiation is justified in a selected group of such patients.

No MeSH data available.


Related in: MedlinePlus