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Advances in multimodality molecular imaging.

Zaidi H, Prasad R - J Med Phys (2009)

Bottom Line: The introduction of combined PET/CT systems in clinical setting has revolutionized the practice of diagnostic imaging.On the other hand, combining PET with Magnetic Resonance Imaging (MRI) in a single gantry is technically more challenging owing to the strong magnetic fields.Nevertheless, significant progress has been made resulting in the design of few preclinical PET systems and one human prototype dedicated for simultaneous PET/MR brain imaging.

View Article: PubMed Central - PubMed

Affiliation: Geneva University Hospital, Division of Nuclear Medicine, CH-1211 Geneva, Switzerland.

ABSTRACT
Multimodality molecular imaging using high resolution positron emission tomography (PET) combined with other modalities is now playing a pivotal role in basic and clinical research. The introduction of combined PET/CT systems in clinical setting has revolutionized the practice of diagnostic imaging. The complementarity between the intrinsically aligned anatomic (CT) and functional or metabolic (PET) information provided in a "one-stop shop" and the possibility to use CT images for attenuation correction of the PET data has been the driving force behind the success of this technology. On the other hand, combining PET with Magnetic Resonance Imaging (MRI) in a single gantry is technically more challenging owing to the strong magnetic fields. Nevertheless, significant progress has been made resulting in the design of few preclinical PET systems and one human prototype dedicated for simultaneous PET/MR brain imaging. This paper discusses recent advances in PET instrumentation and the advantages and challenges of multimodality imaging systems. Future opportunities and the challenges facing the adoption of multimodality imaging instrumentation will also be addressed.

No MeSH data available.


Related in: MedlinePlus

Illustration of a clinical PET/CT study showing the limitations of 18F-FDG for the detection of hepatic metastases whereas two metastases were clearly visible on the 18F-FDopa study
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Figure 0003: Illustration of a clinical PET/CT study showing the limitations of 18F-FDG for the detection of hepatic metastases whereas two metastases were clearly visible on the 18F-FDopa study

Mentions: The wide adoption of FDG (molecule of the century) and a multitude of novel radiotracers have clearly demonstrated the enormous potential of PET-CT as an emerging discipline in the field of molecular imaging. It can arguably be stated that FDG-PET, as a single modality, has made an everlasting impact on the specialty of nuclear medicine. In fact, it has rejuvenated the field and has changed its image in the medical community. However, FDG-PET/CT has limited impact in many malignancies presenting with low FDG avidity, e.g. prostate cancer, hepatic metastases …etc, where more specific tracers should be used [Figure 3].


Advances in multimodality molecular imaging.

Zaidi H, Prasad R - J Med Phys (2009)

Illustration of a clinical PET/CT study showing the limitations of 18F-FDG for the detection of hepatic metastases whereas two metastases were clearly visible on the 18F-FDopa study
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC2807675&req=5

Figure 0003: Illustration of a clinical PET/CT study showing the limitations of 18F-FDG for the detection of hepatic metastases whereas two metastases were clearly visible on the 18F-FDopa study
Mentions: The wide adoption of FDG (molecule of the century) and a multitude of novel radiotracers have clearly demonstrated the enormous potential of PET-CT as an emerging discipline in the field of molecular imaging. It can arguably be stated that FDG-PET, as a single modality, has made an everlasting impact on the specialty of nuclear medicine. In fact, it has rejuvenated the field and has changed its image in the medical community. However, FDG-PET/CT has limited impact in many malignancies presenting with low FDG avidity, e.g. prostate cancer, hepatic metastases …etc, where more specific tracers should be used [Figure 3].

Bottom Line: The introduction of combined PET/CT systems in clinical setting has revolutionized the practice of diagnostic imaging.On the other hand, combining PET with Magnetic Resonance Imaging (MRI) in a single gantry is technically more challenging owing to the strong magnetic fields.Nevertheless, significant progress has been made resulting in the design of few preclinical PET systems and one human prototype dedicated for simultaneous PET/MR brain imaging.

View Article: PubMed Central - PubMed

Affiliation: Geneva University Hospital, Division of Nuclear Medicine, CH-1211 Geneva, Switzerland.

ABSTRACT
Multimodality molecular imaging using high resolution positron emission tomography (PET) combined with other modalities is now playing a pivotal role in basic and clinical research. The introduction of combined PET/CT systems in clinical setting has revolutionized the practice of diagnostic imaging. The complementarity between the intrinsically aligned anatomic (CT) and functional or metabolic (PET) information provided in a "one-stop shop" and the possibility to use CT images for attenuation correction of the PET data has been the driving force behind the success of this technology. On the other hand, combining PET with Magnetic Resonance Imaging (MRI) in a single gantry is technically more challenging owing to the strong magnetic fields. Nevertheless, significant progress has been made resulting in the design of few preclinical PET systems and one human prototype dedicated for simultaneous PET/MR brain imaging. This paper discusses recent advances in PET instrumentation and the advantages and challenges of multimodality imaging systems. Future opportunities and the challenges facing the adoption of multimodality imaging instrumentation will also be addressed.

No MeSH data available.


Related in: MedlinePlus