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Endothelin receptor antagonist and airway dysfunction in pulmonary arterial hypertension.

Droste AS, Rohde D, Voelkers M, Filusch A, Bruckner T, Borst MM, Katus HA, Meyer FJ - Respir. Res. (2009)

Bottom Line: At baseline, maximal expiratory flow at 50 and 25% vital capacity were reduced to 65 +/- 25 and 45 +/- 24% predicted.During 3 and 12 months of treatment, 6-MWT increased by 32 +/- 19 and 53 +/- 69 m, respectively; p < 0.01; whereas sPAP decreased by 7 +/- 14 and 10 +/- 19 mmHg, respectively; p < 0.05.NT-proBNP serum levels tended to be reduced by 123 +/- 327 and by 529 +/- 1942 ng/L; p = 0.11).

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Cardiology, Angiology and Respiratory Medicine, Heidelberg, Germany. an.dros@web.de

ABSTRACT

Background: In idiopathic pulmonary arterial hypertension (IPAH), peripheral airway obstruction is frequent. This is partially attributed to the mediator dysbalance, particularly an excess of endothelin-1 (ET-1), to increased pulmonary vascular and airway tonus and to local inflammation. Bosentan (ET-1 receptor antagonist) improves pulmonary hemodynamics, exercise limitation, and disease severity in IPAH. We hypothesized that bosentan might affect airway obstruction.

Methods: In 32 IPAH-patients (19 female, WHO functional class II (n = 10), III (n = 22); (data presented as mean +/- standard deviation) pulmonary vascular resistance (11 +/- 5 Wood units), lung function, 6 minute walk test (6-MWT; 364 +/- 363.7 (range 179.0-627.0) m), systolic pulmonary artery pressure, sPAP, 79 +/- 19 mmHg), and NT-proBNP serum levels (1427 +/- 2162.7 (range 59.3-10342.0) ng/L) were measured at baseline, after 3 and 12 months of oral bosentan (125 mg twice per day).

Results and discussion: At baseline, maximal expiratory flow at 50 and 25% vital capacity were reduced to 65 +/- 25 and 45 +/- 24% predicted. Total lung capacity was 95.6 +/- 12.5% predicted and residual volume was 109 +/- 21.4% predicted. During 3 and 12 months of treatment, 6-MWT increased by 32 +/- 19 and 53 +/- 69 m, respectively; p < 0.01; whereas sPAP decreased by 7 +/- 14 and 10 +/- 19 mmHg, respectively; p < 0.05. NT-proBNP serum levels tended to be reduced by 123 +/- 327 and by 529 +/- 1942 ng/L; p = 0.11). There was no difference in expiratory flows or lung volumes during 3 and 12 months.

Conclusion: This study gives first evidence in IPAH, that during long-term bosentan, improvement of hemodynamics, functional parameters or serum biomarker occur independently from persisting peripheral airway obstruction.

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Related in: MedlinePlus

Changes in maximal expiratory flow (MEF) at (a) 75%, (b) 50%, (c) 25% of remaining vital capacity after 3 and 12 months of treatment in 32 patients with IPAH.
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Figure 2: Changes in maximal expiratory flow (MEF) at (a) 75%, (b) 50%, (c) 25% of remaining vital capacity after 3 and 12 months of treatment in 32 patients with IPAH.

Mentions: However, expiratory airflow during the second half of the expiratory phase was reduced, indicating peripheral airway obstruction (Table 1). After 3 and 12 months of treatment, the limitation in expiratory air flows persisted (Figure 23 and 4).


Endothelin receptor antagonist and airway dysfunction in pulmonary arterial hypertension.

Droste AS, Rohde D, Voelkers M, Filusch A, Bruckner T, Borst MM, Katus HA, Meyer FJ - Respir. Res. (2009)

Changes in maximal expiratory flow (MEF) at (a) 75%, (b) 50%, (c) 25% of remaining vital capacity after 3 and 12 months of treatment in 32 patients with IPAH.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC2807428&req=5

Figure 2: Changes in maximal expiratory flow (MEF) at (a) 75%, (b) 50%, (c) 25% of remaining vital capacity after 3 and 12 months of treatment in 32 patients with IPAH.
Mentions: However, expiratory airflow during the second half of the expiratory phase was reduced, indicating peripheral airway obstruction (Table 1). After 3 and 12 months of treatment, the limitation in expiratory air flows persisted (Figure 23 and 4).

Bottom Line: At baseline, maximal expiratory flow at 50 and 25% vital capacity were reduced to 65 +/- 25 and 45 +/- 24% predicted.During 3 and 12 months of treatment, 6-MWT increased by 32 +/- 19 and 53 +/- 69 m, respectively; p < 0.01; whereas sPAP decreased by 7 +/- 14 and 10 +/- 19 mmHg, respectively; p < 0.05.NT-proBNP serum levels tended to be reduced by 123 +/- 327 and by 529 +/- 1942 ng/L; p = 0.11).

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Cardiology, Angiology and Respiratory Medicine, Heidelberg, Germany. an.dros@web.de

ABSTRACT

Background: In idiopathic pulmonary arterial hypertension (IPAH), peripheral airway obstruction is frequent. This is partially attributed to the mediator dysbalance, particularly an excess of endothelin-1 (ET-1), to increased pulmonary vascular and airway tonus and to local inflammation. Bosentan (ET-1 receptor antagonist) improves pulmonary hemodynamics, exercise limitation, and disease severity in IPAH. We hypothesized that bosentan might affect airway obstruction.

Methods: In 32 IPAH-patients (19 female, WHO functional class II (n = 10), III (n = 22); (data presented as mean +/- standard deviation) pulmonary vascular resistance (11 +/- 5 Wood units), lung function, 6 minute walk test (6-MWT; 364 +/- 363.7 (range 179.0-627.0) m), systolic pulmonary artery pressure, sPAP, 79 +/- 19 mmHg), and NT-proBNP serum levels (1427 +/- 2162.7 (range 59.3-10342.0) ng/L) were measured at baseline, after 3 and 12 months of oral bosentan (125 mg twice per day).

Results and discussion: At baseline, maximal expiratory flow at 50 and 25% vital capacity were reduced to 65 +/- 25 and 45 +/- 24% predicted. Total lung capacity was 95.6 +/- 12.5% predicted and residual volume was 109 +/- 21.4% predicted. During 3 and 12 months of treatment, 6-MWT increased by 32 +/- 19 and 53 +/- 69 m, respectively; p < 0.01; whereas sPAP decreased by 7 +/- 14 and 10 +/- 19 mmHg, respectively; p < 0.05. NT-proBNP serum levels tended to be reduced by 123 +/- 327 and by 529 +/- 1942 ng/L; p = 0.11). There was no difference in expiratory flows or lung volumes during 3 and 12 months.

Conclusion: This study gives first evidence in IPAH, that during long-term bosentan, improvement of hemodynamics, functional parameters or serum biomarker occur independently from persisting peripheral airway obstruction.

Show MeSH
Related in: MedlinePlus