Limits...
Impact of palivizumab on RSV hospitalizations for children with hemodynamically significant congenital heart disease.

Chang RK, Chen AY - Pediatr Cardiol (2009)

Bottom Line: That represents a 19% reduction in RSV hospitalizations among HS-CHD patients after 2003.The 19% decrease in RSV hospitalizations equates to seven fewer hospitalizations (76 hospital days) per year among HS-CHD patients.We conclude that, since the recommendation of palivizumab for children with HS-CHD in 2003, the impact on RSV hospitalizations in California among HS-CHD patients has been limited.

View Article: PubMed Central - PubMed

Affiliation: Division of Cardiology, Department of Pediatrics, Harbor-UCLA Medical Center, 1000 West Carson Street, Box 491, Torrance, CA 90509, USA. rkchang@ucla.edu

ABSTRACT
The objective of this study was to evaluate the impact of palivizumab prophylaxis on respiratory syncytial virus (RSV) hospitalizations among children with hemodynamically significant congenital heart disease (CHD). In 2003, the American Academy of Pediatrics (AAP) revised the bronchiolitis policy statement and recommended the use of palivizumab in children <24 months old with hemodynamically significant CHD (HS-CHD). California statewide hospital discharge data from years 2000-2002 (pre-AAP policy revision) were compared to those from years 2004-2006 (post-AAP policy revision). Hospitalizations due to RSV bronchiolitis for children <2 years of age were identified by IDC-9 CM codes 4661.1, 480.1, and 079.6 as the Principal Diagnosis. Children with CHD and children with HS-CHD were identified by the codiagnoses. The overall RSV hospitalization rate was 71 per 10,000 children <2 years of age. Of all RSV hospitalizations, 3.0% were among children with CHD, and 0.50% among children with HS-CHD. HS-CHD patients accounted for 0.56% of RSV hospitalizations in 2000-2002, compared to 0.46% RSV hospitalizations in 2004-2006. That represents a 19% reduction in RSV hospitalizations among HS-CHD patients after 2003. The 19% decrease in RSV hospitalizations equates to seven fewer hospitalizations (76 hospital days) per year among HS-CHD patients. We conclude that, since the recommendation of palivizumab for children with HS-CHD in 2003, the impact on RSV hospitalizations in California among HS-CHD patients has been limited. Considering the high cost of palivizumab administration, the cost-benefit of RSV prophylaxis with palivizumab warrants further investigation.

Show MeSH

Related in: MedlinePlus

Annual rate of RSV-related hospitalizations per 1000 infants <2 years of age in California, 2000–2006
© Copyright Policy
Related In: Results  -  Collection


getmorefigures.php?uid=PMC2807022&req=5

Fig1: Annual rate of RSV-related hospitalizations per 1000 infants <2 years of age in California, 2000–2006

Mentions: There were a total of 53,207 RSV-related hospitalizations among children <2 years of age in California from 2000 to 2006. The number of hospitalizations fluctuated over the years, ranging from 6336 in 2006 to 8712 in 2002. When calculated as the rate per 10,000 children <2 years of age, the overall RSV hospitalization rate was 71 per 10,000 children <2 years of age, ranging from 57 per 10,000 in 2006 to 83 per 10,000 in 2002. The RSV hospitalization rate decreased from 2000 to 2006 (Fig. 1) (R = 0.89, p < 0.01). Overall, 3.0% of all RSV hospitalizations were patients with CHD, and 0.5% of all RSV hospitalizations were patients with HS-CHD.Fig. 1


Impact of palivizumab on RSV hospitalizations for children with hemodynamically significant congenital heart disease.

Chang RK, Chen AY - Pediatr Cardiol (2009)

Annual rate of RSV-related hospitalizations per 1000 infants <2 years of age in California, 2000–2006
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC2807022&req=5

Fig1: Annual rate of RSV-related hospitalizations per 1000 infants <2 years of age in California, 2000–2006
Mentions: There were a total of 53,207 RSV-related hospitalizations among children <2 years of age in California from 2000 to 2006. The number of hospitalizations fluctuated over the years, ranging from 6336 in 2006 to 8712 in 2002. When calculated as the rate per 10,000 children <2 years of age, the overall RSV hospitalization rate was 71 per 10,000 children <2 years of age, ranging from 57 per 10,000 in 2006 to 83 per 10,000 in 2002. The RSV hospitalization rate decreased from 2000 to 2006 (Fig. 1) (R = 0.89, p < 0.01). Overall, 3.0% of all RSV hospitalizations were patients with CHD, and 0.5% of all RSV hospitalizations were patients with HS-CHD.Fig. 1

Bottom Line: That represents a 19% reduction in RSV hospitalizations among HS-CHD patients after 2003.The 19% decrease in RSV hospitalizations equates to seven fewer hospitalizations (76 hospital days) per year among HS-CHD patients.We conclude that, since the recommendation of palivizumab for children with HS-CHD in 2003, the impact on RSV hospitalizations in California among HS-CHD patients has been limited.

View Article: PubMed Central - PubMed

Affiliation: Division of Cardiology, Department of Pediatrics, Harbor-UCLA Medical Center, 1000 West Carson Street, Box 491, Torrance, CA 90509, USA. rkchang@ucla.edu

ABSTRACT
The objective of this study was to evaluate the impact of palivizumab prophylaxis on respiratory syncytial virus (RSV) hospitalizations among children with hemodynamically significant congenital heart disease (CHD). In 2003, the American Academy of Pediatrics (AAP) revised the bronchiolitis policy statement and recommended the use of palivizumab in children <24 months old with hemodynamically significant CHD (HS-CHD). California statewide hospital discharge data from years 2000-2002 (pre-AAP policy revision) were compared to those from years 2004-2006 (post-AAP policy revision). Hospitalizations due to RSV bronchiolitis for children <2 years of age were identified by IDC-9 CM codes 4661.1, 480.1, and 079.6 as the Principal Diagnosis. Children with CHD and children with HS-CHD were identified by the codiagnoses. The overall RSV hospitalization rate was 71 per 10,000 children <2 years of age. Of all RSV hospitalizations, 3.0% were among children with CHD, and 0.50% among children with HS-CHD. HS-CHD patients accounted for 0.56% of RSV hospitalizations in 2000-2002, compared to 0.46% RSV hospitalizations in 2004-2006. That represents a 19% reduction in RSV hospitalizations among HS-CHD patients after 2003. The 19% decrease in RSV hospitalizations equates to seven fewer hospitalizations (76 hospital days) per year among HS-CHD patients. We conclude that, since the recommendation of palivizumab for children with HS-CHD in 2003, the impact on RSV hospitalizations in California among HS-CHD patients has been limited. Considering the high cost of palivizumab administration, the cost-benefit of RSV prophylaxis with palivizumab warrants further investigation.

Show MeSH
Related in: MedlinePlus