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Human insulin/IGF-1 and familial longevity at middle age.

Rozing MP, Westendorp RG, Frölich M, de Craen AJ, Beekman M, Heijmans BT, Mooijaart SP, Blauw GJ, Slagboom PE, van Heemst D, Leiden Longevity Study (LLS) Gro - Aging (Albany NY) (2009)

Bottom Line: Recently, we have shown that compared to controls, long-lived familial nonagenarians (mean age: 93.4 years) from the Leiden Longevity Study displayed a lower mortality rate, and their middle-aged offspring displayed a lower prevalence of cardio-metabolic diseases, including diabetes mellitus.The evolutionarily conserved insulin/IGF-1 signaling (IIS) pathway has been implicated in longevity in model organisms, but its relevance for human longevity has generated much controversy.Here, we show that compared to their partners, the offspring of familial nonagenarians displayed similar non-fasted serum levels of IGF-1, IGFBP3 and insulin but lower non-fasted serum levels of glucose, indicating that familial longevity is associated with differences in insulin sensitivity.

View Article: PubMed Central - PubMed

Affiliation: Department of Gerontology and Geriatrics, Leiden University Medical Center, 2300 RC, Leiden, the Netherlands.

ABSTRACT
Recently, we have shown that compared to controls, long-lived familial nonagenarians (mean age: 93.4 years) from the Leiden Longevity Study displayed a lower mortality rate, and their middle-aged offspring displayed a lower prevalence of cardio-metabolic diseases, including diabetes mellitus. The evolutionarily conserved insulin/IGF-1 signaling (IIS) pathway has been implicated in longevity in model organisms, but its relevance for human longevity has generated much controversy. Here, we show that compared to their partners, the offspring of familial nonagenarians displayed similar non-fasted serum levels of IGF-1, IGFBP3 and insulin but lower non-fasted serum levels of glucose, indicating that familial longevity is associated with differences in insulin sensitivity.

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Related in: MedlinePlus

Cumulative distribution curves of serum IGF-1 levels, serum IGFBP3 levels and height.                                            Cumulative distribution curves of IGF-1 levels for offspring and partners                                            among females (A) and males (B); Cumulative distribution                                            curves of IGFBP3 levels for offspring and partners among females (C)                                            and males (D); Cumulative distribution curves of height for                                            offspring and partners among females (E) and males (F). Black                                            lines represent offspring, gray lines represent partners.
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Figure 1: Cumulative distribution curves of serum IGF-1 levels, serum IGFBP3 levels and height. Cumulative distribution curves of IGF-1 levels for offspring and partners among females (A) and males (B); Cumulative distribution curves of IGFBP3 levels for offspring and partners among females (C) and males (D); Cumulative distribution curves of height for offspring and partners among females (E) and males (F). Black lines represent offspring, gray lines represent partners.

Mentions: Next, we determined whether the distribution of serum IGF-1 axis parameters and anthropometrical parameters were different between offspring and partners. Figure 1 displays the cumulative distributions of IGF-1, IGFBP3 and height among partners and offspring for both sexes separately. No differences in height were observed between offspring and partners in the tails of the IGF-1 and IGFBP3 distribution curves. Taken together, the cumulative distribution curves do not suggest enrichment of high or low IGF-1 axis parameters nor large or short statures among the groups of offspring versus partners.


Human insulin/IGF-1 and familial longevity at middle age.

Rozing MP, Westendorp RG, Frölich M, de Craen AJ, Beekman M, Heijmans BT, Mooijaart SP, Blauw GJ, Slagboom PE, van Heemst D, Leiden Longevity Study (LLS) Gro - Aging (Albany NY) (2009)

Cumulative distribution curves of serum IGF-1 levels, serum IGFBP3 levels and height.                                            Cumulative distribution curves of IGF-1 levels for offspring and partners                                            among females (A) and males (B); Cumulative distribution                                            curves of IGFBP3 levels for offspring and partners among females (C)                                            and males (D); Cumulative distribution curves of height for                                            offspring and partners among females (E) and males (F). Black                                            lines represent offspring, gray lines represent partners.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC2806046&req=5

Figure 1: Cumulative distribution curves of serum IGF-1 levels, serum IGFBP3 levels and height. Cumulative distribution curves of IGF-1 levels for offspring and partners among females (A) and males (B); Cumulative distribution curves of IGFBP3 levels for offspring and partners among females (C) and males (D); Cumulative distribution curves of height for offspring and partners among females (E) and males (F). Black lines represent offspring, gray lines represent partners.
Mentions: Next, we determined whether the distribution of serum IGF-1 axis parameters and anthropometrical parameters were different between offspring and partners. Figure 1 displays the cumulative distributions of IGF-1, IGFBP3 and height among partners and offspring for both sexes separately. No differences in height were observed between offspring and partners in the tails of the IGF-1 and IGFBP3 distribution curves. Taken together, the cumulative distribution curves do not suggest enrichment of high or low IGF-1 axis parameters nor large or short statures among the groups of offspring versus partners.

Bottom Line: Recently, we have shown that compared to controls, long-lived familial nonagenarians (mean age: 93.4 years) from the Leiden Longevity Study displayed a lower mortality rate, and their middle-aged offspring displayed a lower prevalence of cardio-metabolic diseases, including diabetes mellitus.The evolutionarily conserved insulin/IGF-1 signaling (IIS) pathway has been implicated in longevity in model organisms, but its relevance for human longevity has generated much controversy.Here, we show that compared to their partners, the offspring of familial nonagenarians displayed similar non-fasted serum levels of IGF-1, IGFBP3 and insulin but lower non-fasted serum levels of glucose, indicating that familial longevity is associated with differences in insulin sensitivity.

View Article: PubMed Central - PubMed

Affiliation: Department of Gerontology and Geriatrics, Leiden University Medical Center, 2300 RC, Leiden, the Netherlands.

ABSTRACT
Recently, we have shown that compared to controls, long-lived familial nonagenarians (mean age: 93.4 years) from the Leiden Longevity Study displayed a lower mortality rate, and their middle-aged offspring displayed a lower prevalence of cardio-metabolic diseases, including diabetes mellitus. The evolutionarily conserved insulin/IGF-1 signaling (IIS) pathway has been implicated in longevity in model organisms, but its relevance for human longevity has generated much controversy. Here, we show that compared to their partners, the offspring of familial nonagenarians displayed similar non-fasted serum levels of IGF-1, IGFBP3 and insulin but lower non-fasted serum levels of glucose, indicating that familial longevity is associated with differences in insulin sensitivity.

Show MeSH
Related in: MedlinePlus