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Inhibition of S6K by resveratrol: in search of the purpose.

Blagosklonny MV - Aging (Albany NY) (2009)

View Article: PubMed Central - PubMed

Affiliation: Department of Cell Stress Biology, Roswell Park Cancer Institute, Buffalo, NY 14263, USA. Blagosklonny@oncotarget.com

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age-related diseases and extends lifespan in several species... downstream target of mTOR (mammalian Target of Rapamycin)... nutrients, growth factors and hormones, the mTOR/S6K pathway promotes cellular resverat- rol may exert its anti-aging effect... These cytotoxic agents are used as anti-cancer drugs, although nature did not create them for that purpose... Rapamycin is also indicated for the therapy of almost all age-related diseases Thus, the anti-aging effect of resveratrol may be just a side effect of targeting S6K, sirtuins and AMPK... indirect arguments about why animals might have evolved ‘target of resveratrol' for their benefit (in agreement with the xenohormesis model)... environment, when animals live long enough to experience aging, the aging suppressant side effect becomes apparent.

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The nutrient-sensing pathway as a target of resveratrol.In red, targets                                            that are inhibited by resveratrol. In green, targets that are activated by                                            resveratrol.
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Figure 1: The nutrient-sensing pathway as a target of resveratrol.In red, targets that are inhibited by resveratrol. In green, targets that are activated by resveratrol.

Mentions: In addition, resveratrol activates sirtuins [2,24-25] and AMPK [6,26], which may antagonize the TOR pathway downstream and upstream, respectively (Figure 1). It has been suggested that sirtuins and mTOR may be involved in the same longevity pathway [27]. By inhibiting S6K and activating sirtuins, resverat- rol may exert its anti-aging effect. But why would plants produce an anti-aging drug?


Inhibition of S6K by resveratrol: in search of the purpose.

Blagosklonny MV - Aging (Albany NY) (2009)

The nutrient-sensing pathway as a target of resveratrol.In red, targets                                            that are inhibited by resveratrol. In green, targets that are activated by                                            resveratrol.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC2806036&req=5

Figure 1: The nutrient-sensing pathway as a target of resveratrol.In red, targets that are inhibited by resveratrol. In green, targets that are activated by resveratrol.
Mentions: In addition, resveratrol activates sirtuins [2,24-25] and AMPK [6,26], which may antagonize the TOR pathway downstream and upstream, respectively (Figure 1). It has been suggested that sirtuins and mTOR may be involved in the same longevity pathway [27]. By inhibiting S6K and activating sirtuins, resverat- rol may exert its anti-aging effect. But why would plants produce an anti-aging drug?

View Article: PubMed Central - PubMed

Affiliation: Department of Cell Stress Biology, Roswell Park Cancer Institute, Buffalo, NY 14263, USA. Blagosklonny@oncotarget.com

AUTOMATICALLY GENERATED EXCERPT
Please rate it.

age-related diseases and extends lifespan in several species... downstream target of mTOR (mammalian Target of Rapamycin)... nutrients, growth factors and hormones, the mTOR/S6K pathway promotes cellular resverat- rol may exert its anti-aging effect... These cytotoxic agents are used as anti-cancer drugs, although nature did not create them for that purpose... Rapamycin is also indicated for the therapy of almost all age-related diseases Thus, the anti-aging effect of resveratrol may be just a side effect of targeting S6K, sirtuins and AMPK... indirect arguments about why animals might have evolved ‘target of resveratrol' for their benefit (in agreement with the xenohormesis model)... environment, when animals live long enough to experience aging, the aging suppressant side effect becomes apparent.

Show MeSH