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Inhibition of S6K by resveratrol: in search of the purpose.

Blagosklonny MV - Aging (Albany NY) (2009)

View Article: PubMed Central - PubMed

Affiliation: Department of Cell Stress Biology, Roswell Park Cancer Institute, Buffalo, NY 14263, USA. Blagosklonny@oncotarget.com

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Resveratrol, a natural agent found in grape skins, has been proposed to account for the beneficial effects of red wine against heart disease... Resveratrol prevents age-related diseases and extends lifespan in several species... In response to nutrients, growth factors and hormones, the mTOR/S6K pathway promotes cellular mass growth, which is needed for cell proliferation... Given that the nutrient-sensing TOR/S6K pathway promotes cellular growth, plants produce resveratrol to inhibit fungal growth, thus protecting the grape... In a recent issue of Aging, Michael Hall and I discussed how growth and aging are hardwired that suppression of growth also suppresses aging... Plants, microorganisms and sea animals produce toxic agents that inhibit or damage microtubules, DNA, heat-shock proteins, deacetylases and the proteasome, for example... These cytotoxic agents are used as anti-cancer drugs, although nature did not create them for that purpose... Although not created for that purpose by nature, inhibitors of mTOR are used as anticancer agents... Furthermore, rapamycin prevents cancer in humans, perhaps, as an ‘anti-aging side effect'... Rapamycin is also indicated for the therapy of almost all age-related diseases from atherosclerosis to macular degeneration... This is consistent with there being multiple targets for resveratrol exactly in the pathway that senses the environment... Second, according to the anti-aging side effect model, plants and bacteria produce growth suppressants to hurt parasites and competitors... In the wild, growth suppressants exclusively hurt young organisms by inhibiting their developmental growth... In the protected environment, when animals live long enough to experience aging, the aging suppressant side effect becomes apparent.

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The nutrient-sensing pathway as a target of resveratrol.In red, targets                                            that are inhibited by resveratrol. In green, targets that are activated by                                            resveratrol.
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Figure 1: The nutrient-sensing pathway as a target of resveratrol.In red, targets that are inhibited by resveratrol. In green, targets that are activated by resveratrol.

Mentions: In addition, resveratrol activates sirtuins [2,24-25] and AMPK [6,26], which may antagonize the TOR pathway downstream and upstream, respectively (Figure 1). It has been suggested that sirtuins and mTOR may be involved in the same longevity pathway [27]. By inhibiting S6K and activating sirtuins, resverat- rol may exert its anti-aging effect. But why would plants produce an anti-aging drug?


Inhibition of S6K by resveratrol: in search of the purpose.

Blagosklonny MV - Aging (Albany NY) (2009)

The nutrient-sensing pathway as a target of resveratrol.In red, targets                                            that are inhibited by resveratrol. In green, targets that are activated by                                            resveratrol.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC2806036&req=5

Figure 1: The nutrient-sensing pathway as a target of resveratrol.In red, targets that are inhibited by resveratrol. In green, targets that are activated by resveratrol.
Mentions: In addition, resveratrol activates sirtuins [2,24-25] and AMPK [6,26], which may antagonize the TOR pathway downstream and upstream, respectively (Figure 1). It has been suggested that sirtuins and mTOR may be involved in the same longevity pathway [27]. By inhibiting S6K and activating sirtuins, resverat- rol may exert its anti-aging effect. But why would plants produce an anti-aging drug?

View Article: PubMed Central - PubMed

Affiliation: Department of Cell Stress Biology, Roswell Park Cancer Institute, Buffalo, NY 14263, USA. Blagosklonny@oncotarget.com

AUTOMATICALLY GENERATED EXCERPT
Please rate it.

Resveratrol, a natural agent found in grape skins, has been proposed to account for the beneficial effects of red wine against heart disease... Resveratrol prevents age-related diseases and extends lifespan in several species... In response to nutrients, growth factors and hormones, the mTOR/S6K pathway promotes cellular mass growth, which is needed for cell proliferation... Given that the nutrient-sensing TOR/S6K pathway promotes cellular growth, plants produce resveratrol to inhibit fungal growth, thus protecting the grape... In a recent issue of Aging, Michael Hall and I discussed how growth and aging are hardwired that suppression of growth also suppresses aging... Plants, microorganisms and sea animals produce toxic agents that inhibit or damage microtubules, DNA, heat-shock proteins, deacetylases and the proteasome, for example... These cytotoxic agents are used as anti-cancer drugs, although nature did not create them for that purpose... Although not created for that purpose by nature, inhibitors of mTOR are used as anticancer agents... Furthermore, rapamycin prevents cancer in humans, perhaps, as an ‘anti-aging side effect'... Rapamycin is also indicated for the therapy of almost all age-related diseases from atherosclerosis to macular degeneration... This is consistent with there being multiple targets for resveratrol exactly in the pathway that senses the environment... Second, according to the anti-aging side effect model, plants and bacteria produce growth suppressants to hurt parasites and competitors... In the wild, growth suppressants exclusively hurt young organisms by inhibiting their developmental growth... In the protected environment, when animals live long enough to experience aging, the aging suppressant side effect becomes apparent.

Show MeSH