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Risk stratification for sudden cardiac death: current approaches and predictive value.

Lopera G, Curtis AB - Curr Cardiol Rev (2009)

Bottom Line: Current risk stratification strategies fail to identify patients at risk of SCD in larger population groups encompassing a greater number of potential SCD victims.However, the best approach to identifying patients and the value of various risk stratification tools is not entirely clear.The goal of this review is to discuss the problem of SCD and the value of the different risk stratification markers and their potential clinical use either alone or in combination with other risk stratification markers.

View Article: PubMed Central - PubMed

Affiliation: Division of Cardiology, University of Miami/Miller School of Medicine, Miami, FL, USA.

ABSTRACT
Sudden cardiac death (SCD) is a serious public health problem; the annual incidence of out-of-hospital cardiac arrest in North America is approximately 166,200. Identifying patients at risk is a difficult proposition. At the present time, left ventricular ejection fraction (LVEF) remains the single most important marker for risk stratification. According to current guidelines, most patients with LVEF <35% could benefit from prophylactic ICD implantation, particularly in the setting of symptomatic heart failure. Current risk stratification strategies fail to identify patients at risk of SCD in larger population groups encompassing a greater number of potential SCD victims. However, the best approach to identifying patients and the value of various risk stratification tools is not entirely clear. The goal of this review is to discuss the problem of SCD and the value of the different risk stratification markers and their potential clinical use either alone or in combination with other risk stratification markers.

No MeSH data available.


Related in: MedlinePlus

Results from clinical trials showing incremental decreases in mortality when added onto previous therapy. (Reprinted with permission Elsevier Limited).
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Figure 1: Results from clinical trials showing incremental decreases in mortality when added onto previous therapy. (Reprinted with permission Elsevier Limited).

Mentions: Primary prevention trials of ICD therapy have established depressed left ventricular ejection fraction (LVEF) as the single most important risk stratification tool to identify individuals with a high risk of SCD [3-5]. In these trials, ICD therapy has provided an additional one-third incremental protection against all-cause mortality and SCD to the benefit obtained with optimal heart failure therapy alone [6] (Fig. 1).


Risk stratification for sudden cardiac death: current approaches and predictive value.

Lopera G, Curtis AB - Curr Cardiol Rev (2009)

Results from clinical trials showing incremental decreases in mortality when added onto previous therapy. (Reprinted with permission Elsevier Limited).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC2803290&req=5

Figure 1: Results from clinical trials showing incremental decreases in mortality when added onto previous therapy. (Reprinted with permission Elsevier Limited).
Mentions: Primary prevention trials of ICD therapy have established depressed left ventricular ejection fraction (LVEF) as the single most important risk stratification tool to identify individuals with a high risk of SCD [3-5]. In these trials, ICD therapy has provided an additional one-third incremental protection against all-cause mortality and SCD to the benefit obtained with optimal heart failure therapy alone [6] (Fig. 1).

Bottom Line: Current risk stratification strategies fail to identify patients at risk of SCD in larger population groups encompassing a greater number of potential SCD victims.However, the best approach to identifying patients and the value of various risk stratification tools is not entirely clear.The goal of this review is to discuss the problem of SCD and the value of the different risk stratification markers and their potential clinical use either alone or in combination with other risk stratification markers.

View Article: PubMed Central - PubMed

Affiliation: Division of Cardiology, University of Miami/Miller School of Medicine, Miami, FL, USA.

ABSTRACT
Sudden cardiac death (SCD) is a serious public health problem; the annual incidence of out-of-hospital cardiac arrest in North America is approximately 166,200. Identifying patients at risk is a difficult proposition. At the present time, left ventricular ejection fraction (LVEF) remains the single most important marker for risk stratification. According to current guidelines, most patients with LVEF <35% could benefit from prophylactic ICD implantation, particularly in the setting of symptomatic heart failure. Current risk stratification strategies fail to identify patients at risk of SCD in larger population groups encompassing a greater number of potential SCD victims. However, the best approach to identifying patients and the value of various risk stratification tools is not entirely clear. The goal of this review is to discuss the problem of SCD and the value of the different risk stratification markers and their potential clinical use either alone or in combination with other risk stratification markers.

No MeSH data available.


Related in: MedlinePlus