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Print-and-peel fabrication for microfluidics: what's in it for biomedical applications?

Thomas MS, Millare B, Clift JM, Bao D, Hong C, Vullev VI - Ann Biomed Eng (2009)

Bottom Line: Microfluidics have, indeed, proven to be an indispensable toolkit for biological and biomedical research and development.Through accessibility to such methodologies for relatively fast and easy prototyping, PAP has the potential to considerably accelerate the impacts of microfluidics on the biological sciences and engineering.Comparative discussions of the different PAP techniques, along with the current challenges and approaches for addressing them, outline the perspectives for PAP and how it can be readily adopted by a broad range of scientists and engineers.

View Article: PubMed Central - PubMed

Affiliation: Department of Bioengineering, University of California, Riverside, CA 92521, USA.

ABSTRACT
This article reviews the development and the advances of print-and-peel (PAP) microfabrication. PAP techniques provide means for facile and expedient prototyping of microfluidic devices. Therefore, PAP has the potential for broadening the microfluidics technology by bringing it to researchers who lack regular or any accesses to specialized fabrication facilities and equipment. Microfluidics have, indeed, proven to be an indispensable toolkit for biological and biomedical research and development. Through accessibility to such methodologies for relatively fast and easy prototyping, PAP has the potential to considerably accelerate the impacts of microfluidics on the biological sciences and engineering. In summary, PAP encompasses: (1) direct printing of the masters for casting polymer device components; and (2) adding three-dimensional elements onto the masters for single-molding-step formation of channels and cavities within the bulk of the polymer slabs. Comparative discussions of the different PAP techniques, along with the current challenges and approaches for addressing them, outline the perspectives for PAP and how it can be readily adopted by a broad range of scientists and engineers.

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Related in: MedlinePlus

Microscope images of: (a, c, e) horizontal lines printed with a LaserJet printer (HP 1320); and (b, d, f) the corresponding PDMS replica of the printed lines. The printed features are reproduction of CAD (FreeHand, v. 10) images with line thickness: (a, b) 200 μm; (c, d) 100 μm; and (e, f) 20 μm. The scale bars correspond to 100 μm
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Fig3: Microscope images of: (a, c, e) horizontal lines printed with a LaserJet printer (HP 1320); and (b, d, f) the corresponding PDMS replica of the printed lines. The printed features are reproduction of CAD (FreeHand, v. 10) images with line thickness: (a, b) 200 μm; (c, d) 100 μm; and (e, f) 20 μm. The scale bars correspond to 100 μm

Mentions: Solid-ink (wax) printers present an alternative to LaserJet printers for PAP applications.33,35 The solid-ink printers have the principle advantage for generating features with improved smoothness (Fig. 2), while the granular structure of the LaserJet toners is quite conspicuous on the produced PDMS replicas (Fig. 3). The relatively low melting point of the waxy solid ink, however, prevents the cast PDMS from curing at elevated temperature.Figure 2


Print-and-peel fabrication for microfluidics: what's in it for biomedical applications?

Thomas MS, Millare B, Clift JM, Bao D, Hong C, Vullev VI - Ann Biomed Eng (2009)

Microscope images of: (a, c, e) horizontal lines printed with a LaserJet printer (HP 1320); and (b, d, f) the corresponding PDMS replica of the printed lines. The printed features are reproduction of CAD (FreeHand, v. 10) images with line thickness: (a, b) 200 μm; (c, d) 100 μm; and (e, f) 20 μm. The scale bars correspond to 100 μm
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC2803264&req=5

Fig3: Microscope images of: (a, c, e) horizontal lines printed with a LaserJet printer (HP 1320); and (b, d, f) the corresponding PDMS replica of the printed lines. The printed features are reproduction of CAD (FreeHand, v. 10) images with line thickness: (a, b) 200 μm; (c, d) 100 μm; and (e, f) 20 μm. The scale bars correspond to 100 μm
Mentions: Solid-ink (wax) printers present an alternative to LaserJet printers for PAP applications.33,35 The solid-ink printers have the principle advantage for generating features with improved smoothness (Fig. 2), while the granular structure of the LaserJet toners is quite conspicuous on the produced PDMS replicas (Fig. 3). The relatively low melting point of the waxy solid ink, however, prevents the cast PDMS from curing at elevated temperature.Figure 2

Bottom Line: Microfluidics have, indeed, proven to be an indispensable toolkit for biological and biomedical research and development.Through accessibility to such methodologies for relatively fast and easy prototyping, PAP has the potential to considerably accelerate the impacts of microfluidics on the biological sciences and engineering.Comparative discussions of the different PAP techniques, along with the current challenges and approaches for addressing them, outline the perspectives for PAP and how it can be readily adopted by a broad range of scientists and engineers.

View Article: PubMed Central - PubMed

Affiliation: Department of Bioengineering, University of California, Riverside, CA 92521, USA.

ABSTRACT
This article reviews the development and the advances of print-and-peel (PAP) microfabrication. PAP techniques provide means for facile and expedient prototyping of microfluidic devices. Therefore, PAP has the potential for broadening the microfluidics technology by bringing it to researchers who lack regular or any accesses to specialized fabrication facilities and equipment. Microfluidics have, indeed, proven to be an indispensable toolkit for biological and biomedical research and development. Through accessibility to such methodologies for relatively fast and easy prototyping, PAP has the potential to considerably accelerate the impacts of microfluidics on the biological sciences and engineering. In summary, PAP encompasses: (1) direct printing of the masters for casting polymer device components; and (2) adding three-dimensional elements onto the masters for single-molding-step formation of channels and cavities within the bulk of the polymer slabs. Comparative discussions of the different PAP techniques, along with the current challenges and approaches for addressing them, outline the perspectives for PAP and how it can be readily adopted by a broad range of scientists and engineers.

Show MeSH
Related in: MedlinePlus