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Energy metabolism in Japanese patients with Crohn's disease.

Sasaki M, Johtatsu T, Kurihara M, Iwakawa H, Tanaka T, Tsujikawa T, Fujiyama Y, Andoh A - J Clin Biochem Nutr (2009)

Bottom Line: The mREEs in CD patients were significantly higher than those of healthy controls (24.4 +/- 2.4 kcal/kg/day vs 21.3 +/- 1.7 kcal/kg/day).However, mREEs in CD patients were significantly lower than predicted REEs (pREEs) calculated by the Harris-Benedict equation (26.4 +/- 2.5 kcal/kg/day).CD patients had hyper-metabolic statuses evaluated by mREE/body weight, but increased energy expenditure did not contribute to weight loss in these patients.

View Article: PubMed Central - PubMed

Affiliation: Division of Clinical Nutrition, Shiga University of Medical Science, Seta-Tsukinowa, Otsu 520-2192, Japan.

ABSTRACT
We investigated energy expenditure in hospitalized patients with Crohn's disease (CD), and determined optimal energy requirements for nutritional therapy. Sixteen patients (5 women and 11 men, mean age 36 year old, mean BMI 18.7 kg/m(2)) and 8 healthy volunteers were enrolled in this study. Measured resting energy expenditure (mREE) levels were determined by indirect calorimetry. The mREEs in CD patients were significantly higher than those of healthy controls (24.4 +/- 2.4 kcal/kg/day vs 21.3 +/- 1.7 kcal/kg/day). However, mREEs in CD patients were significantly lower than predicted REEs (pREEs) calculated by the Harris-Benedict equation (26.4 +/- 2.5 kcal/kg/day). Furthermore, mREE/pREE values were lower in undernourished patients than in well-nourished patients. CD patients had hyper-metabolic statuses evaluated by mREE/body weight, but increased energy expenditure did not contribute to weight loss in these patients. In conclusion, nutritional therapy with 25-30 kcal/ideal body weight/day (calculated by mREE x active factor) may be optimal for active CD patients, while higher energy intake values pose the risk of overfeeding.

No MeSH data available.


Related in: MedlinePlus

Comparison of resting energy expenditure measured by using indirect calorimetry (mREE) and predicted resting energy expenditure (pREE) calculated by Harris-Benedict equation in CD patients (n = 16). mREE is significantly lower than pREE in CD patients.
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Related In: Results  -  Collection


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Figure 2: Comparison of resting energy expenditure measured by using indirect calorimetry (mREE) and predicted resting energy expenditure (pREE) calculated by Harris-Benedict equation in CD patients (n = 16). mREE is significantly lower than pREE in CD patients.

Mentions: In CD patients, mREE/body weight was significantly lower than pREE/body weight (26.4 ± 2.5 kcal/kg/day) (Fig. 2). Percentage of mREE/pREE was 93.6 ± 13.7% in CD patients. In only two patients, mREE/body weight was higher than pBEE/body weight, and one of them developed complications including an abdominal abscess with fever.


Energy metabolism in Japanese patients with Crohn's disease.

Sasaki M, Johtatsu T, Kurihara M, Iwakawa H, Tanaka T, Tsujikawa T, Fujiyama Y, Andoh A - J Clin Biochem Nutr (2009)

Comparison of resting energy expenditure measured by using indirect calorimetry (mREE) and predicted resting energy expenditure (pREE) calculated by Harris-Benedict equation in CD patients (n = 16). mREE is significantly lower than pREE in CD patients.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC2803135&req=5

Figure 2: Comparison of resting energy expenditure measured by using indirect calorimetry (mREE) and predicted resting energy expenditure (pREE) calculated by Harris-Benedict equation in CD patients (n = 16). mREE is significantly lower than pREE in CD patients.
Mentions: In CD patients, mREE/body weight was significantly lower than pREE/body weight (26.4 ± 2.5 kcal/kg/day) (Fig. 2). Percentage of mREE/pREE was 93.6 ± 13.7% in CD patients. In only two patients, mREE/body weight was higher than pBEE/body weight, and one of them developed complications including an abdominal abscess with fever.

Bottom Line: The mREEs in CD patients were significantly higher than those of healthy controls (24.4 +/- 2.4 kcal/kg/day vs 21.3 +/- 1.7 kcal/kg/day).However, mREEs in CD patients were significantly lower than predicted REEs (pREEs) calculated by the Harris-Benedict equation (26.4 +/- 2.5 kcal/kg/day).CD patients had hyper-metabolic statuses evaluated by mREE/body weight, but increased energy expenditure did not contribute to weight loss in these patients.

View Article: PubMed Central - PubMed

Affiliation: Division of Clinical Nutrition, Shiga University of Medical Science, Seta-Tsukinowa, Otsu 520-2192, Japan.

ABSTRACT
We investigated energy expenditure in hospitalized patients with Crohn's disease (CD), and determined optimal energy requirements for nutritional therapy. Sixteen patients (5 women and 11 men, mean age 36 year old, mean BMI 18.7 kg/m(2)) and 8 healthy volunteers were enrolled in this study. Measured resting energy expenditure (mREE) levels were determined by indirect calorimetry. The mREEs in CD patients were significantly higher than those of healthy controls (24.4 +/- 2.4 kcal/kg/day vs 21.3 +/- 1.7 kcal/kg/day). However, mREEs in CD patients were significantly lower than predicted REEs (pREEs) calculated by the Harris-Benedict equation (26.4 +/- 2.5 kcal/kg/day). Furthermore, mREE/pREE values were lower in undernourished patients than in well-nourished patients. CD patients had hyper-metabolic statuses evaluated by mREE/body weight, but increased energy expenditure did not contribute to weight loss in these patients. In conclusion, nutritional therapy with 25-30 kcal/ideal body weight/day (calculated by mREE x active factor) may be optimal for active CD patients, while higher energy intake values pose the risk of overfeeding.

No MeSH data available.


Related in: MedlinePlus