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The effect of doxycycline on canine hip osteoarthritis: design of a 6-months clinical trial.

Nganvongpanit K, Pothacharoen P, Suwankong N, Ong-Chai S, Kongtawelert P - J. Vet. Sci. (2009)

Bottom Line: The assessment protocol included clinical score, radiographic findings and serum osteoarthritis biomarkers.Biomarker levels of CS-WF6 epitope and hyaluronan were significantly increased and decreased (p < 0.05) at 2 and 3 months after treatment compared to pretreatment.These results showed that DOX had a positive therapeutic effect in dogs with osteoarthritis.

View Article: PubMed Central - PubMed

Affiliation: Bone and Joint Research Laboratory, Department of Veterinary Biosciences and Public Health, Faculty of Veterinary Medicine, Chiang Mai University, Chiang Mai 50100, Thailand. korakot@chiangmai.ac.th

ABSTRACT
Twenty-five dogs were included in a randomized, double-blind trial to assess the efficacy of doxycycline (DOX) orally administered twice a day at 4 mg/kg/day (n = 12) for the treatment of osteoarthritis of the hip. Chondroitin sulfate (CS; 525 mg/day) was used as a positive control (n = 13). Dogs were re-examined monthly for 6 months after initiation of treatment. The assessment protocol included clinical score, radiographic findings and serum osteoarthritis biomarkers. Dogs treated with DOX showed statistically significant improvements (p < 0.05) in lameness, joint mobility, pain on palpation, weight-bearing and overall score at 2, 6, 4, 4 and 4 months, respectively, after treatment. Biomarker levels of CS-WF6 epitope and hyaluronan were significantly increased and decreased (p < 0.05) at 2 and 3 months after treatment compared to pretreatment. These results showed that DOX had a positive therapeutic effect in dogs with osteoarthritis.

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Related in: MedlinePlus

Mean radiography scores. Black = DOX group; white = CS group. Vertical bar means a standard deviation.
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Figure 2: Mean radiography scores. Black = DOX group; white = CS group. Vertical bar means a standard deviation.

Mentions: Radiography scores are shown in Fig. 2. Those scores were not significantly difference between treatment groups (p > 0.05). When comparing with the pretreatment scores, there also was no significant difference (p < 0.05).


The effect of doxycycline on canine hip osteoarthritis: design of a 6-months clinical trial.

Nganvongpanit K, Pothacharoen P, Suwankong N, Ong-Chai S, Kongtawelert P - J. Vet. Sci. (2009)

Mean radiography scores. Black = DOX group; white = CS group. Vertical bar means a standard deviation.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC2801128&req=5

Figure 2: Mean radiography scores. Black = DOX group; white = CS group. Vertical bar means a standard deviation.
Mentions: Radiography scores are shown in Fig. 2. Those scores were not significantly difference between treatment groups (p > 0.05). When comparing with the pretreatment scores, there also was no significant difference (p < 0.05).

Bottom Line: The assessment protocol included clinical score, radiographic findings and serum osteoarthritis biomarkers.Biomarker levels of CS-WF6 epitope and hyaluronan were significantly increased and decreased (p < 0.05) at 2 and 3 months after treatment compared to pretreatment.These results showed that DOX had a positive therapeutic effect in dogs with osteoarthritis.

View Article: PubMed Central - PubMed

Affiliation: Bone and Joint Research Laboratory, Department of Veterinary Biosciences and Public Health, Faculty of Veterinary Medicine, Chiang Mai University, Chiang Mai 50100, Thailand. korakot@chiangmai.ac.th

ABSTRACT
Twenty-five dogs were included in a randomized, double-blind trial to assess the efficacy of doxycycline (DOX) orally administered twice a day at 4 mg/kg/day (n = 12) for the treatment of osteoarthritis of the hip. Chondroitin sulfate (CS; 525 mg/day) was used as a positive control (n = 13). Dogs were re-examined monthly for 6 months after initiation of treatment. The assessment protocol included clinical score, radiographic findings and serum osteoarthritis biomarkers. Dogs treated with DOX showed statistically significant improvements (p < 0.05) in lameness, joint mobility, pain on palpation, weight-bearing and overall score at 2, 6, 4, 4 and 4 months, respectively, after treatment. Biomarker levels of CS-WF6 epitope and hyaluronan were significantly increased and decreased (p < 0.05) at 2 and 3 months after treatment compared to pretreatment. These results showed that DOX had a positive therapeutic effect in dogs with osteoarthritis.

Show MeSH
Related in: MedlinePlus