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Anti-obesity activity of diglyceride containing conjugated linoleic acid in C57BL/6J ob/ob mice.

Hue JJ, Lee KN, Jeong JH, Lee SH, Lee YH, Jeong SW, Nam SY, Yun YW, Lee BJ - J. Vet. Sci. (2009)

Bottom Line: The levels of total cholesterol were also significantly reduced in DG and DG-CLA groups compared with the control group (p < 0.05).CLA significantly decreased weights of renal and epididymal fats compared with the control (p < 0.05).DG and DGCLA also significantly decreased the epididymal fat weights compared with the control (p < 0.05).

View Article: PubMed Central - PubMed

Affiliation: College of Veterinary Medicine and Research Institute of Veterinary Medicine, Chungbuk National University, Cheongju 361-763, Korea.

ABSTRACT
This study was to investigate the anti-obesity effects of diglyceride (DG)-conjugated linoleic acid (CLA) containing 22% CLA as fatty acids in C57BL/6J ob/ob male mice. There were four experimental groups including vehicle control, DG, CLA, and DG-CLA. The test solutions of 750 mg/kg dose were orally administered to the mice everyday for 5 weeks. CLA treatments significantly decreased mean body weight in the obese mice throughout the experimental period compared to the control (p < 0.01). All test solutions significantly decreased the levels of triglyceride, glucose and free fatty acids in the serum compared with control (p < 0.05). The levels of total cholesterol were also significantly reduced in DG and DG-CLA groups compared with the control group (p < 0.05). CLA significantly decreased weights of renal and epididymal fats compared with the control (p < 0.05). DG and DGCLA also significantly decreased the epididymal fat weights compared with the control (p < 0.05). A remarkable decrease in the number of lipid droplets and fat globules was observed in the livers of mice treated with DG, CLA, and DG-CLA compared to control. Treatments of DG and CLA actually increased the expression of peroxisome proliferator-activated receptor gamma. These results suggest that DG-CLA containing 22% CLA have a respectable anti-obesity effect by controlling serum lipids and fat metabolism.

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Change in body weights of C57BL/6J ob/ob male mice for 5 weeks. DG: diglyceride, CLA: conjugated linoleic acid, DG-CLA: DG containing 22% CLA as fatty acid. Data is expressed as the means ± SE (n = 10). *Significantly different from the control at p < 0.01.
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Figure 1: Change in body weights of C57BL/6J ob/ob male mice for 5 weeks. DG: diglyceride, CLA: conjugated linoleic acid, DG-CLA: DG containing 22% CLA as fatty acid. Data is expressed as the means ± SE (n = 10). *Significantly different from the control at p < 0.01.

Mentions: CLA treatment significantly decreased the mean body weights in the obese mice throughout the experimental periods compared with the control (Fig. 1) (p < 0.01). Meanwhile, treatments of DG or DG-CLA did not significantly decrease the mean body weight compared to control (Fig. 1). The decrease in body weight by CLA was also significantly different from the DG or DG-CLA groups (p < 0.05). The daily feed intake for the experimental period in the CLA group was significantly lower than the control and DG groups (Fig. 2) (p < 0.01). The reduction of body weight was strongly associated with the decrease in food consumption of the obese mice.


Anti-obesity activity of diglyceride containing conjugated linoleic acid in C57BL/6J ob/ob mice.

Hue JJ, Lee KN, Jeong JH, Lee SH, Lee YH, Jeong SW, Nam SY, Yun YW, Lee BJ - J. Vet. Sci. (2009)

Change in body weights of C57BL/6J ob/ob male mice for 5 weeks. DG: diglyceride, CLA: conjugated linoleic acid, DG-CLA: DG containing 22% CLA as fatty acid. Data is expressed as the means ± SE (n = 10). *Significantly different from the control at p < 0.01.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC2801123&req=5

Figure 1: Change in body weights of C57BL/6J ob/ob male mice for 5 weeks. DG: diglyceride, CLA: conjugated linoleic acid, DG-CLA: DG containing 22% CLA as fatty acid. Data is expressed as the means ± SE (n = 10). *Significantly different from the control at p < 0.01.
Mentions: CLA treatment significantly decreased the mean body weights in the obese mice throughout the experimental periods compared with the control (Fig. 1) (p < 0.01). Meanwhile, treatments of DG or DG-CLA did not significantly decrease the mean body weight compared to control (Fig. 1). The decrease in body weight by CLA was also significantly different from the DG or DG-CLA groups (p < 0.05). The daily feed intake for the experimental period in the CLA group was significantly lower than the control and DG groups (Fig. 2) (p < 0.01). The reduction of body weight was strongly associated with the decrease in food consumption of the obese mice.

Bottom Line: The levels of total cholesterol were also significantly reduced in DG and DG-CLA groups compared with the control group (p < 0.05).CLA significantly decreased weights of renal and epididymal fats compared with the control (p < 0.05).DG and DGCLA also significantly decreased the epididymal fat weights compared with the control (p < 0.05).

View Article: PubMed Central - PubMed

Affiliation: College of Veterinary Medicine and Research Institute of Veterinary Medicine, Chungbuk National University, Cheongju 361-763, Korea.

ABSTRACT
This study was to investigate the anti-obesity effects of diglyceride (DG)-conjugated linoleic acid (CLA) containing 22% CLA as fatty acids in C57BL/6J ob/ob male mice. There were four experimental groups including vehicle control, DG, CLA, and DG-CLA. The test solutions of 750 mg/kg dose were orally administered to the mice everyday for 5 weeks. CLA treatments significantly decreased mean body weight in the obese mice throughout the experimental period compared to the control (p < 0.01). All test solutions significantly decreased the levels of triglyceride, glucose and free fatty acids in the serum compared with control (p < 0.05). The levels of total cholesterol were also significantly reduced in DG and DG-CLA groups compared with the control group (p < 0.05). CLA significantly decreased weights of renal and epididymal fats compared with the control (p < 0.05). DG and DGCLA also significantly decreased the epididymal fat weights compared with the control (p < 0.05). A remarkable decrease in the number of lipid droplets and fat globules was observed in the livers of mice treated with DG, CLA, and DG-CLA compared to control. Treatments of DG and CLA actually increased the expression of peroxisome proliferator-activated receptor gamma. These results suggest that DG-CLA containing 22% CLA have a respectable anti-obesity effect by controlling serum lipids and fat metabolism.

Show MeSH
Related in: MedlinePlus