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Porcine abortion outbreak associated with Toxoplasma gondii in Jeju Island, Korea.

Kim JH, Kang KI, Kang WC, Sohn HJ, Jean YH, Park BK, Kim Y, Kim DY - J. Vet. Sci. (2009)

Bottom Line: Tachyzoites of Toxoplasma (T.) gondii were detected immunohistochemically.The disease outbreak in this herd was diagnosed as epizootic toxoplasmosis.To our knowledge, this is the first report of porcine toxoplasmosis with a high abortion rate and sow mortality in Korea.

View Article: PubMed Central - PubMed

Affiliation: College of Veterinary Medicine, Jeju National University, Jeju, Korea. kimjhoon@jejunu.ac.kr

ABSTRACT
This report deals with the acute onset of an abortion outbreak and high sow mortality in one pig herd consisted of 1,200 pigs and 120 sows on Jeju Island, Korea. Affected pregnant sows showed clinical signs, including high fever, gradual anorexia, vomiting, depression, recumbency, prostration, abortion, and a few deaths. Four dead sows, five aborted fetuses from the same litter, and 17 sera collected from sows infected or normal were submitted to the Pathology Division of the National Veterinary Research and Quarantine Service for diagnostic investigation. Grossly, hepatomegaly and splenomegaly were observed in sows. Multiple necrotic foci were scattered in the lungs, liver, spleen, and lymph nodes. Microscopically, multifocal necrotizing lesions and protozoan tachyzoites were present in the lesions. Tachyzoites of Toxoplasma (T.) gondii were detected immunohistochemically. Latex agglutination showed that the sera of 7 of 17 (41.2%) sows were positive for antibody to T. gondii. The disease outbreak in this herd was diagnosed as epizootic toxoplasmosis. To our knowledge, this is the first report of porcine toxoplasmosis with a high abortion rate and sow mortality in Korea.

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Liver of aborted sow, showing multifocal necrotic hepatitis. H&E, ×200. Insert: Note brown tachyzoites of Toxoplasma gondii in sinusoid and Kupffer cell. ABC stain, ×400.
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Figure 1: Liver of aborted sow, showing multifocal necrotic hepatitis. H&E, ×200. Insert: Note brown tachyzoites of Toxoplasma gondii in sinusoid and Kupffer cell. ABC stain, ×400.

Mentions: Microscopically, moderate multifocal necrotizing pneumonia with intralesional protozoan tachyzoites was present in the lungs of sows. Mild perivascular or peribronchiolar lymphoid cuffings associated with mycoplasmal pneumonia were observed in two sows. Severe multifocal necrotizing granulomatous cholangiohepatitis, characterized by the infiltration of lymphocytes, plasma cells, macrophages and a few neutrophils and protozoan tachyzoites, were observed in the livers (Fig. 1). The lymph nodes presented with severe lymphadenitis, with focal to diffuse necrosis and protozoan tachyzoites, and the spleens showed moderate congestion, lymphoid depletion and multifocal necrosis. Lymphohistiocytic meningoencephalitis with disseminated malacic foci and perivascular cuffing was observed in the brains (Fig. 2).


Porcine abortion outbreak associated with Toxoplasma gondii in Jeju Island, Korea.

Kim JH, Kang KI, Kang WC, Sohn HJ, Jean YH, Park BK, Kim Y, Kim DY - J. Vet. Sci. (2009)

Liver of aborted sow, showing multifocal necrotic hepatitis. H&E, ×200. Insert: Note brown tachyzoites of Toxoplasma gondii in sinusoid and Kupffer cell. ABC stain, ×400.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC2801119&req=5

Figure 1: Liver of aborted sow, showing multifocal necrotic hepatitis. H&E, ×200. Insert: Note brown tachyzoites of Toxoplasma gondii in sinusoid and Kupffer cell. ABC stain, ×400.
Mentions: Microscopically, moderate multifocal necrotizing pneumonia with intralesional protozoan tachyzoites was present in the lungs of sows. Mild perivascular or peribronchiolar lymphoid cuffings associated with mycoplasmal pneumonia were observed in two sows. Severe multifocal necrotizing granulomatous cholangiohepatitis, characterized by the infiltration of lymphocytes, plasma cells, macrophages and a few neutrophils and protozoan tachyzoites, were observed in the livers (Fig. 1). The lymph nodes presented with severe lymphadenitis, with focal to diffuse necrosis and protozoan tachyzoites, and the spleens showed moderate congestion, lymphoid depletion and multifocal necrosis. Lymphohistiocytic meningoencephalitis with disseminated malacic foci and perivascular cuffing was observed in the brains (Fig. 2).

Bottom Line: Tachyzoites of Toxoplasma (T.) gondii were detected immunohistochemically.The disease outbreak in this herd was diagnosed as epizootic toxoplasmosis.To our knowledge, this is the first report of porcine toxoplasmosis with a high abortion rate and sow mortality in Korea.

View Article: PubMed Central - PubMed

Affiliation: College of Veterinary Medicine, Jeju National University, Jeju, Korea. kimjhoon@jejunu.ac.kr

ABSTRACT
This report deals with the acute onset of an abortion outbreak and high sow mortality in one pig herd consisted of 1,200 pigs and 120 sows on Jeju Island, Korea. Affected pregnant sows showed clinical signs, including high fever, gradual anorexia, vomiting, depression, recumbency, prostration, abortion, and a few deaths. Four dead sows, five aborted fetuses from the same litter, and 17 sera collected from sows infected or normal were submitted to the Pathology Division of the National Veterinary Research and Quarantine Service for diagnostic investigation. Grossly, hepatomegaly and splenomegaly were observed in sows. Multiple necrotic foci were scattered in the lungs, liver, spleen, and lymph nodes. Microscopically, multifocal necrotizing lesions and protozoan tachyzoites were present in the lesions. Tachyzoites of Toxoplasma (T.) gondii were detected immunohistochemically. Latex agglutination showed that the sera of 7 of 17 (41.2%) sows were positive for antibody to T. gondii. The disease outbreak in this herd was diagnosed as epizootic toxoplasmosis. To our knowledge, this is the first report of porcine toxoplasmosis with a high abortion rate and sow mortality in Korea.

Show MeSH
Related in: MedlinePlus