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Imaging evaluation of the liver using multi-detector row computed tomography in micropigs as potential living liver donors.

Ryu JM, Kim DH, Lee MY, Lee SH, Park JH, Yun SP, Jang MW, Kim SH, Rho GJ, Han HJ - J. Vet. Sci. (2009)

Bottom Line: The diameters of the common hepatic artery and proper hepatic artery were 6.24 +/- 0.20 mm and 4.68 +/- 0.13 mm, respectively.The hepatic vascular system of the micropigs was similar to that of humans, except for the variation in the length of the proper hepatic artery.In addition, the diameter of the portal vein was 11.27 +/- 0.38 mm.

View Article: PubMed Central - PubMed

Affiliation: Department of Veterinary Physiology, College of Veterinary Medicine, Biotherapy Human Resources Center (BK21), Chonnam National University, Gwangju, Korea.

ABSTRACT
The shortage of organ donors has stimulated interest in the possibility of using animal organs for transplantation into humans. In addition, pigs are now considered to be the most likely source animals for human xenotransplantation because of their advantages over non-human primates. However, the appropriate standard values for estimations of the liver of micropigs have not been established. The determination of standard values for the micropig liver using multi-detector row computed tomography (MDCT) would help to select a suitable donor for an individual patient, determine the condition of the liver of the micropigs and help predict patient prognosis. Therefore, we determined the standard values for the livers of micropigs using MDCT. The liver parenchyma showed homogenous enhancement and had no space-occupying lesions. The total and right lobe volumes of the liver were 698.57 +/- 47.81 ml and 420.14 +/- 26.70 ml, which are 51.74% and 49.35% of the human liver volume, respectively. In micropigs, the percentage of liver volume to body weight was approximately 2.05%. The diameters of the common hepatic artery and proper hepatic artery were 6.24 +/- 0.20 mm and 4.68 +/- 0.13 mm, respectively. The hepatic vascular system of the micropigs was similar to that of humans, except for the variation in the length of the proper hepatic artery. In addition, the diameter of the portal vein was 11.27 +/- 0.38 mm. In conclusion, imaging evaluation using the MDCT was a reliable method for liver evaluation and its vascular anatomy for xenotransplantation using micropigs.

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Three-dimensional volume rendered image of hepatic vascular system (A) and magnified image of the area demarcated by the white dotted rectangle (B). [Celiac axis (black arrow), splenic artery (white arrow), gastroduodenal artery (small white arrow), left gastric artery (small black arrow), common hepatic artery (black arrow head), proper hepatic artery (white arrow head)].
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Figure 3: Three-dimensional volume rendered image of hepatic vascular system (A) and magnified image of the area demarcated by the white dotted rectangle (B). [Celiac axis (black arrow), splenic artery (white arrow), gastroduodenal artery (small white arrow), left gastric artery (small black arrow), common hepatic artery (black arrow head), proper hepatic artery (white arrow head)].

Mentions: The mean total and right lobe volume of the liver was 698.57 ± 47.81 ml and 420.14 ± 26.70 ml, which were 51.74% and 49.35% of the human total and right lobe liver volume, respectively. For the micropigs, the percentage of liver volume to body weight was approximately 2.05% and there was a significant relationship between body weight and liver volume (p < 0.05). The axial CT images of the common hepatic artery, proper hepatic artery and portal vein are shown in Fig. 2. The virtual three-dimensional liver image of the hepatic vascular system reconstructed with serial CT images is shown in Fig. 3, and the diameter of common hepatic artery, proper hepatic artery, and portal vein were estimated (Table 1).


Imaging evaluation of the liver using multi-detector row computed tomography in micropigs as potential living liver donors.

Ryu JM, Kim DH, Lee MY, Lee SH, Park JH, Yun SP, Jang MW, Kim SH, Rho GJ, Han HJ - J. Vet. Sci. (2009)

Three-dimensional volume rendered image of hepatic vascular system (A) and magnified image of the area demarcated by the white dotted rectangle (B). [Celiac axis (black arrow), splenic artery (white arrow), gastroduodenal artery (small white arrow), left gastric artery (small black arrow), common hepatic artery (black arrow head), proper hepatic artery (white arrow head)].
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC2801117&req=5

Figure 3: Three-dimensional volume rendered image of hepatic vascular system (A) and magnified image of the area demarcated by the white dotted rectangle (B). [Celiac axis (black arrow), splenic artery (white arrow), gastroduodenal artery (small white arrow), left gastric artery (small black arrow), common hepatic artery (black arrow head), proper hepatic artery (white arrow head)].
Mentions: The mean total and right lobe volume of the liver was 698.57 ± 47.81 ml and 420.14 ± 26.70 ml, which were 51.74% and 49.35% of the human total and right lobe liver volume, respectively. For the micropigs, the percentage of liver volume to body weight was approximately 2.05% and there was a significant relationship between body weight and liver volume (p < 0.05). The axial CT images of the common hepatic artery, proper hepatic artery and portal vein are shown in Fig. 2. The virtual three-dimensional liver image of the hepatic vascular system reconstructed with serial CT images is shown in Fig. 3, and the diameter of common hepatic artery, proper hepatic artery, and portal vein were estimated (Table 1).

Bottom Line: The diameters of the common hepatic artery and proper hepatic artery were 6.24 +/- 0.20 mm and 4.68 +/- 0.13 mm, respectively.The hepatic vascular system of the micropigs was similar to that of humans, except for the variation in the length of the proper hepatic artery.In addition, the diameter of the portal vein was 11.27 +/- 0.38 mm.

View Article: PubMed Central - PubMed

Affiliation: Department of Veterinary Physiology, College of Veterinary Medicine, Biotherapy Human Resources Center (BK21), Chonnam National University, Gwangju, Korea.

ABSTRACT
The shortage of organ donors has stimulated interest in the possibility of using animal organs for transplantation into humans. In addition, pigs are now considered to be the most likely source animals for human xenotransplantation because of their advantages over non-human primates. However, the appropriate standard values for estimations of the liver of micropigs have not been established. The determination of standard values for the micropig liver using multi-detector row computed tomography (MDCT) would help to select a suitable donor for an individual patient, determine the condition of the liver of the micropigs and help predict patient prognosis. Therefore, we determined the standard values for the livers of micropigs using MDCT. The liver parenchyma showed homogenous enhancement and had no space-occupying lesions. The total and right lobe volumes of the liver were 698.57 +/- 47.81 ml and 420.14 +/- 26.70 ml, which are 51.74% and 49.35% of the human liver volume, respectively. In micropigs, the percentage of liver volume to body weight was approximately 2.05%. The diameters of the common hepatic artery and proper hepatic artery were 6.24 +/- 0.20 mm and 4.68 +/- 0.13 mm, respectively. The hepatic vascular system of the micropigs was similar to that of humans, except for the variation in the length of the proper hepatic artery. In addition, the diameter of the portal vein was 11.27 +/- 0.38 mm. In conclusion, imaging evaluation using the MDCT was a reliable method for liver evaluation and its vascular anatomy for xenotransplantation using micropigs.

Show MeSH
Related in: MedlinePlus