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Effects of mosapride on motility of the small intestine and caecum in normal horses after jejunocaecostomy.

Okamura K, Sasaki N, Kikuchi T, Murata A, Lee I, Yamada H, Inokuma H - J. Vet. Sci. (2009)

Bottom Line: The electrointestinography (EIG) maximum amplitude was used to measure intestinal motility.Motility significantly decreased following surgery.In the treated group, the EIG maximum amplitude of the small intestine was significantly higher than in the controls from day 6 approximately 31 after treatment.

View Article: PubMed Central - PubMed

Affiliation: The United Graduate School of Veterinary Sciences, Gifu University, Gifu-shi, Japan.

ABSTRACT
The purpose of the present study was to evaluate the prokinetic effects of mosapride with non-invasive assessment of myoelectrical activity in the small intestine and caecum of healthy horses after jejunocaecostomy. Six horses underwent celiotomy and jejunocaecostomy, and were treated with mosapride (treated group) at 1.5 mg/kg per osos once daily for 5 days after surgery. The other six horses did not receive treatment and were used as controls (non-treated group). The electrointestinography (EIG) maximum amplitude was used to measure intestinal motility. Motility significantly decreased following surgery. In the treated group, the EIG maximum amplitude of the small intestine was significantly higher than in the controls from day 6 approximately 31 after treatment. These findings clearly indicate that mosapride could overcome the decline of intestinal motility after jejunocaecostomy in normal horses.

Show MeSH
Electrointestinography (EIG) electrode position. A: Small intestine, B: Ceacum, ●: EIG mini-amplifier, ○: EIG in different electrodes.
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Figure 1: Electrointestinography (EIG) electrode position. A: Small intestine, B: Ceacum, ●: EIG mini-amplifier, ○: EIG in different electrodes.

Mentions: EIGs of the small intestine and caecum were performed on conscious horses at rest in a stall. After clipping the hair over the paralumbar fossa on the left and right sides of the abdomen, the skin was washed and EIG electrodes were installed via surface electrodes (Vitrode M-150 Disposable Electrodes; Nihon Kohden, Japan) at three sites: the front edge of the tuber coxae (EIG mini-amplifier), the intersection of the horizontal line extending from the tuber coxae and the rear edge of the last rib (noninductive electrodes), and the apex of an inverted regular triangle formed by placing the other two electrodes on the other apexes (EIG mini-amplifier; Fig. 1). At a sampling rate of 1 Hz, the frequency was measured within the range of 1.6~12 cycles per min. An electrogastrographic (EGG) recorder (Nipro EG; A&D, Japan) and a digitrapper EGG system were used to measure the percutaneous potential of the small intestine and caecum [10]. The system was attached to the trunk by means of a saddle, a girth, and a saddlecloth.


Effects of mosapride on motility of the small intestine and caecum in normal horses after jejunocaecostomy.

Okamura K, Sasaki N, Kikuchi T, Murata A, Lee I, Yamada H, Inokuma H - J. Vet. Sci. (2009)

Electrointestinography (EIG) electrode position. A: Small intestine, B: Ceacum, ●: EIG mini-amplifier, ○: EIG in different electrodes.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC2801111&req=5

Figure 1: Electrointestinography (EIG) electrode position. A: Small intestine, B: Ceacum, ●: EIG mini-amplifier, ○: EIG in different electrodes.
Mentions: EIGs of the small intestine and caecum were performed on conscious horses at rest in a stall. After clipping the hair over the paralumbar fossa on the left and right sides of the abdomen, the skin was washed and EIG electrodes were installed via surface electrodes (Vitrode M-150 Disposable Electrodes; Nihon Kohden, Japan) at three sites: the front edge of the tuber coxae (EIG mini-amplifier), the intersection of the horizontal line extending from the tuber coxae and the rear edge of the last rib (noninductive electrodes), and the apex of an inverted regular triangle formed by placing the other two electrodes on the other apexes (EIG mini-amplifier; Fig. 1). At a sampling rate of 1 Hz, the frequency was measured within the range of 1.6~12 cycles per min. An electrogastrographic (EGG) recorder (Nipro EG; A&D, Japan) and a digitrapper EGG system were used to measure the percutaneous potential of the small intestine and caecum [10]. The system was attached to the trunk by means of a saddle, a girth, and a saddlecloth.

Bottom Line: The electrointestinography (EIG) maximum amplitude was used to measure intestinal motility.Motility significantly decreased following surgery.In the treated group, the EIG maximum amplitude of the small intestine was significantly higher than in the controls from day 6 approximately 31 after treatment.

View Article: PubMed Central - PubMed

Affiliation: The United Graduate School of Veterinary Sciences, Gifu University, Gifu-shi, Japan.

ABSTRACT
The purpose of the present study was to evaluate the prokinetic effects of mosapride with non-invasive assessment of myoelectrical activity in the small intestine and caecum of healthy horses after jejunocaecostomy. Six horses underwent celiotomy and jejunocaecostomy, and were treated with mosapride (treated group) at 1.5 mg/kg per osos once daily for 5 days after surgery. The other six horses did not receive treatment and were used as controls (non-treated group). The electrointestinography (EIG) maximum amplitude was used to measure intestinal motility. Motility significantly decreased following surgery. In the treated group, the EIG maximum amplitude of the small intestine was significantly higher than in the controls from day 6 approximately 31 after treatment. These findings clearly indicate that mosapride could overcome the decline of intestinal motility after jejunocaecostomy in normal horses.

Show MeSH