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NaCl plus chitosan as a dietary salt to prevent the development of hypertension in spontaneously hypertensive rats.

Park SH, Dutta NK, Baek MW, Kim DJ, Na YR, Seok SH, Lee BH, Cho JE, Cho GS, Park JH - J. Vet. Sci. (2009)

Bottom Line: NaCl plus chitosan resulted, though not statistically significant, in decreased urinary Na(+) excretion and decreased blood urea nitrogen levels.Urinary creatinine of NaCl plus chitosan was slightly decreased compared to 3 treated groups.Even though these supplementary diets have demonstrated potential anti-hypertensive effects in the experimental animal model, further research is needed before any recommendations can be made.

View Article: PubMed Central - PubMed

Affiliation: Laboratory Animal Medicine, and KRF Priority Zoonotic Disease Research Institute, College of Veterinary Medicine, Seoul National University, Seoul, Korea.

ABSTRACT
The effect of NaCl plus 3% chitosan on the systolic blood pressure of spontaneously hypertensive rats (SHR) were evaluated and compared with NaCl plus KCl (NaCl, 49.36% + KCl 49.36%) and chitosan or NaCl treatment alone. In SHR, administration of NaCl plus chitosan (44 mM Na/day) for two months significantly decreased the systolic blood pressure greater than of NaCl plus KCl and NaCl alone. NaCl plus chitosan resulted, though not statistically significant, in decreased urinary Na(+) excretion and decreased blood urea nitrogen levels. Urinary creatinine of NaCl plus chitosan was slightly decreased compared to 3 treated groups. Serum electrolytes levels, however, remained unchanged. The combination of NaCl and chitosan may be superior to the conventional use of NaCl plus KCl or NaCl alone in the prevention of hypertension. Even though these supplementary diets have demonstrated potential anti-hypertensive effects in the experimental animal model, further research is needed before any recommendations can be made.

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Related in: MedlinePlus

Effect of dietary salts on urine electrolytes (Na+, K+ and Cl-). Vertical bars represent the mean ± SD (n = 5).
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Figure 5: Effect of dietary salts on urine electrolytes (Na+, K+ and Cl-). Vertical bars represent the mean ± SD (n = 5).

Mentions: In this study, serum electrolytes were similar and unchanged in all groups (Fig. 4). In general, sodium levels were the highest followed by chlorine and potassium. Na+, K+ and Cl- levels in the urine did not differ significantly between the control and the test groups regardless of treatments, but there was a tendency toward an decrease in urinary Na+ excretion when treated with NaCl plus chitosan compared to NaCl + KCl or NaCl alone group (Fig. 5).


NaCl plus chitosan as a dietary salt to prevent the development of hypertension in spontaneously hypertensive rats.

Park SH, Dutta NK, Baek MW, Kim DJ, Na YR, Seok SH, Lee BH, Cho JE, Cho GS, Park JH - J. Vet. Sci. (2009)

Effect of dietary salts on urine electrolytes (Na+, K+ and Cl-). Vertical bars represent the mean ± SD (n = 5).
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC2801110&req=5

Figure 5: Effect of dietary salts on urine electrolytes (Na+, K+ and Cl-). Vertical bars represent the mean ± SD (n = 5).
Mentions: In this study, serum electrolytes were similar and unchanged in all groups (Fig. 4). In general, sodium levels were the highest followed by chlorine and potassium. Na+, K+ and Cl- levels in the urine did not differ significantly between the control and the test groups regardless of treatments, but there was a tendency toward an decrease in urinary Na+ excretion when treated with NaCl plus chitosan compared to NaCl + KCl or NaCl alone group (Fig. 5).

Bottom Line: NaCl plus chitosan resulted, though not statistically significant, in decreased urinary Na(+) excretion and decreased blood urea nitrogen levels.Urinary creatinine of NaCl plus chitosan was slightly decreased compared to 3 treated groups.Even though these supplementary diets have demonstrated potential anti-hypertensive effects in the experimental animal model, further research is needed before any recommendations can be made.

View Article: PubMed Central - PubMed

Affiliation: Laboratory Animal Medicine, and KRF Priority Zoonotic Disease Research Institute, College of Veterinary Medicine, Seoul National University, Seoul, Korea.

ABSTRACT
The effect of NaCl plus 3% chitosan on the systolic blood pressure of spontaneously hypertensive rats (SHR) were evaluated and compared with NaCl plus KCl (NaCl, 49.36% + KCl 49.36%) and chitosan or NaCl treatment alone. In SHR, administration of NaCl plus chitosan (44 mM Na/day) for two months significantly decreased the systolic blood pressure greater than of NaCl plus KCl and NaCl alone. NaCl plus chitosan resulted, though not statistically significant, in decreased urinary Na(+) excretion and decreased blood urea nitrogen levels. Urinary creatinine of NaCl plus chitosan was slightly decreased compared to 3 treated groups. Serum electrolytes levels, however, remained unchanged. The combination of NaCl and chitosan may be superior to the conventional use of NaCl plus KCl or NaCl alone in the prevention of hypertension. Even though these supplementary diets have demonstrated potential anti-hypertensive effects in the experimental animal model, further research is needed before any recommendations can be made.

Show MeSH
Related in: MedlinePlus