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NaCl plus chitosan as a dietary salt to prevent the development of hypertension in spontaneously hypertensive rats.

Park SH, Dutta NK, Baek MW, Kim DJ, Na YR, Seok SH, Lee BH, Cho JE, Cho GS, Park JH - J. Vet. Sci. (2009)

Bottom Line: NaCl plus chitosan resulted, though not statistically significant, in decreased urinary Na(+) excretion and decreased blood urea nitrogen levels.Urinary creatinine of NaCl plus chitosan was slightly decreased compared to 3 treated groups.Even though these supplementary diets have demonstrated potential anti-hypertensive effects in the experimental animal model, further research is needed before any recommendations can be made.

View Article: PubMed Central - PubMed

Affiliation: Laboratory Animal Medicine, and KRF Priority Zoonotic Disease Research Institute, College of Veterinary Medicine, Seoul National University, Seoul, Korea.

ABSTRACT
The effect of NaCl plus 3% chitosan on the systolic blood pressure of spontaneously hypertensive rats (SHR) were evaluated and compared with NaCl plus KCl (NaCl, 49.36% + KCl 49.36%) and chitosan or NaCl treatment alone. In SHR, administration of NaCl plus chitosan (44 mM Na/day) for two months significantly decreased the systolic blood pressure greater than of NaCl plus KCl and NaCl alone. NaCl plus chitosan resulted, though not statistically significant, in decreased urinary Na(+) excretion and decreased blood urea nitrogen levels. Urinary creatinine of NaCl plus chitosan was slightly decreased compared to 3 treated groups. Serum electrolytes levels, however, remained unchanged. The combination of NaCl and chitosan may be superior to the conventional use of NaCl plus KCl or NaCl alone in the prevention of hypertension. Even though these supplementary diets have demonstrated potential anti-hypertensive effects in the experimental animal model, further research is needed before any recommendations can be made.

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Related in: MedlinePlus

Changes in systolic blood pressure of spontaneously hypertensive rats administered various combinations of dietary salts. Means with the same alphabetical letter are not significantly different (p < 0.05). Vertical bars represent the mean ± SD (n = 5).
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Figure 2: Changes in systolic blood pressure of spontaneously hypertensive rats administered various combinations of dietary salts. Means with the same alphabetical letter are not significantly different (p < 0.05). Vertical bars represent the mean ± SD (n = 5).

Mentions: A continuous increase (control: 195.60 ± 7.90 to 215.50 ± 5.20 mmHg) in the systolic blood pressure (SBP) was seen in all the groups during the experimental period. In general, SBP of the NaCl plus chitosan-treated group was lower than that of the KCl plus NaCl-treated group (232.50 ± 7.60 mmHg) and the NaCl-treated group and higher than that of the chitosan-treated group (212.40 ± 5.70 mmHg) and control group. There was a significant decrease (p < 0.05) in SBP in the pure NaCl plus chitosan group at 2 week only when compared to the KCl plus NaCl treated group, but not at 8th week (Fig. 2).


NaCl plus chitosan as a dietary salt to prevent the development of hypertension in spontaneously hypertensive rats.

Park SH, Dutta NK, Baek MW, Kim DJ, Na YR, Seok SH, Lee BH, Cho JE, Cho GS, Park JH - J. Vet. Sci. (2009)

Changes in systolic blood pressure of spontaneously hypertensive rats administered various combinations of dietary salts. Means with the same alphabetical letter are not significantly different (p < 0.05). Vertical bars represent the mean ± SD (n = 5).
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC2801110&req=5

Figure 2: Changes in systolic blood pressure of spontaneously hypertensive rats administered various combinations of dietary salts. Means with the same alphabetical letter are not significantly different (p < 0.05). Vertical bars represent the mean ± SD (n = 5).
Mentions: A continuous increase (control: 195.60 ± 7.90 to 215.50 ± 5.20 mmHg) in the systolic blood pressure (SBP) was seen in all the groups during the experimental period. In general, SBP of the NaCl plus chitosan-treated group was lower than that of the KCl plus NaCl-treated group (232.50 ± 7.60 mmHg) and the NaCl-treated group and higher than that of the chitosan-treated group (212.40 ± 5.70 mmHg) and control group. There was a significant decrease (p < 0.05) in SBP in the pure NaCl plus chitosan group at 2 week only when compared to the KCl plus NaCl treated group, but not at 8th week (Fig. 2).

Bottom Line: NaCl plus chitosan resulted, though not statistically significant, in decreased urinary Na(+) excretion and decreased blood urea nitrogen levels.Urinary creatinine of NaCl plus chitosan was slightly decreased compared to 3 treated groups.Even though these supplementary diets have demonstrated potential anti-hypertensive effects in the experimental animal model, further research is needed before any recommendations can be made.

View Article: PubMed Central - PubMed

Affiliation: Laboratory Animal Medicine, and KRF Priority Zoonotic Disease Research Institute, College of Veterinary Medicine, Seoul National University, Seoul, Korea.

ABSTRACT
The effect of NaCl plus 3% chitosan on the systolic blood pressure of spontaneously hypertensive rats (SHR) were evaluated and compared with NaCl plus KCl (NaCl, 49.36% + KCl 49.36%) and chitosan or NaCl treatment alone. In SHR, administration of NaCl plus chitosan (44 mM Na/day) for two months significantly decreased the systolic blood pressure greater than of NaCl plus KCl and NaCl alone. NaCl plus chitosan resulted, though not statistically significant, in decreased urinary Na(+) excretion and decreased blood urea nitrogen levels. Urinary creatinine of NaCl plus chitosan was slightly decreased compared to 3 treated groups. Serum electrolytes levels, however, remained unchanged. The combination of NaCl and chitosan may be superior to the conventional use of NaCl plus KCl or NaCl alone in the prevention of hypertension. Even though these supplementary diets have demonstrated potential anti-hypertensive effects in the experimental animal model, further research is needed before any recommendations can be made.

Show MeSH
Related in: MedlinePlus