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HPV prevalence in Colombian women with cervical cancer: implications for vaccination in a developing country.

Murillo R, Molano M, Martínez G, Mejía JC, Gamboa O - Infect Dis Obstet Gynecol (2009)

Bottom Line: HPV-16/18 prevalence was 63.1%; HPV-18 had lower occurrence in the high-risk population (13.8% versus 9.6%) allowing for the participation of less common HPV types; HPV-45 was present mainly in women under 50 and age-specific HPV type prevalence revealed significant differences.Multiple high-risk infections appeared in 16.6% of cases and represent a chance of replacement.Both factors highlight the role of HPVs other than 16/18, which should be considered in cost-effectiveness analyses for potential vaccine impact.

View Article: PubMed Central - PubMed

Affiliation: Subdirección Investigaciones, Instituto Nacional de Cancerología de Colombia, Bogota, Colombia. raulhmurillo@yahoo.com

ABSTRACT
Human Papillomavirus (HPV) vaccines have been considered potentially cost-effective for the reduction of cervical cancer burden in developing countries; their effectiveness in a public health setting continues to be researched. We conducted an HPV prevalence survey among Colombian women with invasive cancer. Paraffin-embedded biopsies were obtained from one high-risk and one low-middle-risk regions. GP5+/GP6+ L1 primers, RLB assays, and E7 type specific PCR were used for HPV-DNA detection. 217 cases were analyzed with 97.7% HPV detection rate. HPV-16/18 prevalence was 63.1%; HPV-18 had lower occurrence in the high-risk population (13.8% versus 9.6%) allowing for the participation of less common HPV types; HPV-45 was present mainly in women under 50 and age-specific HPV type prevalence revealed significant differences. Multiple high-risk infections appeared in 16.6% of cases and represent a chance of replacement. Age-specific HPV prevalence and multiple high-risk infections might influence vaccine impact. Both factors highlight the role of HPVs other than 16/18, which should be considered in cost-effectiveness analyses for potential vaccine impact.

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Related in: MedlinePlus

Distribution of HPV types over and under age 50. Each bar represents 100% of cases for each HPV type. HR-HPV types counted in less than 10 cases were grouped as other HR-HPV. Single infections assumed after distribution of multiple infections.
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fig2: Distribution of HPV types over and under age 50. Each bar represents 100% of cases for each HPV type. HR-HPV types counted in less than 10 cases were grouped as other HR-HPV. Single infections assumed after distribution of multiple infections.

Mentions: HPV types varied among women depending upon age at diagnosis of cervical cancer. For women under 50 the most common types were HPV-16 (55.4%), HPV-45 (14.3%), HPV-18 (10.1%), and HPV-31 (5.4%); for women 50-59, the most common types were HPV-16 (55.3%), HPV-18 (21.8%), HPV-58 (8%), and HPV-56 (3.4%); for women over 60, the most common types were HPV-16 (37.9%), HPV-58 (11.9%), HPV-33 (10.7%), and HPV-31 (9.8%). When considering age distribution for a given HPV type, HPVs 16 and 18 distributed evenly across age groups; most HPV-45 infections occurred before age 50 (82%, P = .02), and less common types (HPV 58 and 33) occurred mostly after age 50 and even over 60 (P > .05) (Figure 2).


HPV prevalence in Colombian women with cervical cancer: implications for vaccination in a developing country.

Murillo R, Molano M, Martínez G, Mejía JC, Gamboa O - Infect Dis Obstet Gynecol (2009)

Distribution of HPV types over and under age 50. Each bar represents 100% of cases for each HPV type. HR-HPV types counted in less than 10 cases were grouped as other HR-HPV. Single infections assumed after distribution of multiple infections.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC2801009&req=5

fig2: Distribution of HPV types over and under age 50. Each bar represents 100% of cases for each HPV type. HR-HPV types counted in less than 10 cases were grouped as other HR-HPV. Single infections assumed after distribution of multiple infections.
Mentions: HPV types varied among women depending upon age at diagnosis of cervical cancer. For women under 50 the most common types were HPV-16 (55.4%), HPV-45 (14.3%), HPV-18 (10.1%), and HPV-31 (5.4%); for women 50-59, the most common types were HPV-16 (55.3%), HPV-18 (21.8%), HPV-58 (8%), and HPV-56 (3.4%); for women over 60, the most common types were HPV-16 (37.9%), HPV-58 (11.9%), HPV-33 (10.7%), and HPV-31 (9.8%). When considering age distribution for a given HPV type, HPVs 16 and 18 distributed evenly across age groups; most HPV-45 infections occurred before age 50 (82%, P = .02), and less common types (HPV 58 and 33) occurred mostly after age 50 and even over 60 (P > .05) (Figure 2).

Bottom Line: HPV-16/18 prevalence was 63.1%; HPV-18 had lower occurrence in the high-risk population (13.8% versus 9.6%) allowing for the participation of less common HPV types; HPV-45 was present mainly in women under 50 and age-specific HPV type prevalence revealed significant differences.Multiple high-risk infections appeared in 16.6% of cases and represent a chance of replacement.Both factors highlight the role of HPVs other than 16/18, which should be considered in cost-effectiveness analyses for potential vaccine impact.

View Article: PubMed Central - PubMed

Affiliation: Subdirección Investigaciones, Instituto Nacional de Cancerología de Colombia, Bogota, Colombia. raulhmurillo@yahoo.com

ABSTRACT
Human Papillomavirus (HPV) vaccines have been considered potentially cost-effective for the reduction of cervical cancer burden in developing countries; their effectiveness in a public health setting continues to be researched. We conducted an HPV prevalence survey among Colombian women with invasive cancer. Paraffin-embedded biopsies were obtained from one high-risk and one low-middle-risk regions. GP5+/GP6+ L1 primers, RLB assays, and E7 type specific PCR were used for HPV-DNA detection. 217 cases were analyzed with 97.7% HPV detection rate. HPV-16/18 prevalence was 63.1%; HPV-18 had lower occurrence in the high-risk population (13.8% versus 9.6%) allowing for the participation of less common HPV types; HPV-45 was present mainly in women under 50 and age-specific HPV type prevalence revealed significant differences. Multiple high-risk infections appeared in 16.6% of cases and represent a chance of replacement. Age-specific HPV prevalence and multiple high-risk infections might influence vaccine impact. Both factors highlight the role of HPVs other than 16/18, which should be considered in cost-effectiveness analyses for potential vaccine impact.

Show MeSH
Related in: MedlinePlus