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A study comparing chemical peeling using modified Jessner's solution and 15% trichloroacetic Acid versus 15% trichloroacetic acid in the treatment of melasma.

Safoury OS, Zaki NM, El Nabarawy EA, Farag EA - Indian J Dermatol (2009)

Bottom Line: Fifteen percent TCA was applied to the whole face, with the exception of the left malar area to which combined TCA 15% and modified Jessner's solution was applied.Our results revealed statistically highly significant difference between MASI Score (Melasma Area and Severity Index) between the right malar area and the left malar area.Modified Jessner's solution proved to be useful as an adjuvant treatment with TCA in the treatment of melasma, improving the results and minimizing postinflammatory hyperpigmentation.

View Article: PubMed Central - PubMed

Affiliation: Department of Dermatology, Cairo University, Cairo, Egypt. omar_safoury@hotmail.com

ABSTRACT

Background: Melasma is a symmetric progressive hyperpigmentation of the facial skin that occurs in all races but has a predilection for darker skin phenotypes. Depigmenting agents, laser and chemical peeling as classic Jessner's solution, modified Jessner's solution and trichloroacetic acid have been used alone and in combination in the treatment of melasma.

Objectives: The aim of the study was to compare the therapeutic effect of combined 15% Trichloroacetic acid (TCA) and modified Jessner's solution with 15% TCA on melasma.

Materials and methods: Twenty married females with melasma (epidermal type), with a mean age of 38.25 years, were included in this study. All were of skin type III or IV. Fifteen percent TCA was applied to the whole face, with the exception of the left malar area to which combined TCA 15% and modified Jessner's solution was applied.

Results: Our results revealed statistically highly significant difference between MASI Score (Melasma Area and Severity Index) between the right malar area and the left malar area.

Conclusion: Modified Jessner's solution proved to be useful as an adjuvant treatment with TCA in the treatment of melasma, improving the results and minimizing postinflammatory hyperpigmentation.

No MeSH data available.


Related in: MedlinePlus

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Figure 0004: Left side after

Mentions: The average (mean) MASI score in the left malar area before treatment was 4.350 ± 1.468, whereas after treatment (at the end of eight peeling sessions), the average MASI score changed to 1.230 ± 0.808 [Figure 3, Figure 4]. So, the average decrease in MASI score was 3.120. This represents a 71.72% decrease and was statistically highly significant. (P = 0.000) (P value is highly significant if ≤0.01).


A study comparing chemical peeling using modified Jessner's solution and 15% trichloroacetic Acid versus 15% trichloroacetic acid in the treatment of melasma.

Safoury OS, Zaki NM, El Nabarawy EA, Farag EA - Indian J Dermatol (2009)

Left side after
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC2800869&req=5

Figure 0004: Left side after
Mentions: The average (mean) MASI score in the left malar area before treatment was 4.350 ± 1.468, whereas after treatment (at the end of eight peeling sessions), the average MASI score changed to 1.230 ± 0.808 [Figure 3, Figure 4]. So, the average decrease in MASI score was 3.120. This represents a 71.72% decrease and was statistically highly significant. (P = 0.000) (P value is highly significant if ≤0.01).

Bottom Line: Fifteen percent TCA was applied to the whole face, with the exception of the left malar area to which combined TCA 15% and modified Jessner's solution was applied.Our results revealed statistically highly significant difference between MASI Score (Melasma Area and Severity Index) between the right malar area and the left malar area.Modified Jessner's solution proved to be useful as an adjuvant treatment with TCA in the treatment of melasma, improving the results and minimizing postinflammatory hyperpigmentation.

View Article: PubMed Central - PubMed

Affiliation: Department of Dermatology, Cairo University, Cairo, Egypt. omar_safoury@hotmail.com

ABSTRACT

Background: Melasma is a symmetric progressive hyperpigmentation of the facial skin that occurs in all races but has a predilection for darker skin phenotypes. Depigmenting agents, laser and chemical peeling as classic Jessner's solution, modified Jessner's solution and trichloroacetic acid have been used alone and in combination in the treatment of melasma.

Objectives: The aim of the study was to compare the therapeutic effect of combined 15% Trichloroacetic acid (TCA) and modified Jessner's solution with 15% TCA on melasma.

Materials and methods: Twenty married females with melasma (epidermal type), with a mean age of 38.25 years, were included in this study. All were of skin type III or IV. Fifteen percent TCA was applied to the whole face, with the exception of the left malar area to which combined TCA 15% and modified Jessner's solution was applied.

Results: Our results revealed statistically highly significant difference between MASI Score (Melasma Area and Severity Index) between the right malar area and the left malar area.

Conclusion: Modified Jessner's solution proved to be useful as an adjuvant treatment with TCA in the treatment of melasma, improving the results and minimizing postinflammatory hyperpigmentation.

No MeSH data available.


Related in: MedlinePlus