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Alopecia areata is not associated with Helicobacter pylori.

Abdel Hafez HZ, Mahran AM, Hofny EM, Attallah DA, Sayed DS, Rashed H - Indian J Dermatol (2009)

Bottom Line: Helicobacter pylori has been associated with many extra-digestive dermatological conditions.Optical density values for H. pylori infection was positive in 18 of the 31 patients evaluated (58.1%), while in 13 patients, the values did not support H. pylori infection (41.9%).In the control group, 10 of the 24 (41.7%) had positive results.

View Article: PubMed Central - PubMed

Affiliation: Department of Dermatology, Assiut University Hospital, Egypt. hishamzayan@yahoo.com

ABSTRACT

Background: Alopecia areata (AA) is an immune-mediated form of hair loss that occurs in all ethnic groups, ages, and both sexes. Helicobacter pylori has been associated with many extra-digestive dermatological conditions. The causal relation between alopecia areata and Helicobacter pylori is discussed in this study.

Materials and methods: We have screened for the presence of H. pylori in patients with AA, in order to determine any potential role in its patho-physiology. We have prospectively studied 31 patients with alopecia areata and 24 healthy volunteers of similar gender, for the presence of H. pylori stool antigen (HpSAg).

Results: Optical density values for H. pylori infection was positive in 18 of the 31 patients evaluated (58.1%), while in 13 patients, the values did not support H. pylori infection (41.9%). In the control group, 10 of the 24 (41.7%) had positive results. Within the group of alopecia areata, there was no significant difference between HpSAg positive and negative patients.

Conclusions: The results have shown that a relation between Helicobacter pylori and alopecia areata is not supported. We advise that H. pylori detection need not to be included in the laboratory work up of alopecia areata.

No MeSH data available.


Related in: MedlinePlus

Scaterrogram for HpSA among both groups of the study
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Figure 0001: Scaterrogram for HpSA among both groups of the study

Mentions: Both the groups were comparable in terms of age (mean 24.48 vs 27.50 years) and sex (67.7% vs 58.3% males in both). Optical density values for H. pylori infection was positive in 18 of all the 31 patients evaluated (58.1%), while in 13 patients optical density values did not support H. pylori infection (41.9%). In the control group, 10 of 24 (41.7%) had positive results [Figure 1]. Although the mean of H. pylori stool antigen (HpSAg) was higher in the AA group, it did not reach statistical significance between the two groups.


Alopecia areata is not associated with Helicobacter pylori.

Abdel Hafez HZ, Mahran AM, Hofny EM, Attallah DA, Sayed DS, Rashed H - Indian J Dermatol (2009)

Scaterrogram for HpSA among both groups of the study
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC2800863&req=5

Figure 0001: Scaterrogram for HpSA among both groups of the study
Mentions: Both the groups were comparable in terms of age (mean 24.48 vs 27.50 years) and sex (67.7% vs 58.3% males in both). Optical density values for H. pylori infection was positive in 18 of all the 31 patients evaluated (58.1%), while in 13 patients optical density values did not support H. pylori infection (41.9%). In the control group, 10 of 24 (41.7%) had positive results [Figure 1]. Although the mean of H. pylori stool antigen (HpSAg) was higher in the AA group, it did not reach statistical significance between the two groups.

Bottom Line: Helicobacter pylori has been associated with many extra-digestive dermatological conditions.Optical density values for H. pylori infection was positive in 18 of the 31 patients evaluated (58.1%), while in 13 patients, the values did not support H. pylori infection (41.9%).In the control group, 10 of the 24 (41.7%) had positive results.

View Article: PubMed Central - PubMed

Affiliation: Department of Dermatology, Assiut University Hospital, Egypt. hishamzayan@yahoo.com

ABSTRACT

Background: Alopecia areata (AA) is an immune-mediated form of hair loss that occurs in all ethnic groups, ages, and both sexes. Helicobacter pylori has been associated with many extra-digestive dermatological conditions. The causal relation between alopecia areata and Helicobacter pylori is discussed in this study.

Materials and methods: We have screened for the presence of H. pylori in patients with AA, in order to determine any potential role in its patho-physiology. We have prospectively studied 31 patients with alopecia areata and 24 healthy volunteers of similar gender, for the presence of H. pylori stool antigen (HpSAg).

Results: Optical density values for H. pylori infection was positive in 18 of the 31 patients evaluated (58.1%), while in 13 patients, the values did not support H. pylori infection (41.9%). In the control group, 10 of the 24 (41.7%) had positive results. Within the group of alopecia areata, there was no significant difference between HpSAg positive and negative patients.

Conclusions: The results have shown that a relation between Helicobacter pylori and alopecia areata is not supported. We advise that H. pylori detection need not to be included in the laboratory work up of alopecia areata.

No MeSH data available.


Related in: MedlinePlus