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Salicylic acid sans aspirin in animals and man: persistence in fasting and biosynthesis from benzoic acid.

Paterson JR, Baxter G, Dreyer JS, Halket JM, Flynn R, Lawrence JR - J. Agric. Food Chem. (2008)

Bottom Line: Fasting for major colorectal surgery did not cause disappearance of SA from plasma, even in patients following total proctocolectomy.A (13)C(6) benzoic acid load ingested by six volunteers led, between 8 and 16 h, to a median 33.9% labeling of urinary salicyluric acid.The overall contribution of benzoic acid (and its salts) to the turnover of circulating SA thus requires further assessment.

View Article: PubMed Central - PubMed

Affiliation: Dumfries and Galloway Royal Infirmary, Bankend Road, Dumfries DG1 4AP, United Kingdom.

ABSTRACT
Salicylic acid (SA), which is central to defense mechanisms in plants and the principal metabolite of aspirin, occurs naturally in man with higher levels of SA and its urinary metabolite salicyluric acid (SU) in vegetarians overlapping with levels in patients on low-dose aspirin regimens. SA is widely distributed in animal blood. Fasting for major colorectal surgery did not cause disappearance of SA from plasma, even in patients following total proctocolectomy. A (13)C(6) benzoic acid load ingested by six volunteers led, between 8 and 16 h, to a median 33.9% labeling of urinary salicyluric acid. The overall contribution of benzoic acid (and its salts) to the turnover of circulating SA thus requires further assessment. However, that SA appears to be, at least partially, an endogenous compound should lead to reassessment of its role in human (and animal) pathophysiology.

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Related in: MedlinePlus

Urinary SA + SU excreted throughout time course of 13C experiment: total SA + SU excreted during the 8 h urine collection periods. The columns represent the median value and the error bars the maximum and minimum values. The dotted line at 24 h shows the point at which the first dose of benzoic acid was introduced. One subject was omitted because of incomplete data.
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fig2: Urinary SA + SU excreted throughout time course of 13C experiment: total SA + SU excreted during the 8 h urine collection periods. The columns represent the median value and the error bars the maximum and minimum values. The dotted line at 24 h shows the point at which the first dose of benzoic acid was introduced. One subject was omitted because of incomplete data.

Mentions: Further examination of the possible biosynthesis of SA in man required a labeled precursor study. That showed variability in total serum SA during the study, but in every individual the highest serum SA measured during the 3 days occurred during day 2—at a median time of 4 h (range = 2−8 h) after the first dose of benzoic acid. The areas under the SA level time curves confirmed the highest serum levels were reached on day 2, but that was not significant. The highest level (Figure 2, p = 0.052) of combined SA + SU urinary excretion was observed in the 8−16 h sample after the initial dose of benzoic acid.


Salicylic acid sans aspirin in animals and man: persistence in fasting and biosynthesis from benzoic acid.

Paterson JR, Baxter G, Dreyer JS, Halket JM, Flynn R, Lawrence JR - J. Agric. Food Chem. (2008)

Urinary SA + SU excreted throughout time course of 13C experiment: total SA + SU excreted during the 8 h urine collection periods. The columns represent the median value and the error bars the maximum and minimum values. The dotted line at 24 h shows the point at which the first dose of benzoic acid was introduced. One subject was omitted because of incomplete data.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC2800778&req=5

fig2: Urinary SA + SU excreted throughout time course of 13C experiment: total SA + SU excreted during the 8 h urine collection periods. The columns represent the median value and the error bars the maximum and minimum values. The dotted line at 24 h shows the point at which the first dose of benzoic acid was introduced. One subject was omitted because of incomplete data.
Mentions: Further examination of the possible biosynthesis of SA in man required a labeled precursor study. That showed variability in total serum SA during the study, but in every individual the highest serum SA measured during the 3 days occurred during day 2—at a median time of 4 h (range = 2−8 h) after the first dose of benzoic acid. The areas under the SA level time curves confirmed the highest serum levels were reached on day 2, but that was not significant. The highest level (Figure 2, p = 0.052) of combined SA + SU urinary excretion was observed in the 8−16 h sample after the initial dose of benzoic acid.

Bottom Line: Fasting for major colorectal surgery did not cause disappearance of SA from plasma, even in patients following total proctocolectomy.A (13)C(6) benzoic acid load ingested by six volunteers led, between 8 and 16 h, to a median 33.9% labeling of urinary salicyluric acid.The overall contribution of benzoic acid (and its salts) to the turnover of circulating SA thus requires further assessment.

View Article: PubMed Central - PubMed

Affiliation: Dumfries and Galloway Royal Infirmary, Bankend Road, Dumfries DG1 4AP, United Kingdom.

ABSTRACT
Salicylic acid (SA), which is central to defense mechanisms in plants and the principal metabolite of aspirin, occurs naturally in man with higher levels of SA and its urinary metabolite salicyluric acid (SU) in vegetarians overlapping with levels in patients on low-dose aspirin regimens. SA is widely distributed in animal blood. Fasting for major colorectal surgery did not cause disappearance of SA from plasma, even in patients following total proctocolectomy. A (13)C(6) benzoic acid load ingested by six volunteers led, between 8 and 16 h, to a median 33.9% labeling of urinary salicyluric acid. The overall contribution of benzoic acid (and its salts) to the turnover of circulating SA thus requires further assessment. However, that SA appears to be, at least partially, an endogenous compound should lead to reassessment of its role in human (and animal) pathophysiology.

Show MeSH
Related in: MedlinePlus