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Salicylic acid sans aspirin in animals and man: persistence in fasting and biosynthesis from benzoic acid.

Paterson JR, Baxter G, Dreyer JS, Halket JM, Flynn R, Lawrence JR - J. Agric. Food Chem. (2008)

Bottom Line: Fasting for major colorectal surgery did not cause disappearance of SA from plasma, even in patients following total proctocolectomy.A (13)C(6) benzoic acid load ingested by six volunteers led, between 8 and 16 h, to a median 33.9% labeling of urinary salicyluric acid.The overall contribution of benzoic acid (and its salts) to the turnover of circulating SA thus requires further assessment.

View Article: PubMed Central - PubMed

Affiliation: Dumfries and Galloway Royal Infirmary, Bankend Road, Dumfries DG1 4AP, United Kingdom.

ABSTRACT
Salicylic acid (SA), which is central to defense mechanisms in plants and the principal metabolite of aspirin, occurs naturally in man with higher levels of SA and its urinary metabolite salicyluric acid (SU) in vegetarians overlapping with levels in patients on low-dose aspirin regimens. SA is widely distributed in animal blood. Fasting for major colorectal surgery did not cause disappearance of SA from plasma, even in patients following total proctocolectomy. A (13)C(6) benzoic acid load ingested by six volunteers led, between 8 and 16 h, to a median 33.9% labeling of urinary salicyluric acid. The overall contribution of benzoic acid (and its salts) to the turnover of circulating SA thus requires further assessment. However, that SA appears to be, at least partially, an endogenous compound should lead to reassessment of its role in human (and animal) pathophysiology.

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Salicyluric acid in pooled urine sample: (a) partial mass spectrum obtained by gas chromatogrphaphy−mass spectrometry of a trimethylsilylated extract of pooled urine (isotopically labeled peaks are indicated by asterisks at m/z values 199, 212, and 330); (b) partial library mass spectrum of the di-trimethylsilyl derivative of standard salicyluric acid (o-hydroxyhippuric acid). Data were analyzed using the Automated Mass Spectral Deconvolution and Identification System (AMDIS; NIST, Gaithersburg, MD; http://chemdata.nist.gov/mass-sps/amdis).
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fig1: Salicyluric acid in pooled urine sample: (a) partial mass spectrum obtained by gas chromatogrphaphy−mass spectrometry of a trimethylsilylated extract of pooled urine (isotopically labeled peaks are indicated by asterisks at m/z values 199, 212, and 330); (b) partial library mass spectrum of the di-trimethylsilyl derivative of standard salicyluric acid (o-hydroxyhippuric acid). Data were analyzed using the Automated Mass Spectral Deconvolution and Identification System (AMDIS; NIST, Gaithersburg, MD; http://chemdata.nist.gov/mass-sps/amdis).

Mentions: To obtain the mass spectra shown in part in Figure 1, aliquots of all of the second-day 8−16 h urine samples were initially pooled prior to derivatization. Data files were analyzed by the Automated Mass Spectral Deconvolution and Identification System (AMDIS; NIST, Gaithersburg, MD; http://chemdata.nist.gov/mass-spc/amdis/).


Salicylic acid sans aspirin in animals and man: persistence in fasting and biosynthesis from benzoic acid.

Paterson JR, Baxter G, Dreyer JS, Halket JM, Flynn R, Lawrence JR - J. Agric. Food Chem. (2008)

Salicyluric acid in pooled urine sample: (a) partial mass spectrum obtained by gas chromatogrphaphy−mass spectrometry of a trimethylsilylated extract of pooled urine (isotopically labeled peaks are indicated by asterisks at m/z values 199, 212, and 330); (b) partial library mass spectrum of the di-trimethylsilyl derivative of standard salicyluric acid (o-hydroxyhippuric acid). Data were analyzed using the Automated Mass Spectral Deconvolution and Identification System (AMDIS; NIST, Gaithersburg, MD; http://chemdata.nist.gov/mass-sps/amdis).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC2800778&req=5

fig1: Salicyluric acid in pooled urine sample: (a) partial mass spectrum obtained by gas chromatogrphaphy−mass spectrometry of a trimethylsilylated extract of pooled urine (isotopically labeled peaks are indicated by asterisks at m/z values 199, 212, and 330); (b) partial library mass spectrum of the di-trimethylsilyl derivative of standard salicyluric acid (o-hydroxyhippuric acid). Data were analyzed using the Automated Mass Spectral Deconvolution and Identification System (AMDIS; NIST, Gaithersburg, MD; http://chemdata.nist.gov/mass-sps/amdis).
Mentions: To obtain the mass spectra shown in part in Figure 1, aliquots of all of the second-day 8−16 h urine samples were initially pooled prior to derivatization. Data files were analyzed by the Automated Mass Spectral Deconvolution and Identification System (AMDIS; NIST, Gaithersburg, MD; http://chemdata.nist.gov/mass-spc/amdis/).

Bottom Line: Fasting for major colorectal surgery did not cause disappearance of SA from plasma, even in patients following total proctocolectomy.A (13)C(6) benzoic acid load ingested by six volunteers led, between 8 and 16 h, to a median 33.9% labeling of urinary salicyluric acid.The overall contribution of benzoic acid (and its salts) to the turnover of circulating SA thus requires further assessment.

View Article: PubMed Central - PubMed

Affiliation: Dumfries and Galloway Royal Infirmary, Bankend Road, Dumfries DG1 4AP, United Kingdom.

ABSTRACT
Salicylic acid (SA), which is central to defense mechanisms in plants and the principal metabolite of aspirin, occurs naturally in man with higher levels of SA and its urinary metabolite salicyluric acid (SU) in vegetarians overlapping with levels in patients on low-dose aspirin regimens. SA is widely distributed in animal blood. Fasting for major colorectal surgery did not cause disappearance of SA from plasma, even in patients following total proctocolectomy. A (13)C(6) benzoic acid load ingested by six volunteers led, between 8 and 16 h, to a median 33.9% labeling of urinary salicyluric acid. The overall contribution of benzoic acid (and its salts) to the turnover of circulating SA thus requires further assessment. However, that SA appears to be, at least partially, an endogenous compound should lead to reassessment of its role in human (and animal) pathophysiology.

Show MeSH
Related in: MedlinePlus