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The real code of leonardo da vinci.

Ose L - Curr Cardiol Rev (2008)

Bottom Line: This is probably the first case of familial hypercholesterolemia (FH).On the contrary, Akira Endo searched for microbial metabolites that would inhibit HMG-CoA reductase, the rate-limiting enzyme in the synthesis of cholesterol and finally, Michael Brown and Joseph Goldstein published a remarkable series of elegant and insightful papers in the 70s and 80s.They established that the cellular uptake of low-density lipoprotein (LDL) essentially requires the LDL receptor. this was the real Code of Leonardo da Vinci.

View Article: PubMed Central - PubMed

Affiliation: Lipid Clinic, Medical Department, Rikshospitalet HF, NO 0027 Oslo Norway.

ABSTRACT

Unlabelled: Leonardo da Vinci was born in Italy. Among the researchers and scientists, he is favourably known for his remarkable efforts in scientific work. His investigations of atherosclerosis judiciously combine three separate fields of research. In 1506, he finished his masterpiece, painting of Mona Lisa. A careful clinical examination of the famous painting reveals a yellow irregular leather-like spot at the inner end of the left upper eyelid and a soft bumpy well-defined swelling of the dorsum of the right hand beneath the index finger about 3 cm long. This is probably the first case of familial hypercholesterolemia (FH). The FH code of Leonardo da Vinci was given immense consideration by scientists like Carl Muller, who described the xanthomas tuberosum and angina pectoris. On the contrary, Akira Endo searched for microbial metabolites that would inhibit HMG-CoA reductase, the rate-limiting enzyme in the synthesis of cholesterol and finally, Michael Brown and Joseph Goldstein published a remarkable series of elegant and insightful papers in the 70s and 80s. They established that the cellular uptake of low-density lipoprotein (LDL) essentially requires the LDL receptor.

In conclusion: this was the real Code of Leonardo da Vinci.

No MeSH data available.


Related in: MedlinePlus

Madonna Lisa Maria de Gherardini (Mona Lisa) 1479-1516 painted by Leonardo da Vinci in 1503-1506. The painting is in Louvre, Paris.
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Figure 1: Madonna Lisa Maria de Gherardini (Mona Lisa) 1479-1516 painted by Leonardo da Vinci in 1503-1506. The painting is in Louvre, Paris.

Mentions: In 1503, Leonardo started the painting of Madonna Lisa Maria de Gherardini born in Florence in 1479 and died at the age of 37 (Fig.1). He worked on the painting for 4 years. A careful clinical examination of the famous painting reveals a yellow irregular leather-like spot at the inner end of the left upper eyelid (Fig. 2) and a soft bumpy well-defined swelling of the dorsum of the right hand beneath the index finger about 3 cm long (Fig. 3). An infrared detailed photograph published in 1974 reveals that the yellow skin alteration was an integral part of the painting at the time of its initiation [2]. The yellow spot looked somewhat similar to what later came to be known as xanthelasma. These skin lesions are often observed in people suffering from inherited forms of hyperlipidemia.


The real code of leonardo da vinci.

Ose L - Curr Cardiol Rev (2008)

Madonna Lisa Maria de Gherardini (Mona Lisa) 1479-1516 painted by Leonardo da Vinci in 1503-1506. The painting is in Louvre, Paris.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC2774586&req=5

Figure 1: Madonna Lisa Maria de Gherardini (Mona Lisa) 1479-1516 painted by Leonardo da Vinci in 1503-1506. The painting is in Louvre, Paris.
Mentions: In 1503, Leonardo started the painting of Madonna Lisa Maria de Gherardini born in Florence in 1479 and died at the age of 37 (Fig.1). He worked on the painting for 4 years. A careful clinical examination of the famous painting reveals a yellow irregular leather-like spot at the inner end of the left upper eyelid (Fig. 2) and a soft bumpy well-defined swelling of the dorsum of the right hand beneath the index finger about 3 cm long (Fig. 3). An infrared detailed photograph published in 1974 reveals that the yellow skin alteration was an integral part of the painting at the time of its initiation [2]. The yellow spot looked somewhat similar to what later came to be known as xanthelasma. These skin lesions are often observed in people suffering from inherited forms of hyperlipidemia.

Bottom Line: This is probably the first case of familial hypercholesterolemia (FH).On the contrary, Akira Endo searched for microbial metabolites that would inhibit HMG-CoA reductase, the rate-limiting enzyme in the synthesis of cholesterol and finally, Michael Brown and Joseph Goldstein published a remarkable series of elegant and insightful papers in the 70s and 80s.They established that the cellular uptake of low-density lipoprotein (LDL) essentially requires the LDL receptor. this was the real Code of Leonardo da Vinci.

View Article: PubMed Central - PubMed

Affiliation: Lipid Clinic, Medical Department, Rikshospitalet HF, NO 0027 Oslo Norway.

ABSTRACT

Unlabelled: Leonardo da Vinci was born in Italy. Among the researchers and scientists, he is favourably known for his remarkable efforts in scientific work. His investigations of atherosclerosis judiciously combine three separate fields of research. In 1506, he finished his masterpiece, painting of Mona Lisa. A careful clinical examination of the famous painting reveals a yellow irregular leather-like spot at the inner end of the left upper eyelid and a soft bumpy well-defined swelling of the dorsum of the right hand beneath the index finger about 3 cm long. This is probably the first case of familial hypercholesterolemia (FH). The FH code of Leonardo da Vinci was given immense consideration by scientists like Carl Muller, who described the xanthomas tuberosum and angina pectoris. On the contrary, Akira Endo searched for microbial metabolites that would inhibit HMG-CoA reductase, the rate-limiting enzyme in the synthesis of cholesterol and finally, Michael Brown and Joseph Goldstein published a remarkable series of elegant and insightful papers in the 70s and 80s. They established that the cellular uptake of low-density lipoprotein (LDL) essentially requires the LDL receptor.

In conclusion: this was the real Code of Leonardo da Vinci.

No MeSH data available.


Related in: MedlinePlus