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Update on thyroid eye disease and management.

Bothun ED, Scheurer RA, Harrison AR, Lee MS - Clin Ophthalmol (2009)

Bottom Line: Thyroid eye disease is a heterogeneous autoimmune orbital reaction typically manifesting in middle age.The orbital manifestations can lead to severe proptosis, dry eyes, strabismus, and optic neuropathy.In this article, we will discuss this unique condition including the ophthalmic findings and management.

View Article: PubMed Central - PubMed

Affiliation: Departments of Ophthalmology, University of Minnesota, MMC 493, Minneapolis, MN, USA. bothu003@umn.edu

ABSTRACT
Thyroid eye disease is a heterogeneous autoimmune orbital reaction typically manifesting in middle age. The inflammation may parallel or remain isolated from a related inflammatory cascade in the thyroid called Graves' disease. The orbital manifestations can lead to severe proptosis, dry eyes, strabismus, and optic neuropathy. In this article, we will discuss this unique condition including the ophthalmic findings and management.

No MeSH data available.


Related in: MedlinePlus

CT imaging of extraocular muscle enlargement at orbital apex.
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f4-opth-3-543: CT imaging of extraocular muscle enlargement at orbital apex.

Mentions: With severe inflammation, the expansion of soft tissues confined within the bony orbit and swelling of the muscles at the apex of the orbit may compress the optic nerve causing dysthyroid optic neuropathy (Figure 4).17 Although early symptoms include progressive blurring of vision and fading of colors in one or both eyes, visual acuity may be preserved in a minority of patients with optic neuropathy.18 Of note, when optic neuropathy occurs the degree of proptosis often does not correlate. Presumably, this occurs when the enlarged EOM expand to compress the optic nerve instead of producing exophthalmos. Signs of optic neuropathy include decrease in visual acuity, visual field, and color vision along with the development of an afferent pupillary defect. Bilateral, simultaneous optic neuropathy can occur which would eliminate a relative afferent pupillary defect. The optic disc may be normal or edematous. Without detection through serial screenings and subsequent prompt treatment, permanent optic atrophy and visual loss may occur.


Update on thyroid eye disease and management.

Bothun ED, Scheurer RA, Harrison AR, Lee MS - Clin Ophthalmol (2009)

CT imaging of extraocular muscle enlargement at orbital apex.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC2770865&req=5

f4-opth-3-543: CT imaging of extraocular muscle enlargement at orbital apex.
Mentions: With severe inflammation, the expansion of soft tissues confined within the bony orbit and swelling of the muscles at the apex of the orbit may compress the optic nerve causing dysthyroid optic neuropathy (Figure 4).17 Although early symptoms include progressive blurring of vision and fading of colors in one or both eyes, visual acuity may be preserved in a minority of patients with optic neuropathy.18 Of note, when optic neuropathy occurs the degree of proptosis often does not correlate. Presumably, this occurs when the enlarged EOM expand to compress the optic nerve instead of producing exophthalmos. Signs of optic neuropathy include decrease in visual acuity, visual field, and color vision along with the development of an afferent pupillary defect. Bilateral, simultaneous optic neuropathy can occur which would eliminate a relative afferent pupillary defect. The optic disc may be normal or edematous. Without detection through serial screenings and subsequent prompt treatment, permanent optic atrophy and visual loss may occur.

Bottom Line: Thyroid eye disease is a heterogeneous autoimmune orbital reaction typically manifesting in middle age.The orbital manifestations can lead to severe proptosis, dry eyes, strabismus, and optic neuropathy.In this article, we will discuss this unique condition including the ophthalmic findings and management.

View Article: PubMed Central - PubMed

Affiliation: Departments of Ophthalmology, University of Minnesota, MMC 493, Minneapolis, MN, USA. bothu003@umn.edu

ABSTRACT
Thyroid eye disease is a heterogeneous autoimmune orbital reaction typically manifesting in middle age. The inflammation may parallel or remain isolated from a related inflammatory cascade in the thyroid called Graves' disease. The orbital manifestations can lead to severe proptosis, dry eyes, strabismus, and optic neuropathy. In this article, we will discuss this unique condition including the ophthalmic findings and management.

No MeSH data available.


Related in: MedlinePlus