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Changes in muscular lipids in unilateral isolated hypertrophy of gastrocnemius muscle can be revealed by 1H MR spectroscopy.

Brechtel K, Machann J, Pick M, Schaefer JF, Claussen CD, Schick F - Korean J Radiol (2009 Nov-Dec)

Bottom Line: Results were compared to a control group of four healthy volunteers.Total amount of muscular lipids in the hypertrophic GM of the patient was clearly increased compared to the controls (38.7 versus 21.8+/-3.5 a.u.) while intramyocellular lipids of the adjacent SOL were lower compared to the contralateral healthy leg.Muscular lipids are substrates for metabolism and can be assessed non-invasively by (1)H-MRS. (1)H-MRS is considered to be a helpful tool in clinical assessment of muscle metabolism in cases with muscular hypo- or hypertrophy.

View Article: PubMed Central - PubMed

Affiliation: Section on Experimental Radiology, Department of Diagnostic Radiology, University of Tuebingen, Hoppe-Seyler-Strasse 3, 72076 Tuebingen, Germany.

ABSTRACT

Objective: To test whether proton magnetic resonance spectroscopy ((1)H-MRS) reveals changes in the lipid content of the gastrocnemius muscle (GM) and soleus muscle (SOL) of a patient with unilateral isolated hypertrophy of the right GM.

Materials and methods: (1)H-MRS was performed on a 1.5 Tesla (T) whole-body unit. Muscular lipids inside SOL and GM were assessed in both calves of the patient by a STEAM (stimulated echo acquisition mode) localization sequence. Results were compared to a control group of four healthy volunteers.

Results: Total amount of muscular lipids in the hypertrophic GM of the patient was clearly increased compared to the controls (38.7 versus 21.8+/-3.5 a.u.) while intramyocellular lipids of the adjacent SOL were lower compared to the contralateral healthy leg.

Conclusion: Muscular lipids are substrates for metabolism and can be assessed non-invasively by (1)H-MRS. (1)H-MRS is considered to be a helpful tool in clinical assessment of muscle metabolism in cases with muscular hypo- or hypertrophy.

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Related in: MedlinePlus

Comparison of total muscle lipid ratio between gastrocnemius muscle and soleus muscle, for normal controls (white diamonds) and patient (grey hexagons). Mean value of normal controls is indicated as black dot with 95%-intervals as error bars. Total muscle lipid-ratio of patient's right leg (with gastrocnemius muscle hypertrophy) is clearly above normal range. TML = total muscle lipid
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Figure 3: Comparison of total muscle lipid ratio between gastrocnemius muscle and soleus muscle, for normal controls (white diamonds) and patient (grey hexagons). Mean value of normal controls is indicated as black dot with 95%-intervals as error bars. Total muscle lipid-ratio of patient's right leg (with gastrocnemius muscle hypertrophy) is clearly above normal range. TML = total muscle lipid

Mentions: To proof the relation between the muscular lipid content of the agonistic GM and SOL, TML-ratios were calculated (TML-ratio = TMLGM/TMLSOL) for each leg. For the patient's hypertrophic right leg the TML-ratio amounted to 2.1 (versus 1.13 ± 0.16 in the control group) (Fig. 3) (Table 1). TML-ratio of the (unaffected) left leg of the patient was in the middle range of the normal controls (1.24 versus 1.24 ± 0.20) (Fig. 3) (Table 1).


Changes in muscular lipids in unilateral isolated hypertrophy of gastrocnemius muscle can be revealed by 1H MR spectroscopy.

Brechtel K, Machann J, Pick M, Schaefer JF, Claussen CD, Schick F - Korean J Radiol (2009 Nov-Dec)

Comparison of total muscle lipid ratio between gastrocnemius muscle and soleus muscle, for normal controls (white diamonds) and patient (grey hexagons). Mean value of normal controls is indicated as black dot with 95%-intervals as error bars. Total muscle lipid-ratio of patient's right leg (with gastrocnemius muscle hypertrophy) is clearly above normal range. TML = total muscle lipid
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC2770818&req=5

Figure 3: Comparison of total muscle lipid ratio between gastrocnemius muscle and soleus muscle, for normal controls (white diamonds) and patient (grey hexagons). Mean value of normal controls is indicated as black dot with 95%-intervals as error bars. Total muscle lipid-ratio of patient's right leg (with gastrocnemius muscle hypertrophy) is clearly above normal range. TML = total muscle lipid
Mentions: To proof the relation between the muscular lipid content of the agonistic GM and SOL, TML-ratios were calculated (TML-ratio = TMLGM/TMLSOL) for each leg. For the patient's hypertrophic right leg the TML-ratio amounted to 2.1 (versus 1.13 ± 0.16 in the control group) (Fig. 3) (Table 1). TML-ratio of the (unaffected) left leg of the patient was in the middle range of the normal controls (1.24 versus 1.24 ± 0.20) (Fig. 3) (Table 1).

Bottom Line: Results were compared to a control group of four healthy volunteers.Total amount of muscular lipids in the hypertrophic GM of the patient was clearly increased compared to the controls (38.7 versus 21.8+/-3.5 a.u.) while intramyocellular lipids of the adjacent SOL were lower compared to the contralateral healthy leg.Muscular lipids are substrates for metabolism and can be assessed non-invasively by (1)H-MRS. (1)H-MRS is considered to be a helpful tool in clinical assessment of muscle metabolism in cases with muscular hypo- or hypertrophy.

View Article: PubMed Central - PubMed

Affiliation: Section on Experimental Radiology, Department of Diagnostic Radiology, University of Tuebingen, Hoppe-Seyler-Strasse 3, 72076 Tuebingen, Germany.

ABSTRACT

Objective: To test whether proton magnetic resonance spectroscopy ((1)H-MRS) reveals changes in the lipid content of the gastrocnemius muscle (GM) and soleus muscle (SOL) of a patient with unilateral isolated hypertrophy of the right GM.

Materials and methods: (1)H-MRS was performed on a 1.5 Tesla (T) whole-body unit. Muscular lipids inside SOL and GM were assessed in both calves of the patient by a STEAM (stimulated echo acquisition mode) localization sequence. Results were compared to a control group of four healthy volunteers.

Results: Total amount of muscular lipids in the hypertrophic GM of the patient was clearly increased compared to the controls (38.7 versus 21.8+/-3.5 a.u.) while intramyocellular lipids of the adjacent SOL were lower compared to the contralateral healthy leg.

Conclusion: Muscular lipids are substrates for metabolism and can be assessed non-invasively by (1)H-MRS. (1)H-MRS is considered to be a helpful tool in clinical assessment of muscle metabolism in cases with muscular hypo- or hypertrophy.

Show MeSH
Related in: MedlinePlus