Limits...
Typical and atypical manifestations of intrathoracic sarcoidosis.

Park HJ, Jung JI, Chung MH, Song SW, Kim HL, Baik JH, Han DH, Kim KJ, Lee KY - Korean J Radiol (2009 Nov-Dec)

Bottom Line: The findings include symmetric, bilateral hilar and paratracheal lymphadenopathy, with or without concomitant parenchymal abnormalities (multiple small nodules in a peribronchovascular distribution along with irregular thickening of the interstitium).However, in 25% to 30% of cases, the radiological findings are atypical and unfamiliar to most radiologists, which cause difficulty for making a correct diagnosis.We have collected cases with unusual radiological findings associated with pulmonary sarcoidosis (unilateral or asymmetric lymphadenopathy, necrosis or cavitation, large opacity, ground glass opacity, an airway abnormality and pleural involvement) and describe the typical forms of the disorder as well.

View Article: PubMed Central - PubMed

Affiliation: Department of Radiology, St. Vincent's Hospital, The Catholic University of Korea, Kyunggi-do 442-723, Korea.

ABSTRACT
Sarcoidosis is a systemic disorder of unknown cause that is characterized by the presence of noncaseating granulomas. The radiological findings associated with sarcoidosis have been well described. The findings include symmetric, bilateral hilar and paratracheal lymphadenopathy, with or without concomitant parenchymal abnormalities (multiple small nodules in a peribronchovascular distribution along with irregular thickening of the interstitium). However, in 25% to 30% of cases, the radiological findings are atypical and unfamiliar to most radiologists, which cause difficulty for making a correct diagnosis. Many atypical forms of intrathoracic sarcoidosis have been described sporadically. We have collected cases with unusual radiological findings associated with pulmonary sarcoidosis (unilateral or asymmetric lymphadenopathy, necrosis or cavitation, large opacity, ground glass opacity, an airway abnormality and pleural involvement) and describe the typical forms of the disorder as well. The understanding of a wide range of the radiological manifestations of sarcoidosis will be very helpful for making a proper diagnosis.

Show MeSH

Related in: MedlinePlus

Imaging findings for necrosis in sarcoidosis are shown. Axial CT scan with lung window setting shows ill-defined irregular consolidation with two small cavities at subpleural region of right middle lobe.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC2770817&req=5

Figure 10: Imaging findings for necrosis in sarcoidosis are shown. Axial CT scan with lung window setting shows ill-defined irregular consolidation with two small cavities at subpleural region of right middle lobe.

Mentions: Although non-necrotizing granulomas are characteristic of sarcoidosis, necrosis or cavitation occurs in less than 1% of patients; necrosis is thought to be due to either ischemic necrosis within conglomerated areas of sarcoid granulomas or extrusion of ischemic hyaline fibrous tissue (Fig. 10). To diagnose the presence of cavities associated with sarcoidosis, cultures for acid-fast bacilli and fungi should be negative and radiologically similar lesions, such as bullae and bronchiectasis, should be ruled out (5, 9, 10).


Typical and atypical manifestations of intrathoracic sarcoidosis.

Park HJ, Jung JI, Chung MH, Song SW, Kim HL, Baik JH, Han DH, Kim KJ, Lee KY - Korean J Radiol (2009 Nov-Dec)

Imaging findings for necrosis in sarcoidosis are shown. Axial CT scan with lung window setting shows ill-defined irregular consolidation with two small cavities at subpleural region of right middle lobe.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC2770817&req=5

Figure 10: Imaging findings for necrosis in sarcoidosis are shown. Axial CT scan with lung window setting shows ill-defined irregular consolidation with two small cavities at subpleural region of right middle lobe.
Mentions: Although non-necrotizing granulomas are characteristic of sarcoidosis, necrosis or cavitation occurs in less than 1% of patients; necrosis is thought to be due to either ischemic necrosis within conglomerated areas of sarcoid granulomas or extrusion of ischemic hyaline fibrous tissue (Fig. 10). To diagnose the presence of cavities associated with sarcoidosis, cultures for acid-fast bacilli and fungi should be negative and radiologically similar lesions, such as bullae and bronchiectasis, should be ruled out (5, 9, 10).

Bottom Line: The findings include symmetric, bilateral hilar and paratracheal lymphadenopathy, with or without concomitant parenchymal abnormalities (multiple small nodules in a peribronchovascular distribution along with irregular thickening of the interstitium).However, in 25% to 30% of cases, the radiological findings are atypical and unfamiliar to most radiologists, which cause difficulty for making a correct diagnosis.We have collected cases with unusual radiological findings associated with pulmonary sarcoidosis (unilateral or asymmetric lymphadenopathy, necrosis or cavitation, large opacity, ground glass opacity, an airway abnormality and pleural involvement) and describe the typical forms of the disorder as well.

View Article: PubMed Central - PubMed

Affiliation: Department of Radiology, St. Vincent's Hospital, The Catholic University of Korea, Kyunggi-do 442-723, Korea.

ABSTRACT
Sarcoidosis is a systemic disorder of unknown cause that is characterized by the presence of noncaseating granulomas. The radiological findings associated with sarcoidosis have been well described. The findings include symmetric, bilateral hilar and paratracheal lymphadenopathy, with or without concomitant parenchymal abnormalities (multiple small nodules in a peribronchovascular distribution along with irregular thickening of the interstitium). However, in 25% to 30% of cases, the radiological findings are atypical and unfamiliar to most radiologists, which cause difficulty for making a correct diagnosis. Many atypical forms of intrathoracic sarcoidosis have been described sporadically. We have collected cases with unusual radiological findings associated with pulmonary sarcoidosis (unilateral or asymmetric lymphadenopathy, necrosis or cavitation, large opacity, ground glass opacity, an airway abnormality and pleural involvement) and describe the typical forms of the disorder as well. The understanding of a wide range of the radiological manifestations of sarcoidosis will be very helpful for making a proper diagnosis.

Show MeSH
Related in: MedlinePlus