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Poly(hydroxyalkanoates)-based polymeric nanoparticles for drug delivery.

Errico C, Bartoli C, Chiellini F, Chiellini E - J. Biomed. Biotechnol. (2009)

Bottom Line: The relevant results obtained give a theoretical understanding of the phenomenon occurring during colloidal formation.The adopted procedure allows for a relatively small diameter and homogeneity in size distribution of the PHB nanoparticles to be obtained compared to other methods like the one based on solvent evaporation which leads to particles on microscale.The biocompatibility of PHB and relative nanoparticles was investigated and both exhibited very good cytocompatibility.

View Article: PubMed Central - PubMed

Affiliation: Laboratory of Bioactive Polymeric Materials for Biomedical & Environmental Applications, UdR-INSTM, Department of Chemistry and Industrial Chemistry, University of Pisa, Via Risorgimento 35, 56126 Pisa, Italy.

ABSTRACT
Poly (hydroxyalkanoates) (PHAs) have recently attracted a great deal of academic and industrial interest for their biodegradability and biocompatibility making them suitable for environmental and biomedical applications. Poly(3-hydroxybutyrate-) (PHB-) and Poly(DL-lactide-co-glycolide) (PLGA-) based nanoparticles were prepared using the dialysis method as yet unreported for the preparation of nanoparticles based on PHB. Processing conditions were varied in order to evaluate their influence on morphology, drug encapsulation, and size of nanoparticles. The relevant results obtained give a theoretical understanding of the phenomenon occurring during colloidal formation. The adopted procedure allows for a relatively small diameter and homogeneity in size distribution of the PHB nanoparticles to be obtained compared to other methods like the one based on solvent evaporation which leads to particles on microscale. The biocompatibility of PHB and relative nanoparticles was investigated and both exhibited very good cytocompatibility.

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SEM image and particle size distribution of LG-10 NPs.
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Related In: Results  -  Collection


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fig5: SEM image and particle size distribution of LG-10 NPs.

Mentions: In order to reduce the formation of flakes and to increase the loading efficiency, a surfactant (Pluronic F-127) was added to the formulation. Pluronic: due to its amphiphilic character, could mediate the interaction between the polymer and the drug avoiding the formation of flakes and precipitates. The presence of the surfactant influenced the average diameter size of the nanoparticles but had only a slight effect on the formation of flakes which was only partially reduced. Particle size increased resulting in the range of 500–700 nm (Figure 5).


Poly(hydroxyalkanoates)-based polymeric nanoparticles for drug delivery.

Errico C, Bartoli C, Chiellini F, Chiellini E - J. Biomed. Biotechnol. (2009)

SEM image and particle size distribution of LG-10 NPs.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC2749206&req=5

fig5: SEM image and particle size distribution of LG-10 NPs.
Mentions: In order to reduce the formation of flakes and to increase the loading efficiency, a surfactant (Pluronic F-127) was added to the formulation. Pluronic: due to its amphiphilic character, could mediate the interaction between the polymer and the drug avoiding the formation of flakes and precipitates. The presence of the surfactant influenced the average diameter size of the nanoparticles but had only a slight effect on the formation of flakes which was only partially reduced. Particle size increased resulting in the range of 500–700 nm (Figure 5).

Bottom Line: The relevant results obtained give a theoretical understanding of the phenomenon occurring during colloidal formation.The adopted procedure allows for a relatively small diameter and homogeneity in size distribution of the PHB nanoparticles to be obtained compared to other methods like the one based on solvent evaporation which leads to particles on microscale.The biocompatibility of PHB and relative nanoparticles was investigated and both exhibited very good cytocompatibility.

View Article: PubMed Central - PubMed

Affiliation: Laboratory of Bioactive Polymeric Materials for Biomedical & Environmental Applications, UdR-INSTM, Department of Chemistry and Industrial Chemistry, University of Pisa, Via Risorgimento 35, 56126 Pisa, Italy.

ABSTRACT
Poly (hydroxyalkanoates) (PHAs) have recently attracted a great deal of academic and industrial interest for their biodegradability and biocompatibility making them suitable for environmental and biomedical applications. Poly(3-hydroxybutyrate-) (PHB-) and Poly(DL-lactide-co-glycolide) (PLGA-) based nanoparticles were prepared using the dialysis method as yet unreported for the preparation of nanoparticles based on PHB. Processing conditions were varied in order to evaluate their influence on morphology, drug encapsulation, and size of nanoparticles. The relevant results obtained give a theoretical understanding of the phenomenon occurring during colloidal formation. The adopted procedure allows for a relatively small diameter and homogeneity in size distribution of the PHB nanoparticles to be obtained compared to other methods like the one based on solvent evaporation which leads to particles on microscale. The biocompatibility of PHB and relative nanoparticles was investigated and both exhibited very good cytocompatibility.

Show MeSH